CAJ | 학술논문

目的探讨前葡萄膜炎的病因、类型、临床特点及预后.方法回顾性病例研究.分析2006年12月至2012年7月就诊于我院葡萄膜炎专科的650例前葡萄膜炎患者(856眼)的临床资料,根据病史、临床表现、合并全身性疾病、辅助检查及实验室检查等,对前葡萄膜炎的病因、临床特点、治疗效果及预后进行探讨.结果 650例前葡萄膜炎患者(856眼)中单眼发病444例,双眼发病206例,男394例,女256例,男女比例为1.5∶1;平均发病年龄(39.0±15.0)岁,20～50岁之间的青壮年患者占总病例的71.4％.急性期689眼,慢性期167眼.按病因主要分为特发性前葡萄膜炎(243例,37.4％),不伴发全身关节病变的HLA-B27相关性前葡萄膜炎(123例,18.9％),强直性脊柱炎(105例,16.2％),Fuchs综合征(74例,11.4％)和病毒感染(44例,6.8％).各种并发症发生率为39.5％,主要为并发性白内障(41.1％)和继发性青光眼(35.1％).治疗后视力≥0.5者占75.4％,0.05～者占20.3％,＜0.05者占4.3％.结论前葡萄膜炎发病率高,病因复杂多样,易复发,如治疗不当将产生严重并发症.因此应对前葡萄膜炎患者进行详细、系统的检查,积极查因,从而指导临床治疗及预后.
목적 탐토전포도막염적병인、류형、림상특점급예후.방법 회고성병례연구.분석2006년12월지2012년7월취진우아원포도막염전과적650례전포도막염환자(856안)적림상자료,근거병사、림상표현、합병전신성질병、보조검사급실험실검사등,대전포도막염적병인、림상특점、치료효과급예후진행탐토.결과 650례전포도막염환자(856안)중단안발병444례,쌍안발병206례,남394례,녀256례,남녀비례위1.5∶1;평균발병년령(39.0±15.0)세,20～50세지간적청장년환자점총병례적71.4％.급성기689안,만성기167안.안병인주요분위특발성전포도막염(243례,37.4％),불반발전신관절병변적HLA-B27상관성전포도막염(123례,18.9％),강직성척주염(105례,16.2％),Fuchs종합정(74례,11.4％)화병독감염(44례,6.8％).각충병발증발생솔위39.5％,주요위병발성백내장(41.1％)화계발성청광안(35.1％).치료후시력≥0.5자점75.4％,0.05～자점20.3％,＜0.05자점4.3％.결론 전포도막염발병솔고,병인복잡다양,역복발,여치료불당장산생엄중병발증.인차응대전포도막염환자진행상세、계통적검사,적겁사인,종이지도림상치료급예후.
Objective To investigate the prevalence of anterior uveitis and to assess the etiology,classification,clinical features,treatment outcomes and prognosis of uveitis.Methods Six hundred fifty patients (206 patients were bilateral) with anterior uveitis referred to the Eye Hospital of Wenzhou Medical University during the period of December 2006 to July 2012 were retrospectively analyzed.The etiology,clinical characteristics,treatment outcomes and prognosis based on the case history,clinical manifestation,systemic diseases,auxiliary examination and laboratory examination were assessed.Results The average age at disease onset (394 males and 256 females) was 39.0±15.0 years.There were 689 eyes with acute anterior uveitis and 167 eyes with chronic anterior uveitis.The most common type was idiopathic uveitis (243 cases,37.4％),and it was followed in descending order by HLA-B27 associated uveitis that was not accompanied by systemic arthritic disease (123 cases,18.9％),ankylosing spondylitis (105 cases,16.2％),Fuchs syndrome (74 cases,11.4％) and virus infection (44 cases,6.8％).The rate of complications was 39.5％.The rate of mild visual impairment (0.05～) was 20.3％ and the rate of blindness (less than 0.05) was 4.3％.Conclusion Anterior uveitis was a disease with variable etiologies that usually occurred in young and middle-aged adults.The development of uveitis can be either bilateral or unilateral and can lead to severe complications.Careful and systemic examinations to actively identify the etiology are necessary for these patients.