CAJ | 학술논문

“真实世界”研究(RWS)是起源于实用性的临床试验,属于药物流行病学的范畴.是基于临床真实的干预情况采取的一种非随机、开放性、不使用安慰剂的研究,因此其得出的结果具有很高的外部有效性.目前RWS已得到很多医学领域的重视,有些学科已经建立了较为完整的观察性队列、登记和管理型数据库.眼科学界对RWS设计的尝试才刚刚起步.笔者就RWS的背景、概念、方法以及在眼科的应用做一文献复习.
“진실세계”연구(RWS)시기원우실용성적림상시험,속우약물류행병학적범주.시기우림상진실적간예정황채취적일충비수궤、개방성、불사용안위제적연구,인차기득출적결과구유흔고적외부유효성.목전RWS이득도흔다의학영역적중시,유사학과이경건립료교위완정적관찰성대렬、등기화관리형수거고.안과학계대RWS설계적상시재강강기보.필자취RWS적배경、개념、방법이급재안과적응용주일문헌복습.
Real-World Study (RWS) is originated in the practical clinical trials,which belongs to the category of drug epidemiology.It is non-random,open,no placebo research,and based on the clinical actual situation and the emphasizing the external validity of the research results.The RWS has received a lot of attention and in some field of medicine,disease-specific observational cohort,registry and management database have been well-established.While the RWS in ophthalmology is just starting up.In this article,the background,concepts,methods of RWS and its application in ophthalmology were reviewed.