CAJ | 학술논문

目的探讨中国青年女性生理周期期间角膜生物力学性能和眼压的节律性变化以及两者之间的关系.方法前瞻性研究.41例健康青年女性分别在月经周期初期、排卵期和月经周期末期用眼反应分析仪(ORA)对角膜补偿眼压(IOPcc)、可重复模拟Goldmman眼压(IOPg)、角膜滞后量(CH)和角膜阻力因子(CRF)进行测量.采用Pentacam对CCT进行测量.采用重复测量方差分析法分析测量参数在不同时间点的变化以及Pearson相关进行相关性分析.结果在女性生理周期的不同阶段,CCT、CH和CRF存在波动,但差异无统计学意义,在月经周期末期IOPcc和IOPg均较初期显著下降(P＜0.01).△IOPg与△CRF呈低度正相关(r=0.356,P＜0.05),与△CH呈低度负相关(r=-0.336,P＜0.05),△IOPcc则与△CH呈中度负相关(r=-0.702,P＜0.01),与△CRF不相关(r=-0.069,P＞0.05).△CRF、△CH、△IOPg和△IOPcc均与△CCT无明显相关性(|r|均＜0.3,P均＞0.05).结论在女性生理周期期间,角膜生物力学性能无明显变化但眼压在月经周期末期发生了显著下降.IOPg的变化与CH 、CRF低度相关,而IOPcc则与CH中度相关,与CRF不相关.角膜生物力学性能可能是眼压的影响因素之一.
목적 탐토중국청년녀성생리주기기간각막생물역학성능화안압적절률성변화이급량자지간적관계.방법 전첨성연구.41례건강청년녀성분별재월경주기초기、배란기화월경주기말기용안반응분석의(ORA)대각막보상안압(IOPcc)、가중복모의Goldmman안압(IOPg)、각막체후량(CH)화각막조력인자(CRF)진행측량.채용Pentacam대CCT진행측량.채용중복측량방차분석법분석측량삼수재불동시간점적변화이급Pearson상관진행상관성분석.결과 재녀성생리주기적불동계단,CCT、CH화CRF존재파동,단차이무통계학의의,재월경주기말기IOPcc화IOPg균교초기현저하강(P＜0.01).△IOPg여△CRF정저도정상관(r=0.356,P＜0.05),여△CH정저도부상관(r=-0.336,P＜0.05),△IOPcc칙여△CH정중도부상관(r=-0.702,P＜0.01),여△CRF불상관(r=-0.069,P＞0.05).△CRF、△CH、△IOPg화△IOPcc균여△CCT무명현상관성(|r|균＜0.3,P균＞0.05).결론 재녀성생리주기기간,각막생물역학성능무명현변화단안압재월경주기말기발생료현저하강.IOPg적변화여CH 、CRF저도상관,이IOPcc칙여CH중도상관,여CRF불상관.각막생물역학성능가능시안압적영향인소지일.
Objective To determine the variations in corneal biomechanical parameters and intraocular pressure (IOP) during female menstrual cycle and to examine the relationship between them.Methods Forty-one young healthy Chinese women were prospectively recruited.Corneal hysteresis (CH),corneal resistance factor (CRF),Goldman-correlated intraocular pressure (IOPg) and corneal-compensated intraocular pressure (IOPcc) were measured with Ocular Response Analyzer at three phases of menstrual cycle (at the beginning,at ovulation and at the end of the cycle).Central corneal thickness (CCT) was measured with Oculus Pentacam.Repeated measured ANOVA and Pearson correlation coefficients were used for statistical analysis.Results IOPg and IOPcc were significantly decreased at the end compared with at the beginning (P＜0.01).CCT,CH and CRF were stable during the menstrual cycle.Compared at the beginning with at the end,the change of IOPg was positively correlated with the change of CRF (r=0.356,P＜0.05),but negatively correlated with the change of CH (r=-0.336,P＜0.05).The change of IOPcc was negatively correlated with the change of CH (r=-0.702,P＜0.01),but had no relation with the change of CRF (r=-0.069,P＞0.05).The change of CRF,CH,IOPg and IOPcc had no relation with the change of CCT (| r | ＜0.3,P＞0.05for all parameters).Conclusion During the menstrual cycle,CH and CRF kept stable but IOPcc and IOPg were significantly reduced at the end.The change of IOPg was correlated with the change of CH and CRF,and the change of IOPcc was only correlated with the change of CH.