中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
30期
11-13
,共3页
昂丹司琼%格拉司琼%手术后恶心呕吐
昂丹司瓊%格拉司瓊%手術後噁心嘔吐
앙단사경%격랍사경%수술후악심구토
Ondansetron%Granisetron%Postoperative nausea and vomiting
目的 探讨预防心脏手术后恶心呕吐(PONV)的方法,对比研究昂丹司琼和格拉司琼对心脏PONV的影响.方法 选择气管内插管全身麻醉下行心脏手术的患者90例,随机分成三组,每组各30例.以双盲方式按下述方法给药:Ⅰ组麻醉诱导前静脉注射昂丹司琼4 mg(溶于0.9%NaCl溶液加ml);Ⅱ组麻醉诱导前静脉注射格拉司琼3 mg(溶于0.9%NaCl溶液20 ml);Ⅲ组麻醉诱导前静脉注射0.9%NaCl溶液20 ml.术后12、24 h观察记录患者的PONV程度并进行比较.结果 Ⅰ组术后12 h PONV发生率为20.0%(6/30),术后24 h发生率为26.7%(8/30);Ⅱ组术后12 hPONV发生率为20.0%(6/30),术后24 h发生率为23.3%(7/30);Ⅲ组术后12 h PONV发生率为72.4%(21/29),术后24 h发生率为79.3%(23/29).Ⅰ、Ⅱ组术后12、24 hPONV发生率显著低于Ⅲ组(P＜0.01),Ⅰ组和Ⅱ组比较差异无统计学意义(P＞0.05).结论 昂丹司琼和格拉司琼对预防心脏PONV均有较好效果,均能有效地降低心脏PONV的发生率,利于患者恢复.
目的 探討預防心髒手術後噁心嘔吐(PONV)的方法,對比研究昂丹司瓊和格拉司瓊對心髒PONV的影響.方法 選擇氣管內插管全身痳醉下行心髒手術的患者90例,隨機分成三組,每組各30例.以雙盲方式按下述方法給藥:Ⅰ組痳醉誘導前靜脈註射昂丹司瓊4 mg(溶于0.9%NaCl溶液加ml);Ⅱ組痳醉誘導前靜脈註射格拉司瓊3 mg(溶于0.9%NaCl溶液20 ml);Ⅲ組痳醉誘導前靜脈註射0.9%NaCl溶液20 ml.術後12、24 h觀察記錄患者的PONV程度併進行比較.結果 Ⅰ組術後12 h PONV髮生率為20.0%(6/30),術後24 h髮生率為26.7%(8/30);Ⅱ組術後12 hPONV髮生率為20.0%(6/30),術後24 h髮生率為23.3%(7/30);Ⅲ組術後12 h PONV髮生率為72.4%(21/29),術後24 h髮生率為79.3%(23/29).Ⅰ、Ⅱ組術後12、24 hPONV髮生率顯著低于Ⅲ組(P＜0.01),Ⅰ組和Ⅱ組比較差異無統計學意義(P＞0.05).結論 昂丹司瓊和格拉司瓊對預防心髒PONV均有較好效果,均能有效地降低心髒PONV的髮生率,利于患者恢複.
목적 탐토예방심장수술후악심구토(PONV)적방법,대비연구앙단사경화격랍사경대심장PONV적영향.방법 선택기관내삽관전신마취하행심장수술적환자90례,수궤분성삼조,매조각30례.이쌍맹방식안하술방법급약:Ⅰ조마취유도전정맥주사앙단사경4 mg(용우0.9%NaCl용액가ml);Ⅱ조마취유도전정맥주사격랍사경3 mg(용우0.9%NaCl용액20 ml);Ⅲ조마취유도전정맥주사0.9%NaCl용액20 ml.술후12、24 h관찰기록환자적PONV정도병진행비교.결과 Ⅰ조술후12 h PONV발생솔위20.0%(6/30),술후24 h발생솔위26.7%(8/30);Ⅱ조술후12 hPONV발생솔위20.0%(6/30),술후24 h발생솔위23.3%(7/30);Ⅲ조술후12 h PONV발생솔위72.4%(21/29),술후24 h발생솔위79.3%(23/29).Ⅰ、Ⅱ조술후12、24 hPONV발생솔현저저우Ⅲ조(P＜0.01),Ⅰ조화Ⅱ조비교차이무통계학의의(P＞0.05).결론 앙단사경화격랍사경대예방심장PONV균유교호효과,균능유효지강저심장PONV적발생솔,리우환자회복.
Objective To compare the effect of ondansetron and granisetron on preventing postoperative nausea and vomiting (PONV) after cardiac surgery. Methods Ninety patients (30 cases in each of three groups) who underwent cardiac surgery under general anesthesia with endotracheal intubation were enrolled in this randomized and double-blinded study. Group I received ondansetron 4 mg (in normal saline 20 ml)at the beginning of anesthesia. Group II received granisetron 3 mg (in normal saline 20 ml) at the beginning of anesthesia. Group III received normal saline 20 ml at the beginning of anesthesia. PONV episodes were recorded at 12 and 24 hours after surgery. Results The incidences of PONV at 12 and 24 hours after surgery in group I[20.0%(6/30),26.7%(8/30)]and group II[20.0%(6/30),23.3%(7/30)]were significantly lower than those in group III[72.4%(21/29),79.3%(23/29)](P＜0.01). No significant differences were observed in the terms of complete inhibition rate of PONV between group I and group II (P＞0.05). ConclusionsBoth ondansetron and granisetron have significant effect on reducing the incidence of PONV after cardiac surgery. Intravenous ondansetron (4 mg) or granisetron (3 mg) before anesthesia induction can prevent PONV with similar efficacy and safety.
