CAJ | 학술논문

目的利用局部一致性(ReHo)指标观察短暂性脑缺血发作间期静息态脑功能特点.方法分别对16例短暂性脑缺血发作间期患者(短暂性脑缺血发作间期组)和16例健康体检者(对照组)行静息态功能磁共振成像(fMRI)扫描,使用DPARSF软件分析两组ReHo的变化.结果与对照组比较,短暂性脑缺血发作间期组ReHo降低区域包括左侧扣带回(z=-3.72)、左侧额前回(z=-3.02)、右侧额前回(z=-3.23)、右侧额上回(z=-3.75)、右侧楔前叶(z=-3.80)、右侧顶下小叶(z=-3.98)、左侧顶下小叶(z=-3.82)、中央前回(z=-3.85)、右侧额中回(z=-4.15)、右侧颞中回(z=-3.43),ReHo增高区域包括右侧海马(z=3.37)及右侧小脑(z=3.55).结论短暂性脑缺血发作间期患者静息态脑功能存在异常,海马和小脑的ReHo升高可能反映了脑对短暂性脑缺血发作应激性保护和大脑局部脑功能代偿性反应.
목적 이용국부일치성(ReHo)지표관찰단잠성뇌결혈발작간기정식태뇌공능특점.방법 분별대16례단잠성뇌결혈발작간기환자(단잠성뇌결혈발작간기조)화16례건강체검자(대조조)행정식태공능자공진성상(fMRI)소묘,사용DPARSF연건분석량조ReHo적변화.결과 여대조조비교,단잠성뇌결혈발작간기조ReHo강저구역포괄좌측구대회(z=-3.72)、좌측액전회(z=-3.02)、우측액전회(z=-3.23)、우측액상회(z=-3.75)、우측설전협(z=-3.80)、우측정하소협(z=-3.98)、좌측정하소협(z=-3.82)、중앙전회(z=-3.85)、우측액중회(z=-4.15)、우측섭중회(z=-3.43),ReHo증고구역포괄우측해마(z=3.37)급우측소뇌(z=3.55).결론 단잠성뇌결혈발작간기환자정식태뇌공능존재이상,해마화소뇌적ReHo승고가능반영료뇌대단잠성뇌결혈발작응격성보호화대뇌국부뇌공능대상성반응.
Objective To investigate the brain function in the patients with transient ischemic attack (TIA) using index of regional homogeneity ( ReHo ).Methods Sixteen TIA patients ( TIA group ) and 16 age-matched normal controls (control group) underwent standard resting state functional MRI (fMRI)scan.The changes of the brain ReHo were studied by DPARSF analysis.Results Compared with that of control group,TIA group showed significantly decreased ReHo in the left cingulate gyrus (z =-3.72),left frontal gyrus (z =-3.02),right frontal gyrus (z =-3.23),right superior frontal gyrus (z =-3.75),right precuneus (z =-3.80),right inferior parietal lobule (z =-3.98 ),left inferior parietal lobule (z =-3.82),precentral gyrus ( z =- 3.85 ),right midfrontal gyrus ( z =-4.15 ),right midtemporal gyrus (z =- 3.43 ),and increased ReHo in the right hippocampus (z =3.37) and right cerebellum (z =3.55).Conclusion The rest-state brain function is abnormal in TIA interictal phase,and the increased ReHo in the hippocampus and cerebellum may reflect stress-induced brain protection of TIA and partial comoensatory response.