CAJ | 학술논문

目的探讨血浆血栓调节蛋白(TM)、血管性血友病因子(vWF)水平变化与急性缺血性结肠炎的病变范围及病情轻重的关系.方法采用酶联免疫吸附法分别测定46例急性缺血性结肠炎患者(急性缺血性结肠炎组)、42例溃疡性结肠炎患者(溃疡性结肠炎组)、40例健康体检者(对照组)血浆TM、vWF水平.结果急性缺血性结肠炎组血浆TM (49.6±2.3) μg/L、vWF(198.8±8.9)％；溃疡性结肠炎组血浆TM(38.2±3.8) μg/L、vWF( 162.6±7.6)％；对照组血浆TM(23.8±2.3) μg/L、vWF( 116.7±6.2)％；急性缺血性结肠炎组血浆TM、vWF水平显著高于溃疡性结肠炎组及对照组,差异有统计学意义(P＜0.05或＜0.01)；溃疡性结肠炎组血浆TM、vWF水平显著高于对照组,差异有统计学意义(P＜0.05).急性缺血性结肠炎组全结肠病变患者血浆TM、vWF水平[(49.9±0.3) μg/L、(210.6±8.2)％]显著高于其他病变部位患者,差异有统计学意义(P＜0.05).结论急性缺血性结肠炎患者均存在不同程度的凝血和纤溶系统的激活,联合检测血浆TM、vWF水平可作为急性缺血性结肠炎病情进展、预后判定的指标之一.
목적 탐토혈장혈전조절단백(TM)、혈관성혈우병인자(vWF)수평변화여급성결혈성결장염적병변범위급병정경중적관계.방법 채용매련면역흡부법분별측정46례급성결혈성결장염환자(급성결혈성결장염조)、42례궤양성결장염환자(궤양성결장염조)、40례건강체검자(대조조)혈장TM、vWF수평.결과 급성결혈성결장염조혈장TM (49.6±2.3) μg/L、vWF(198.8±8.9)％；궤양성결장염조혈장TM(38.2±3.8) μg/L、vWF( 162.6±7.6)％；대조조혈장TM(23.8±2.3) μg/L、vWF( 116.7±6.2)％；급성결혈성결장염조혈장TM、vWF수평현저고우궤양성결장염조급대조조,차이유통계학의의(P＜0.05혹＜0.01)；궤양성결장염조혈장TM、vWF수평현저고우대조조,차이유통계학의의(P＜0.05).급성결혈성결장염조전결장병변환자혈장TM、vWF수평[(49.9±0.3) μg/L、(210.6±8.2)％]현저고우기타병변부위환자,차이유통계학의의(P＜0.05).결론 급성결혈성결장염환자균존재불동정도적응혈화섬용계통적격활,연합검측혈장TM、vWF수평가작위급성결혈성결장염병정진전、예후판정적지표지일.
Objective To study the changes of the plasma thrombomodulin (TM) and von Willebrand factor (vWF) levels and their clinical significance associated with the extent and severity of acute ischemie colitis.Methods The plasma TM and vWF levels were determined by enzyme linked immunosorbent assay in 46 patients with acute ischemic colitis (acute ischemic colitis group),42 patients with ulcerative colitis (ulcerative colitis group) and 40 healthy subjects (control group).Results The plasma TM was (49.6 ±2.3) μg/L,and vWF was (198.8 ±8.9)％ in acute ischemic colitis group.The plasma TM was (38.2 ± 3.8) μ g/L,and vWF was ( 162.6 ± 7.6)％ in ulcerative colitis group.The plasma TM was (23.8 ±2.3) μg/L,and vWF was ( 116.7 ± 6.2)％ in control group.The plasma TM and vWF levels in acute ischemic colitis group were higher than those in ulcerative colitis group and control group (P ＜ 0.05 or ＜ 0.01 ).The plasma TM and vWF levels in ulcerative colitis group were higher than those in control group (P＜ 0.05).The plasma TM levels [(49.9 ± 0.3 ) μg/L] and vWF [(210.6 ± 8.2 ) ％] in all colon disease were higher than those in partial colon disease (P ＜ 0.05 ).Conclusion The changes of plasma TM and vWF levels can be used as one of the indicators for assessment of the development and the prognosis of acute ischemic colitis.