CAJ | 학술논문

目的研究感染相关性反应性血小板增多的发病机制.方法选择75例感染性疾病患者,其中感染急性期血小板增高组42例,感染急性期血小板正常组18例,感染恢复期组15例；16例健康体检者(对照组).检测比较各组血清血小板生成素(TPO)、白细胞介素-6(IL-6)及血白细胞、血小板水平,感染性疾病患者进行各指标相关性分析.结果感染急性期血小板增高组血清TPO水平(159.1±65.9) ng/L,高于感染急性期血小板正常组、感染恢复期组、对照组[(43.5±14.4)、(40.3±15.2)、(41.8±18.9) ng/L],差异有统计学意义(P＜0.05),血清IL-6水平在感染急性期血小板增高组[(542.7±247.0) ng/L]与感染急性期血小板正常组[(598.5±250.4) ng/L]之间比较差异无统计学意义(P＞0.05),但感染急性期血小板增高组和感染急性期血小板正常组血清IL-6水平分别高于感染恢复期组[(43.5±20.7) ng/L]和对照组[(38.3±17.6) ng/L],差异有统计学意义(P＜0.05).75例感染性疾病患者中,血清IL-6、TPO与血小板、白细胞呈正相关,血清TPO与IL-6呈正相关.结论 TPO升高促进巨核细胞增殖、生成及释放血小板增加可能是感染相关性反应性血小板增多的发病机制.
목적 연구감염상관성반응성혈소판증다적발병궤제.방법 선택75례감염성질병환자,기중감염급성기혈소판증고조42례,감염급성기혈소판정상조18례,감염회복기조15례；16례건강체검자(대조조).검측비교각조혈청혈소판생성소(TPO)、백세포개소-6(IL-6)급혈백세포、혈소판수평,감염성질병환자진행각지표상관성분석.결과 감염급성기혈소판증고조혈청TPO수평(159.1±65.9) ng/L,고우감염급성기혈소판정상조、감염회복기조、대조조[(43.5±14.4)、(40.3±15.2)、(41.8±18.9) ng/L],차이유통계학의의(P＜0.05),혈청IL-6수평재감염급성기혈소판증고조[(542.7±247.0) ng/L]여감염급성기혈소판정상조[(598.5±250.4) ng/L]지간비교차이무통계학의의(P＞0.05),단감염급성기혈소판증고조화감염급성기혈소판정상조혈청IL-6수평분별고우감염회복기조[(43.5±20.7) ng/L]화대조조[(38.3±17.6) ng/L],차이유통계학의의(P＜0.05).75례감염성질병환자중,혈청IL-6、TPO여혈소판、백세포정정상관,혈청TPO여IL-6정정상관.결론 TPO승고촉진거핵세포증식、생성급석방혈소판증가가능시감염상관성반응성혈소판증다적발병궤제.
Objective To study the mechanism of infection-related reactive thrombocytosis.Methods Seventy-five infectious disease patients were selected including 42 cases with acute infections phase thrombocytosis (acute infectious phase thrombocytosis group),18 cases with acute infectious phase normal platelet count (acute infectious phase normal platelet count group),15 cases with recovered phase (infectious recovered phase group) and 16 cases with healthy controls (control group).The serum thrombopoietin (TPO),intefleukin-6 (IL-6),white blood cell,platelet was determined and compared among 4 groups.Results The serum TPO in acute infectious phase thrombocytosis group [( 159.1 ± 65.9) ng/L]was higher than that in acute infectious phase normal platelet count group,infectious recovered phase group,and control group [(43.5 ± 14.4),(40.3 ± 15.2),(41.8 ± 18.9) ng/L](P＜ 0.05).There was no significant difference in the serum IL-6 between acute infectious phase thrombocytosis group [(542.7 ± 247.0) ng/L]and acute infectious phase normal platelet count group [(598.5 ± 250.4) ng/L] (P ＞ 0.05 ),but which was higher than that in infectious recovered phase group [(43.5 ± 20.7 ) ng/L] and control group [( 38.3 ± 17.6 )ng/L] respectively (P ＜ 0.05 ).The serum IL-6,TPO was positively correlated with platelet,white blood cell.The serum TPO was positively correlated with IL-6.Conclusion Elevated TPO leads to the thrombocytosis,which is the possible mechanism of infection-related reactive thrombocytosis.