中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
25期
27-29
,共3页
孙桂珍%金北平%张小红%张海燕%刘志胜
孫桂珍%金北平%張小紅%張海燕%劉誌勝
손계진%금북평%장소홍%장해연%류지성
白细胞介素11%环孢菌素类%紫癜,血小板减少性,特发性
白細胞介素11%環孢菌素類%紫癜,血小闆減少性,特髮性
백세포개소11%배포균소류%자전,혈소판감소성,특발성
Interleukin-11%Cyclosporins%Purpura,thrombocytopenic,idiopathic
目的 观察重组人白细胞介素-11联合环孢素治疗糖皮质激素无效的原发免疫性血小板减少症的临床疗效.方法 选取2009年8月至2011年8月糖皮质激素治疗无效的原发免疫性血小板减少症患者35例,根据治疗方案分为两组,对照组13例采用环孢素治疗,观察组22例在环孢素治疗基础上联合重组人白细胞介素-11治疗.对比观察两组治疗后的临床疗效及血小板计数变化情况.结果 观察组的总有效率为90.9％ (20/22),明显高于对照组的53.8％(7/13),差异有统计学意义(P＜ 0.05).治疗后对照组和观察组血小板计数均较治疗前明显升高[(112.5±15.4)×109/L比(13.2±1.8)× 109/L,(132.7±22.3)×109/L比(12.9±1.6)× 109/L,P＜ 0.05].治疗后观察组的血小板计数明显高于对照组(P＜0.05).结论 重组人白细胞介素-11联合环孢素治疗糖皮质激素无效的原发免疫性血小板减少症效果好,值得临床推广应用.
目的 觀察重組人白細胞介素-11聯閤環孢素治療糖皮質激素無效的原髮免疫性血小闆減少癥的臨床療效.方法 選取2009年8月至2011年8月糖皮質激素治療無效的原髮免疫性血小闆減少癥患者35例,根據治療方案分為兩組,對照組13例採用環孢素治療,觀察組22例在環孢素治療基礎上聯閤重組人白細胞介素-11治療.對比觀察兩組治療後的臨床療效及血小闆計數變化情況.結果 觀察組的總有效率為90.9％ (20/22),明顯高于對照組的53.8％(7/13),差異有統計學意義(P＜ 0.05).治療後對照組和觀察組血小闆計數均較治療前明顯升高[(112.5±15.4)×109/L比(13.2±1.8)× 109/L,(132.7±22.3)×109/L比(12.9±1.6)× 109/L,P＜ 0.05].治療後觀察組的血小闆計數明顯高于對照組(P＜0.05).結論 重組人白細胞介素-11聯閤環孢素治療糖皮質激素無效的原髮免疫性血小闆減少癥效果好,值得臨床推廣應用.
목적 관찰중조인백세포개소-11연합배포소치료당피질격소무효적원발면역성혈소판감소증적림상료효.방법 선취2009년8월지2011년8월당피질격소치료무효적원발면역성혈소판감소증환자35례,근거치료방안분위량조,대조조13례채용배포소치료,관찰조22례재배포소치료기출상연합중조인백세포개소-11치료.대비관찰량조치료후적림상료효급혈소판계수변화정황.결과 관찰조적총유효솔위90.9％ (20/22),명현고우대조조적53.8％(7/13),차이유통계학의의(P＜ 0.05).치료후대조조화관찰조혈소판계수균교치료전명현승고[(112.5±15.4)×109/L비(13.2±1.8)× 109/L,(132.7±22.3)×109/L비(12.9±1.6)× 109/L,P＜ 0.05].치료후관찰조적혈소판계수명현고우대조조(P＜0.05).결론 중조인백세포개소-11연합배포소치료당피질격소무효적원발면역성혈소판감소증효과호,치득림상추엄응용.
Objective To observe the effect of recombinant human interleukin-11 combined with ciclosporin in treatment of giucocorticoid invalid idiopathic thrombocytopenic purpura.Methods From August 2009 to August 2011,35 cases with glucocorticoid invalid idiopathic thrombocytopenic purpura patients were divided into two groups according to the treatment method:13 cases in control group were treated with ciclosporin and 22 cases in observation group were treated with recombinant human interleukin-11 at basis of above method.The clinical effect and platelet counts between two groups were compared.Results The total effective rate in observation group was 90.9％ (20/22),which was significantly higher than that in control group [53.8％ (7/13)] (P ＜0.05).After treatment,the platelet counts in both two groups were significantly increased [control group:( 112.5 ± 15.4) × 109/t vs.(13.2 ± 1.8 ) × 109/L; observation group:( 132.7 ± 22.3 ) × 109/L vs.(12.9 ± 1.6) × 109/L] (P ＜ 0.05 ).Moreover,the platelet counts after treatment in observation group was significantly more than that in control group (P ＜ 0.05).Conclusion Recombinant human interleukin-11 combined with ciclosporin in treatment of glucocorticoid invalid idiopathic thrombocytopenic purpura is a good treatment scheme,which can be applied in clinic.
