中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
31期
11-13
,共3页
心力衰竭%骨保护素%系统性炎症反应综合征%核因子-κB受体活化因子配体
心力衰竭%骨保護素%繫統性炎癥反應綜閤徵%覈因子-κB受體活化因子配體
심력쇠갈%골보호소%계통성염증반응종합정%핵인자-κB수체활화인자배체
Heart failure%Osteoprotegerin%Systemic inflammatory response syndrome%Receptor activator of nuclear factor-kappa B ligand
目的 探讨慢性心力衰竭(CHF)患者血浆骨保护素(OPG)及核因子-κB受体活化因子配体(RANKL)水平及临床意义.方法 应用酶联免疫吸附法检测110例CHF患者(CHF组)及80例健康体检者(对照组)血浆OPG、RANKL水平,并进行比较.结果 CHF组血浆OPG水平[(135.91±41.83)ng/L]显著高于对照组[(90.13±29.09)ng/L],差异有统计学意义(P＜0.05).CHF组血浆RANKL水平[(90.82±32.14)ng/L]显著高于对照组[(59.78±20.11)ng/L],差异有统计学意义(P＜0.05);随着NYHA分级的增高,血浆OPG、RANKL水平升高(P＜0.05),CHF患者血浆OPG、RANKL水平与左心室射血分数呈负相关(r=-0.33、-0.36,P＜0.05).结论 CHF患者血浆OPG、RANKL水平升高与心功能损伤程度有关,血浆OPG、RANKL可能参与了CHF的发生、发展过程.
目的 探討慢性心力衰竭(CHF)患者血漿骨保護素(OPG)及覈因子-κB受體活化因子配體(RANKL)水平及臨床意義.方法 應用酶聯免疫吸附法檢測110例CHF患者(CHF組)及80例健康體檢者(對照組)血漿OPG、RANKL水平,併進行比較.結果 CHF組血漿OPG水平[(135.91±41.83)ng/L]顯著高于對照組[(90.13±29.09)ng/L],差異有統計學意義(P＜0.05).CHF組血漿RANKL水平[(90.82±32.14)ng/L]顯著高于對照組[(59.78±20.11)ng/L],差異有統計學意義(P＜0.05);隨著NYHA分級的增高,血漿OPG、RANKL水平升高(P＜0.05),CHF患者血漿OPG、RANKL水平與左心室射血分數呈負相關(r=-0.33、-0.36,P＜0.05).結論 CHF患者血漿OPG、RANKL水平升高與心功能損傷程度有關,血漿OPG、RANKL可能參與瞭CHF的髮生、髮展過程.
목적 탐토만성심력쇠갈(CHF)환자혈장골보호소(OPG)급핵인자-κB수체활화인자배체(RANKL)수평급림상의의.방법 응용매련면역흡부법검측110례CHF환자(CHF조)급80례건강체검자(대조조)혈장OPG、RANKL수평,병진행비교.결과 CHF조혈장OPG수평[(135.91±41.83)ng/L]현저고우대조조[(90.13±29.09)ng/L],차이유통계학의의(P＜0.05).CHF조혈장RANKL수평[(90.82±32.14)ng/L]현저고우대조조[(59.78±20.11)ng/L],차이유통계학의의(P＜0.05);수착NYHA분급적증고,혈장OPG、RANKL수평승고(P＜0.05),CHF환자혈장OPG、RANKL수평여좌심실사혈분수정부상관(r=-0.33、-0.36,P＜0.05).결론 CHF환자혈장OPG、RANKL수평승고여심공능손상정도유관,혈장OPG、RANKL가능삼여료CHF적발생、발전과정.
Objective To explore the plasma levels and clinical significance of osteoprotegerin(OPG)and receptor activator of nuclear factor kappa B ligand(RANKL)in patients with chronic heart failure(CHF).Methods In 110 patients with CHF and 80 normal controls,the plasma levels of OPG and RANKL were measured by enzyme-linked immunosorbentassay method.Results The plasma level of OPG in patients with CHF[(135.91±41.83)ng/L]was significantly higher than that in normal controls[(90.13±29.09)ng/L](P＜0.05).The plasma level of RANKL in patients with CHF[(90.82±32.14)ng/L]was significantly higher than that in normal controls[(59.78±20.11)ng/L](P＜0.05).The plasma levels of OPG and RANKL increased with the augment of NYHA functional ranking(P＜0.05).The plasma levels of OPG and RANKL had negative relationship with left ventricular ejection fraction(r=-0.33 and-0.36,P＜0.05).Conclusions The plasma levels of OPG and RANKL in patients with CHF are elevated and related with heart function.OPG and RANKL may participate in the occurrence and development of CHF.
