中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
z2期
22-24
,共3页
胰岛素抵抗%C反应蛋白%妊娠期糖尿病%白介素12
胰島素牴抗%C反應蛋白%妊娠期糖尿病%白介素12
이도소저항%C반응단백%임신기당뇨병%백개소12
Gestational Diabetes Mellitus%Insulin resistance%CRP%IL-12
目的 探讨炎性介质C反应蛋白(CRP)和白介素12(IL-12)在妊娠期糖尿病(GDM)发病机制中的作用.方法 选择我院诊治的孕妇,妊娠中期服50 g葡萄糖筛查阴性为对照组,50例；50 g葡萄糖筛查阳性、并经75 g葡萄糖耐量试验诊断为GDM孕妇作为GDM组,40例.分別检测两组孕妇血清中CRP、IL-12、胰岛素及空腹血糖(FBS)的水平.结果 GDM组空腹血糖、空腹胰岛素、胰岛素抵抗指数(IRI)、CRP、IL-12均高于对照组[(4.95±0.76) mmol/L比(4.57±0.58) mmol/L、(13.65±1.74)uIU/ml比(8.78±1.65) uIU/ml、(2.91±1.05)比(1.72±0.87)、(5.56±1.24) mg/L比(3.25±1.13) mg/L、(71.47±4.35) pg/ml比(56.03±4.06) pg/ml,P＜0.05],单因素分析结果CRP与IRI呈正相关(r=0.865,P＜ 0.05),IL-12与IRI呈正相关(r=0.913,P＜0.05).结论 CRP及IL-12与IRI呈正相关,可能参与了GDM的发病,促进高血糖发生.
目的 探討炎性介質C反應蛋白(CRP)和白介素12(IL-12)在妊娠期糖尿病(GDM)髮病機製中的作用.方法 選擇我院診治的孕婦,妊娠中期服50 g葡萄糖篩查陰性為對照組,50例；50 g葡萄糖篩查暘性、併經75 g葡萄糖耐量試驗診斷為GDM孕婦作為GDM組,40例.分別檢測兩組孕婦血清中CRP、IL-12、胰島素及空腹血糖(FBS)的水平.結果 GDM組空腹血糖、空腹胰島素、胰島素牴抗指數(IRI)、CRP、IL-12均高于對照組[(4.95±0.76) mmol/L比(4.57±0.58) mmol/L、(13.65±1.74)uIU/ml比(8.78±1.65) uIU/ml、(2.91±1.05)比(1.72±0.87)、(5.56±1.24) mg/L比(3.25±1.13) mg/L、(71.47±4.35) pg/ml比(56.03±4.06) pg/ml,P＜0.05],單因素分析結果CRP與IRI呈正相關(r=0.865,P＜ 0.05),IL-12與IRI呈正相關(r=0.913,P＜0.05).結論 CRP及IL-12與IRI呈正相關,可能參與瞭GDM的髮病,促進高血糖髮生.
목적 탐토염성개질C반응단백(CRP)화백개소12(IL-12)재임신기당뇨병(GDM)발병궤제중적작용.방법 선택아원진치적잉부,임신중기복50 g포도당사사음성위대조조,50례；50 g포도당사사양성、병경75 g포도당내량시험진단위GDM잉부작위GDM조,40례.분별검측량조잉부혈청중CRP、IL-12、이도소급공복혈당(FBS)적수평.결과 GDM조공복혈당、공복이도소、이도소저항지수(IRI)、CRP、IL-12균고우대조조[(4.95±0.76) mmol/L비(4.57±0.58) mmol/L、(13.65±1.74)uIU/ml비(8.78±1.65) uIU/ml、(2.91±1.05)비(1.72±0.87)、(5.56±1.24) mg/L비(3.25±1.13) mg/L、(71.47±4.35) pg/ml비(56.03±4.06) pg/ml,P＜0.05],단인소분석결과CRP여IRI정정상관(r=0.865,P＜ 0.05),IL-12여IRI정정상관(r=0.913,P＜0.05).결론 CRP급IL-12여IRI정정상관,가능삼여료GDM적발병,촉진고혈당발생.
Objective to investigate the relationship between CRP,IL-12 and gestational diabetes mellitus.Methods Fifty normal pregnant women (NGT group) and forty with GDM (GDM group) were enrolled in the study.The serum IL-12、fasting blood sugar、CRP were mesured respectively.Results GDM fasting blood glucose,fasting insulin,insulin resistance index (IRI),CRP,IL-12 were higher than those in the control group [(4.95 ± 0.76 vs 4.57 ± 0.58) mmol/L,(13.65 ± 1.74 vs 8.78 ± 1.65) uIU/ml,(2.91 ± 1.05vs 1.72 ± 0.87),(5.56 ± 1.24 vs 3.25 ± 1.13) mg/L,(71.47 ± 4.35 vs 56.03 ± 4.06) PG,/ml,P ＜ 0.05),the results of single factor analysis of CRP showed a positive correlation with IRI (r =0.865,P ＜ 0.05),IL-12 was positively correlated with IRI (r =0.913,P ＜ 0.05).Conclusions Our study show inflammatory cytokins take part in the genesis of gestational diabetes.Serum levels of IL-12 and is one factor in pathogensis of GDM.
