CAJ | 학술논문

目的观察缬沙坦联合氨氯地平治疗原发性高血压的疗效及红细胞分布宽度的变化.方法选择110例原发性高血压患者为研究对象,按随机数字表法分为治疗组(56例)和对照组(54例),治疗组服用缬沙坦和氨氯地平,对照组服用氨氯地平,两组均治疗4周,比较两组治疗后血压和血常规的变化.结果治疗组显效35例、有效12例、无效9例,总有效率83.9％(47/56).对照组显效31例、有效5例、无效18例,总有效率66.7％(36/54).两组总有效率比较差异有统计学意义(P＜0.05).治疗组治疗后收缩压、舒张压、红细胞计数、红细胞压积、血红蛋白、红细胞分布宽度均低于同期对照组(P＜ 0.01或＜0.05).结论缬沙坦联合氨氯地平治疗原发性高血压,可以协同有效降压,红细胞分布宽度下降,同时降低全血黏度,减少心血管事件发生.
목적 관찰힐사탄연합안록지평치료원발성고혈압적료효급홍세포분포관도적변화.방법 선택110례원발성고혈압환자위연구대상,안수궤수자표법분위치료조(56례)화대조조(54례),치료조복용힐사탄화안록지평,대조조복용안록지평,량조균치료4주,비교량조치료후혈압화혈상규적변화.결과 치료조현효35례、유효12례、무효9례,총유효솔83.9％(47/56).대조조현효31례、유효5례、무효18례,총유효솔66.7％(36/54).량조총유효솔비교차이유통계학의의(P＜0.05).치료조치료후수축압、서장압、홍세포계수、홍세포압적、혈홍단백、홍세포분포관도균저우동기대조조(P＜ 0.01혹＜0.05).결론 힐사탄연합안록지평치료원발성고혈압,가이협동유효강압,홍세포분포관도하강,동시강저전혈점도,감소심혈관사건발생.
Objective To observe the therapeutic effectiveness of valsartan in combination with amlodipine in therapy of essential hypertension and the consequent changes in red cell distribution width (RDW).Methods One hundred and ten patients of hypertension were selected,then randomly divided into treatment group (56 cases) and control group (54 cases).Valsartan and amlodipine were given to the treatment group,while the control group taking amlodipine only.Bp and RBC were carried out before and after treatment.Results Antihypertensive effect of the treatment group were statistically significant compared with the control group (P ＜ 0.05).The consequent RBC,Hct and Hb,RDW level of treatment group decreased dramatically compared with the control group (P ＜ 0.01 or ＜ 0.05).Conclusions Valsartan in combination with amlodipine in ther apy of hypertension is a prospective combination which achieves superior blood pressure control,low level of RDW and blood viscosity,as a result reducing the incidence of cardiovascular events.