中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
2期
34-36
,共3页
骨关节炎%基质金属蛋白酶3%脂联素%滑液%膝关节
骨關節炎%基質金屬蛋白酶3%脂聯素%滑液%膝關節
골관절염%기질금속단백매3%지련소%활액%슬관절
Osteoarthritis%Matrix metalloproteinase 3%Adiponectin%Synovial fluid%Knee joint
目的 探讨基质金属蛋白酶3(MMP-3)和脂联素在膝关节骨关节炎(OA)病变过程中的作用及临床价值.方法 选择90例膝关节OA患者作为OA组,另选择40例单纯膝关节半月板损伤患者作为对照组.膝关节OA患者按Kellgren-Lawrence (KL)标准分为Ⅰ～Ⅳ级,Ⅰ级21例,Ⅱ级27例,Ⅲ级23例,Ⅳ级19例.采用酶联免疫吸附法检测两组患者关节滑液中MMP-3和脂联素水平并进行比较.结果 OA组关节滑液中MMP-3和脂联素水平分别为(27.57±16.53)、(144.04±48.01) ng/L,均高于对照组的(11.27±3.76)、(86.05±28.52) ng/L,差异有统计学意义(t=6.153、8.638,P＜ 0.05).Ⅰ～Ⅳ级膝关节OA患者关节滑液中MMP-3和脂联素水平与对照组比较均上升,Ⅰ、Ⅱ级MMP-3和脂联素水平与对照组比较差异无统计学意义(P＞0.05)；Ⅲ、Ⅳ级MMP-3和脂联素水平与对照组比较差异有统计学意义(P＜0.05)；Ⅳ级MMP-3和脂联素水平与Ⅲ级比较差异有统计学意义(P＜0.05).膝关节OA患者关节滑液中MMP-3水平和脂联素水平呈正相关(r=0.506,P＜0.05).结论 MMP-3和脂联素在膝关节OA患者关节滑液中呈高表达,并且与膝关节OA的病变和进展有关.
目的 探討基質金屬蛋白酶3(MMP-3)和脂聯素在膝關節骨關節炎(OA)病變過程中的作用及臨床價值.方法 選擇90例膝關節OA患者作為OA組,另選擇40例單純膝關節半月闆損傷患者作為對照組.膝關節OA患者按Kellgren-Lawrence (KL)標準分為Ⅰ～Ⅳ級,Ⅰ級21例,Ⅱ級27例,Ⅲ級23例,Ⅳ級19例.採用酶聯免疫吸附法檢測兩組患者關節滑液中MMP-3和脂聯素水平併進行比較.結果 OA組關節滑液中MMP-3和脂聯素水平分彆為(27.57±16.53)、(144.04±48.01) ng/L,均高于對照組的(11.27±3.76)、(86.05±28.52) ng/L,差異有統計學意義(t=6.153、8.638,P＜ 0.05).Ⅰ～Ⅳ級膝關節OA患者關節滑液中MMP-3和脂聯素水平與對照組比較均上升,Ⅰ、Ⅱ級MMP-3和脂聯素水平與對照組比較差異無統計學意義(P＞0.05)；Ⅲ、Ⅳ級MMP-3和脂聯素水平與對照組比較差異有統計學意義(P＜0.05)；Ⅳ級MMP-3和脂聯素水平與Ⅲ級比較差異有統計學意義(P＜0.05).膝關節OA患者關節滑液中MMP-3水平和脂聯素水平呈正相關(r=0.506,P＜0.05).結論 MMP-3和脂聯素在膝關節OA患者關節滑液中呈高錶達,併且與膝關節OA的病變和進展有關.
목적 탐토기질금속단백매3(MMP-3)화지련소재슬관절골관절염(OA)병변과정중적작용급림상개치.방법 선택90례슬관절OA환자작위OA조,령선택40례단순슬관절반월판손상환자작위대조조.슬관절OA환자안Kellgren-Lawrence (KL)표준분위Ⅰ～Ⅳ급,Ⅰ급21례,Ⅱ급27례,Ⅲ급23례,Ⅳ급19례.채용매련면역흡부법검측량조환자관절활액중MMP-3화지련소수평병진행비교.결과 OA조관절활액중MMP-3화지련소수평분별위(27.57±16.53)、(144.04±48.01) ng/L,균고우대조조적(11.27±3.76)、(86.05±28.52) ng/L,차이유통계학의의(t=6.153、8.638,P＜ 0.05).Ⅰ～Ⅳ급슬관절OA환자관절활액중MMP-3화지련소수평여대조조비교균상승,Ⅰ、Ⅱ급MMP-3화지련소수평여대조조비교차이무통계학의의(P＞0.05)；Ⅲ、Ⅳ급MMP-3화지련소수평여대조조비교차이유통계학의의(P＜0.05)；Ⅳ급MMP-3화지련소수평여Ⅲ급비교차이유통계학의의(P＜0.05).슬관절OA환자관절활액중MMP-3수평화지련소수평정정상관(r=0.506,P＜0.05).결론 MMP-3화지련소재슬관절OA환자관절활액중정고표체,병차여슬관절OA적병변화진전유관.
Objective To investigate the expression and clinical significance of matrix metalloproteinase 3 (MMP-3) and adiponectin in synovial fluids of knee osteoarthritis (OA) patients.Methods Ninety knee OA patients (OA group) were divided into Ⅰ-Ⅳ grade by Kellgren-Lawrenee (KL)standard,in which 21 patients of grade Ⅰ,27 patients of grade Ⅱ,23 patients of grade Ⅲ,19 patients of grade Ⅳ.The level of MMP-3 and adiponectin in synovial fluids of knee OA patients and 40 patients with knee meniscus injury (control group) were detected by ELISA method.Results The level of MMP-3 and adiponectin in OA group were (27.57 ± 16.53),(144.04 + 48.01) ng/L,significantly higher than those in control group [(11.27 + 3.76),(86.05 + 28.52) ng/L] (t =6.153,8.638,P ＜ 0.05).The level of MMP-3 and adiponectin in knee OA patients of Ⅰ-1Ⅳ grade were higher than those in control group,but the level of MMP-3 and adiponectin in knee OA patients of Ⅰ-Ⅱ grade had no significant difference compared with control group (P ＞ 0.05),the level of MMP-3 and adiponectin in knee OA patients of Ⅲ-Ⅳ grade had significant difference compared with control group (P ＜ 0.05).The level of MMP-3 was positively correlated with adiponectin (r =0.506,P ＜0.05).Conclusions The MMP-3 and adiponectin have abnormal expression in synovial fluids of knee OA patients.The abnormal expression is associated with occurrence and progression of knee OA.
