中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
6期
15-17
,共3页
伊继峰%许聿新%刘永梅%井庆平%杨立新
伊繼峰%許聿新%劉永梅%井慶平%楊立新
이계봉%허율신%류영매%정경평%양립신
糖尿病视网膜病变%血管内皮生长因子类%Periostin
糖尿病視網膜病變%血管內皮生長因子類%Periostin
당뇨병시망막병변%혈관내피생장인자류%Periostin
Diabetic retinopathy%Vascular endothelial growth factors%Periostin
目的 检测糖尿病视网膜病变(DR)患者血管内皮生长因子(VEGF)和Periostin表达的变化,并探讨其相关的临床意义.方法 选取发生DR的2型糖尿病患者52例(糖尿病DR组)、未发生DR的2型糖尿病患者36例(糖尿病非DR组)以及健康体检者30例(健康对照组),52例DR患者分为非增殖期组(24例)和增殖期组(28例).酶联免疫吸附法检测血清VEGF和Periostin的表达水平.结果 糖尿病非DR组和糖尿病DR组血清VEGF和Periostin表达均显著高于健康对照组[(122.63±28.74)、(163.58±42.37) mg/L比(91.53±19.58) mg/L,(110.15±32.62)、(146.51±41.74) mg/L比(82.26±21.17) mg/L,P＜0.05或＜0.01],并且糖尿病DR组血清VEGF和Periostin表达显著高于糖尿病非DR组(P＜0.05).增殖期组血清VEGF和Periostin表达显著高于非增殖期组[(174.15±47.31) mg/L比(147.66±38.25) mg/L,(160.31±46.43) mg/L比(132.14±35.62) mg/L,P＜0.05].VEGF表达与Periostin表达呈显著正相关(r=0.415,P＜ 0.01).结论 DR患者存在血清VEGF和Periostin高表达,二者的联合检测有利于DR的早期诊断以及病情的监控.
目的 檢測糖尿病視網膜病變(DR)患者血管內皮生長因子(VEGF)和Periostin錶達的變化,併探討其相關的臨床意義.方法 選取髮生DR的2型糖尿病患者52例(糖尿病DR組)、未髮生DR的2型糖尿病患者36例(糖尿病非DR組)以及健康體檢者30例(健康對照組),52例DR患者分為非增殖期組(24例)和增殖期組(28例).酶聯免疫吸附法檢測血清VEGF和Periostin的錶達水平.結果 糖尿病非DR組和糖尿病DR組血清VEGF和Periostin錶達均顯著高于健康對照組[(122.63±28.74)、(163.58±42.37) mg/L比(91.53±19.58) mg/L,(110.15±32.62)、(146.51±41.74) mg/L比(82.26±21.17) mg/L,P＜0.05或＜0.01],併且糖尿病DR組血清VEGF和Periostin錶達顯著高于糖尿病非DR組(P＜0.05).增殖期組血清VEGF和Periostin錶達顯著高于非增殖期組[(174.15±47.31) mg/L比(147.66±38.25) mg/L,(160.31±46.43) mg/L比(132.14±35.62) mg/L,P＜0.05].VEGF錶達與Periostin錶達呈顯著正相關(r=0.415,P＜ 0.01).結論 DR患者存在血清VEGF和Periostin高錶達,二者的聯閤檢測有利于DR的早期診斷以及病情的鑑控.
목적 검측당뇨병시망막병변(DR)환자혈관내피생장인자(VEGF)화Periostin표체적변화,병탐토기상관적림상의의.방법 선취발생DR적2형당뇨병환자52례(당뇨병DR조)、미발생DR적2형당뇨병환자36례(당뇨병비DR조)이급건강체검자30례(건강대조조),52례DR환자분위비증식기조(24례)화증식기조(28례).매련면역흡부법검측혈청VEGF화Periostin적표체수평.결과 당뇨병비DR조화당뇨병DR조혈청VEGF화Periostin표체균현저고우건강대조조[(122.63±28.74)、(163.58±42.37) mg/L비(91.53±19.58) mg/L,(110.15±32.62)、(146.51±41.74) mg/L비(82.26±21.17) mg/L,P＜0.05혹＜0.01],병차당뇨병DR조혈청VEGF화Periostin표체현저고우당뇨병비DR조(P＜0.05).증식기조혈청VEGF화Periostin표체현저고우비증식기조[(174.15±47.31) mg/L비(147.66±38.25) mg/L,(160.31±46.43) mg/L비(132.14±35.62) mg/L,P＜0.05].VEGF표체여Periostin표체정현저정상관(r=0.415,P＜ 0.01).결론 DR환자존재혈청VEGF화Periostin고표체,이자적연합검측유리우DR적조기진단이급병정적감공.
Objective To detect the expressions of vascular endothelial growth factor(VEGF) and Periostin in patients with diabetic retinopathy (DR),and to explore its chnical significance.Methods A total of 52 patients with DR (DR group),36 non-DR diabetic patients (non-DR group) and 30 healthy person (normal control group) were enrolled.The 52 cases of DR patients were divided into non-proliferative DR (PDR) group (non-PDR group,24 cases) and PDR group (28 cases).The expressions of serum VEGF and Periostin were detected with enzyme-linked immunosorbent assay analysis.Results The serum expressions of VEGF and Periostin were significantly higher in non-DR group and DR group than those in normal control group [(122.63 ±28.74),(163.58 ±42.37) mg/L vs.(91.53 ± 19.58) mg/L,(110.15 ±32.62),(146.51 ± 41.74) mg/L vs.(82.26 ± 21.17) mg/L,P ＜ 0.05 or ＜ 0.01].The serum expressions of VEGF and Periostin were significantly higher in DR group than those in non-DR group (P ＜0.05).The serum expressions of VEGF and Periostin were significantly higher in PDR group than those in non-PDR group [(174.15 ±47.31) mg/L vs.(147.66 ±38.25) mag/L,(160.31 ±46.43) mg/L vs.(132.14 ±35.62)mg/L,P ＜ 0.05].The serum expression of VEGF was positively related with Periostin (r =0.415,P ＜ 0.01).Conclusion The high-expressions of VEGF and Periostin are found in DR patients,and which maybe play a key role in the early diagnosis and assessment the progression of DR patients.
