CAJ | 학술논문

目的探讨肺外周性肿瘤的超声造影表现与微血管密度(MVD)的关系.方法利用超声造影研究经病理证实的55例肺外周性肿瘤患者,其中恶性肿瘤40例,良性肿瘤15例,应用时间-强度曲线分析软件分析定量参数(峰值强度和增强强度指数),术后应用免疫组织化学方法测量肿瘤MVD,分析两者相关性.结果恶性肿瘤MVD明显大于良性肿瘤[(24.57±5.93)个/HP比(15.50±2.82)个/HP],差异有统计学意义(P＜0.05);MVD与超声造影的定量参数(峰值强度和增强强度指数)呈显著正相关(P＜0.01).结论超声造影的定量参数与MVD有显著相关性,可作为定量评价肿瘤血管生成的依据.
목적 탐토폐외주성종류적초성조영표현여미혈관밀도(MVD)적관계.방법 이용초성조영연구경병리증실적55례폐외주성종류환자,기중악성종류40례,량성종류15례,응용시간-강도곡선분석연건분석정량삼수(봉치강도화증강강도지수),술후응용면역조직화학방법측량종류MVD,분석량자상관성.결과 악성종류MVD명현대우량성종류[(24.57±5.93)개/HP비(15.50±2.82)개/HP],차이유통계학의의(P＜0.05);MVD여초성조영적정량삼수(봉치강도화증강강도지수)정현저정상관(P＜0.01).결론 초성조영적정량삼수여MVD유현저상관성,가작위정량평개종류혈관생성적의거.
Objective To observe the correlation between contrast-enhanced sonography and microveesel density (MVD) in peripheral lung tumor.Methods Contrast-enhanced sonography was performed in 55 patients with peripheral lung tumor.Among of them,malignant tumor was 40 cases,benign tumor was 15 cases.Analyzed the quantitative parameters (peak intensity,enhanced strength index) by using time-intensity curve (TIC) with computer.MVD was measured by immunohistochemistry after operation.Results The level of MVD in malignant tumor was significantly higher than that in benign tumor [(24.57 ± 5.93)/HP vs.(15.50 ± 2.82)/HP] (P ＜ 0.05).The level of MVD had significant correlation with peak intensity and enhanced strength index (P ＜ 0.01).Conclusions The peak intensity and enhanced strength index have significant correlation with MVD.They are valuable indexes in evaluating angiogenesis in peripheral lung tumor.