中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
9期
36-38
,共3页
血管内皮生长因子类%Wilms瘤%儿童%血清
血管內皮生長因子類%Wilms瘤%兒童%血清
혈관내피생장인자류%Wilms류%인동%혈청
Vascular endothelial growth factors%Wilms tumor%Child%Serum
目的 探讨血清血管内皮生长因子(VEGF)在儿童肾母细胞瘤中的表达,阐明VEGF在肾母细胞瘤侵袭和进展中的作用.方法 回顾性分析手术治疗的30例肾母细胞瘤患儿(肾母细胞瘤组)的临床资料,并选择因感冒发热症状就诊的患儿30例作为对照组,采用酶联免疫吸附法测定两组患儿血清VEGF水平.结果 肾母细胞瘤组患儿血清VEGF水平为(567.90±189.30) ng/L,对照组为(55.46±18.49) ng/L,肾母细胞瘤组显著高于对照组(t=14.757,P＜ 0.05).VEGF的表达与患儿的NWTS分期、预后组织分型和淋巴结转移有相关性(P＜0.01).NWTSⅢ～Ⅳ期、有淋巴结转移、预后组织分型不良的肾母细胞瘤患儿血清VEGF水平明显高于NWTSⅠ～Ⅱ期、无淋巴结转移、预后组织分型良好的肾母细胞瘤患儿(P＜0.01).结论 血清VEGF水平在儿童肾母细胞瘤中呈高表达,肾母细胞瘤患儿血清VEGF水平与NWTS分期、预后组织分型和淋巴结转移有关,高水平的VEGF提示肾母细胞瘤的侵袭和进展,患儿预后不良.
目的 探討血清血管內皮生長因子(VEGF)在兒童腎母細胞瘤中的錶達,闡明VEGF在腎母細胞瘤侵襲和進展中的作用.方法 迴顧性分析手術治療的30例腎母細胞瘤患兒(腎母細胞瘤組)的臨床資料,併選擇因感冒髮熱癥狀就診的患兒30例作為對照組,採用酶聯免疫吸附法測定兩組患兒血清VEGF水平.結果 腎母細胞瘤組患兒血清VEGF水平為(567.90±189.30) ng/L,對照組為(55.46±18.49) ng/L,腎母細胞瘤組顯著高于對照組(t=14.757,P＜ 0.05).VEGF的錶達與患兒的NWTS分期、預後組織分型和淋巴結轉移有相關性(P＜0.01).NWTSⅢ～Ⅳ期、有淋巴結轉移、預後組織分型不良的腎母細胞瘤患兒血清VEGF水平明顯高于NWTSⅠ～Ⅱ期、無淋巴結轉移、預後組織分型良好的腎母細胞瘤患兒(P＜0.01).結論 血清VEGF水平在兒童腎母細胞瘤中呈高錶達,腎母細胞瘤患兒血清VEGF水平與NWTS分期、預後組織分型和淋巴結轉移有關,高水平的VEGF提示腎母細胞瘤的侵襲和進展,患兒預後不良.
목적 탐토혈청혈관내피생장인자(VEGF)재인동신모세포류중적표체,천명VEGF재신모세포류침습화진전중적작용.방법 회고성분석수술치료적30례신모세포류환인(신모세포류조)적림상자료,병선택인감모발열증상취진적환인30례작위대조조,채용매련면역흡부법측정량조환인혈청VEGF수평.결과 신모세포류조환인혈청VEGF수평위(567.90±189.30) ng/L,대조조위(55.46±18.49) ng/L,신모세포류조현저고우대조조(t=14.757,P＜ 0.05).VEGF적표체여환인적NWTS분기、예후조직분형화림파결전이유상관성(P＜0.01).NWTSⅢ～Ⅳ기、유림파결전이、예후조직분형불량적신모세포류환인혈청VEGF수평명현고우NWTSⅠ～Ⅱ기、무림파결전이、예후조직분형량호적신모세포류환인(P＜0.01).결론 혈청VEGF수평재인동신모세포류중정고표체,신모세포류환인혈청VEGF수평여NWTS분기、예후조직분형화림파결전이유관,고수평적VEGF제시신모세포류적침습화진전,환인예후불량.
Objective To investigate the expression of serum vascular endothelial growth factor (VEGF) in children with Wilms tumor,and clarify the effect of VEGF in the invasion and progression of Wilms tumor.Methods Thirty children with Wilms tumor who underwent surgical treatment were retrospectively analyzed as Wilms tumor group,the control group was 30 children who underwent treatment by cold and fever symptoms.The serum VEGF levels of 2 groups were detected by enzyme-linked immunosorbent assay.Results The serum VEGF level of Wilms tumor group was significantly higher than that of control group [(567.90 ± 189.30) ng/L vs.(55.46 ± 18.49) ng/L,t =14.757,P ＜0.05].The expression of serum VEGF was closely related to NWTS stage,prognosis tissue type and lymph node metastasis (P ＜ 0.01).The expressions of serum VEGF in the NWTS Ⅲ-Ⅳ stage,lymph node metastasis and poor prognosis tissue type Wilms tumor were significantly higher than those of NWTS Ⅰ-Ⅱ stage,without lymph node metastasis,good prognosis tissue type Wilms tumor (P＜ 0.01).Conclusions The expression of serum VEGF is high in children with Wilms tumor,the serum VEGF level is closely related to NWTS stage,prognosis tissue type and lymph node metastasis.The high expression of serum VEGF shows the invasion,progression and poor prognosis in children with Wilms tumor.
