中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
10期
11-13
,共3页
动脉粥样硬化%冠状动脉疾病%巨细胞病毒
動脈粥樣硬化%冠狀動脈疾病%巨細胞病毒
동맥죽양경화%관상동맥질병%거세포병독
Atherosclerosis%Coronary disease%Cytomegalovirus
目的 观察人巨细胞病毒(HCMV)在动脉粥样硬化病变中的致病作用,并探讨其相关的临床意义.方法 收集2009年12月至2012年4月诊治的动脉粥样硬化患者134例(观察组),其中冠心病(CHD)患者102例,非CHD患者32例,将102例CHD患者根据HCMV检测结果分为HCMV感染组86例和非HCMV感染组16例,另选取健康体检者40例作为对照组.采用多普勒超声检测颈动脉内膜-中层厚度(IMT),酶联免疫吸附试验法检测血清HCMV-IgM. 结果 观察组HCMV阳性率为77.6％(104/134),显著高于对照组的37.5％(15/40),差异有统计学意义(P＜0.05).观察组中CHD患者和非CHD患者HCMV阳性率分别为84.3％(86/102)和56.2％(18/32),差异有统计学意义(P＜0.05).HCMV感染的动脉粥样硬化患者颈动脉IMT为(1.31 +0.28) mm,显著高于非HCMV感染的(1.14+0.21) mm,差异有统计学意义(P＜0.05).HCMV感染组患者心肌梗死和冠状动脉多支病变的发生率分别为39.5％(34/86)、43.0％ (37/86),显著高于非HCMV感染组的25.0％(4/16)、18.8％(3/16),差异有统计学意义(P＜0.05),而稳定型心绞痛和冠状动脉单支病变的发生率分别为26.7％(23/86)、22.1％(19/86),显著低于非HCMV感染组的43.8％(7/16)、56.2％(9/16),差异有统计学意义(P＜0.05).结论 动脉粥样硬化病变患者中存在HCMV的高感染率,HCMV感染可能参与了动脉粥样硬化病变的发生、发展过程.
目的 觀察人巨細胞病毒(HCMV)在動脈粥樣硬化病變中的緻病作用,併探討其相關的臨床意義.方法 收集2009年12月至2012年4月診治的動脈粥樣硬化患者134例(觀察組),其中冠心病(CHD)患者102例,非CHD患者32例,將102例CHD患者根據HCMV檢測結果分為HCMV感染組86例和非HCMV感染組16例,另選取健康體檢者40例作為對照組.採用多普勒超聲檢測頸動脈內膜-中層厚度(IMT),酶聯免疫吸附試驗法檢測血清HCMV-IgM. 結果 觀察組HCMV暘性率為77.6％(104/134),顯著高于對照組的37.5％(15/40),差異有統計學意義(P＜0.05).觀察組中CHD患者和非CHD患者HCMV暘性率分彆為84.3％(86/102)和56.2％(18/32),差異有統計學意義(P＜0.05).HCMV感染的動脈粥樣硬化患者頸動脈IMT為(1.31 +0.28) mm,顯著高于非HCMV感染的(1.14+0.21) mm,差異有統計學意義(P＜0.05).HCMV感染組患者心肌梗死和冠狀動脈多支病變的髮生率分彆為39.5％(34/86)、43.0％ (37/86),顯著高于非HCMV感染組的25.0％(4/16)、18.8％(3/16),差異有統計學意義(P＜0.05),而穩定型心絞痛和冠狀動脈單支病變的髮生率分彆為26.7％(23/86)、22.1％(19/86),顯著低于非HCMV感染組的43.8％(7/16)、56.2％(9/16),差異有統計學意義(P＜0.05).結論 動脈粥樣硬化病變患者中存在HCMV的高感染率,HCMV感染可能參與瞭動脈粥樣硬化病變的髮生、髮展過程.
목적 관찰인거세포병독(HCMV)재동맥죽양경화병변중적치병작용,병탐토기상관적림상의의.방법 수집2009년12월지2012년4월진치적동맥죽양경화환자134례(관찰조),기중관심병(CHD)환자102례,비CHD환자32례,장102례CHD환자근거HCMV검측결과분위HCMV감염조86례화비HCMV감염조16례,령선취건강체검자40례작위대조조.채용다보륵초성검측경동맥내막-중층후도(IMT),매련면역흡부시험법검측혈청HCMV-IgM. 결과 관찰조HCMV양성솔위77.6％(104/134),현저고우대조조적37.5％(15/40),차이유통계학의의(P＜0.05).관찰조중CHD환자화비CHD환자HCMV양성솔분별위84.3％(86/102)화56.2％(18/32),차이유통계학의의(P＜0.05).HCMV감염적동맥죽양경화환자경동맥IMT위(1.31 +0.28) mm,현저고우비HCMV감염적(1.14+0.21) mm,차이유통계학의의(P＜0.05).HCMV감염조환자심기경사화관상동맥다지병변적발생솔분별위39.5％(34/86)、43.0％ (37/86),현저고우비HCMV감염조적25.0％(4/16)、18.8％(3/16),차이유통계학의의(P＜0.05),이은정형심교통화관상동맥단지병변적발생솔분별위26.7％(23/86)、22.1％(19/86),현저저우비HCMV감염조적43.8％(7/16)、56.2％(9/16),차이유통계학의의(P＜0.05).결론 동맥죽양경화병변환자중존재HCMV적고감염솔,HCMV감염가능삼여료동맥죽양경화병변적발생、발전과정.
Objective To investigate the infection of human cytomegalovirus (HCMV) in patients with atherosclerosis and explore its clinical significance.Methods A total of 134 patients with atherosclerosis (observation group) including 102 patients with coronary heart disease (CHD) and 32 patients with non-CHD from December 2009 to April 2012 were enrolled in this study.The 102 patients with CHD were divided into HCMV infection group (86 cases) and non-HCMV infection group (16 cases).Another 40 healthy person were selected as control group.The carotid intima-media thickness (IMT) was assessed by ultrasonography.The serum HCMV-IgM was measured by enzyme-linked immunosorbent assay.Results The infection rate of HCMV in observation group was 77.6％ (104/134),which was higher than that of 37.5％(15/40) in control group(P ＜ 0.05).The infection rate of HCMV in CHD patients and non-CHD patients was 84.3％(86/102) and 56.2％(18/32),and there was significant difference (P ＜ 0.05).The carotid IMT in HCMV infected atherosclerosis patients was (1.31 + 0.28) mm,which was higher than that of (1.14 ± 0.21)mm in non-HCMV infected atherosclerosis patients (P ＜ 0.05).The incidence of myocardial infarction and multi-vessel lesion in HCMV infection group was higher than that in non-HCMV infection group [39.5％(34/86) vs.25.0％(4/16) and 43.0％(37/86) vs.18.8％(3/16)](P＜ 0.05).The incidence of stable angina pectoris and single-vessel lesion in HCMV infection group was lower than that in non-HCMV infection group [26.7％(23/86) vs.43.8％(7/16) and 22.1％(19/86) vs.56.2％(9/16)](P＜0.05).Conclusion The high-infection rate of HCMV is found in atherosclerosis patients,and it maybe have a close relationship with the occurrence and development of atherosclerosis.
