中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
13期
38-41
,共4页
不宁腿综合征%危险因素%病例对照研究%帕金森病
不寧腿綜閤徵%危險因素%病例對照研究%帕金森病
불저퇴종합정%위험인소%병례대조연구%파금삼병
Restless legs syndrome%Risk factors%Case-control studies%Parkinson disease
目的 探讨老年男性不宁腿综合征(RLS)的危险因素.方法 采用病例对照研究,病例组(148例)为确诊的老年男性RLS患者,按照年龄段分层,随机抽样选取155例非RLS人群作为对照组,比较两组的一般人口学资料(年龄、文化程度、婚姻状况等)、生活习惯(包括体育锻炼情况、烟酒嗜好等)和既往疾病史等.使用SPSS13.0软件进行单因素分析和多因素非条件Logistic逐步回归分析.结果 单因素分析:病例组与对照组帕金森病病史比例比较差异有统计学意义[8.8％(13/148)比3.2％(5/155)](P＜ 0.05),而吸烟、饮酒、体育锻炼、糖尿病病史、周围神经病病史等既往疾病史在两组间比较差异无统计学意义(P＞0.05).病例组血肌酐水平明显高于对照组[(103.92±32.07)μmol/L比(85.35±36.14)μmol/L],差异有统计学意义(P=0.000),而收缩压、舒张压、血红蛋白、空腹血糖在两组间比较差异无统计学意义(P＞0.05).多因素分析:在调整了可能的影响因素后,既往帕金森病病史、周围神经病病史、血肌酐水平是老年男性RLS的独立危险因素,其OR值(95％ CI)分别为5.68(1.046 ～ 30.846)、4.13(1.109 ～ 15.368)、1.02(1.014～ 1.036).结论 既往帕金森病、周围神经病病史和血肌酐水平是老年男性RLS的独立危险因素.
目的 探討老年男性不寧腿綜閤徵(RLS)的危險因素.方法 採用病例對照研究,病例組(148例)為確診的老年男性RLS患者,按照年齡段分層,隨機抽樣選取155例非RLS人群作為對照組,比較兩組的一般人口學資料(年齡、文化程度、婚姻狀況等)、生活習慣(包括體育鍛煉情況、煙酒嗜好等)和既往疾病史等.使用SPSS13.0軟件進行單因素分析和多因素非條件Logistic逐步迴歸分析.結果 單因素分析:病例組與對照組帕金森病病史比例比較差異有統計學意義[8.8％(13/148)比3.2％(5/155)](P＜ 0.05),而吸煙、飲酒、體育鍛煉、糖尿病病史、週圍神經病病史等既往疾病史在兩組間比較差異無統計學意義(P＞0.05).病例組血肌酐水平明顯高于對照組[(103.92±32.07)μmol/L比(85.35±36.14)μmol/L],差異有統計學意義(P=0.000),而收縮壓、舒張壓、血紅蛋白、空腹血糖在兩組間比較差異無統計學意義(P＞0.05).多因素分析:在調整瞭可能的影響因素後,既往帕金森病病史、週圍神經病病史、血肌酐水平是老年男性RLS的獨立危險因素,其OR值(95％ CI)分彆為5.68(1.046 ～ 30.846)、4.13(1.109 ～ 15.368)、1.02(1.014～ 1.036).結論 既往帕金森病、週圍神經病病史和血肌酐水平是老年男性RLS的獨立危險因素.
목적 탐토노년남성불저퇴종합정(RLS)적위험인소.방법 채용병례대조연구,병례조(148례)위학진적노년남성RLS환자,안조년령단분층,수궤추양선취155례비RLS인군작위대조조,비교량조적일반인구학자료(년령、문화정도、혼인상황등)、생활습관(포괄체육단련정황、연주기호등)화기왕질병사등.사용SPSS13.0연건진행단인소분석화다인소비조건Logistic축보회귀분석.결과 단인소분석:병례조여대조조파금삼병병사비례비교차이유통계학의의[8.8％(13/148)비3.2％(5/155)](P＜ 0.05),이흡연、음주、체육단련、당뇨병병사、주위신경병병사등기왕질병사재량조간비교차이무통계학의의(P＞0.05).병례조혈기항수평명현고우대조조[(103.92±32.07)μmol/L비(85.35±36.14)μmol/L],차이유통계학의의(P=0.000),이수축압、서장압、혈홍단백、공복혈당재량조간비교차이무통계학의의(P＞0.05).다인소분석:재조정료가능적영향인소후,기왕파금삼병병사、주위신경병병사、혈기항수평시노년남성RLS적독립위험인소,기OR치(95％ CI)분별위5.68(1.046 ～ 30.846)、4.13(1.109 ～ 15.368)、1.02(1.014～ 1.036).결론 기왕파금삼병、주위신경병병사화혈기항수평시노년남성RLS적독립위험인소.
Objective To investigate the risk factors of restless leg syndrome (RLS) among male elders.Methods A case-control study between 148 old male RLS patients (case group) and 155 non-RLS male elders (control group) was conducted to investigate the risk factors of RLS.The general demographic data (age,education level,marital status,etc.),lifestyle (including physical exercise,smoking and alcohol) and past medical history were compared between two groups.Univariate analysis and non-conditional multivariate Logistic regression analysis was conducted by SPSS 13.0 software.Results In univariate analysis:there was significant difference in history of Parkinson disease between two groups [8.8％ (13/148)vs.3.2％ (5/155)] (P ＜0.05),but there was no significant difference in smoking,alcohol,physical exercise,history of diabetes mellitus and history of peripheral nerve disease between two groups (P ＞ 0.05).The serum creatinine in case group was higher than that in control group [(103.92 ± 32.07) μ mol/L vs.(85.35 ± 36.14) μ tmol/L] (P =0.000),and there was no significant difference in systolic blood pressure,diastolic blood pressure,hemoglobin,fasting blood glucose between two groups (P ＞ 0.05).Multivariate analysis showed that after adjusting for potential confounders,history of Parkinson disease and peripheral nerve disease,and serum creatinine was the independent risk factors of RLS among male elders.The values of OR(95％ CI) were 5.68(1.046-30.846),4.13(1.109-15.368),1.02(1.014-1.036),respectively.Conclusion Histories of Parkinson disease and peripheral nerve disease and serum creatinine are the independent risk factors of RLS among male elders.
