中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
14期
28-30
,共3页
甲状腺结节%肿瘤抑制蛋白质p53%半乳糖凝集素3%细针吸取细胞学
甲狀腺結節%腫瘤抑製蛋白質p53%半乳糖凝集素3%細針吸取細胞學
갑상선결절%종류억제단백질p53%반유당응집소3%세침흡취세포학
Thyroid nodule%Tumor suppresser protein p53%Galectin 3%Fine needle aspiration biopsy
目的 探讨细针吸取细胞学联合免疫组织化学标记物(p53、半乳糖凝集素-3)在细针穿刺组织标本中的表达及其对甲状腺结节鉴别诊断的价值.方法 选择住院行甲状腺结节手术的患者185例,术前均行甲状腺细针吸取细胞学检查和免疫组织化学标记物检测.结果 细针吸取细胞学检查在鉴别甲状腺结节良、恶性方面的敏感度、特异度及诊断准确率分别为75.0％(21/28)、85.4％ (134/157)和83.8％ (155/185).p53、半乳糖凝集素-3在甲状腺恶性病变细针吸取细胞标本中的表达率分别为60.7％(17/28)、85.7％ (24/28),联合检测表达率为50.0％(14/28),在甲状腺良性病变的表达率分别为0、5.1％(8/157),联合检测表达率为1.3％(2/157).p53、半乳糖凝集素-3在甲状腺恶性病变细针吸取细胞标本中的表达率及联合检测表达率明显高于其在甲状腺良性病变的表达率,差异有统计学意义(P＜0.05).细针吸取细胞标本上单独或联合检测p53和半乳糖凝集素-3在鉴别甲状腺结节良、恶性方面的诊断准确率[94.1％(174/185)、93.5％(173/185)和91.4％(169/185)]均明显高于细针吸取细胞学诊断的准确率83.8％ (155/185),差异有统计学意义(P＜0.05).结论 p53、半乳糖凝集素-3与细针吸取细胞学检查联合检测,对术前鉴别诊断甲状腺结节的良、恶性具有较高的辅助价值.
目的 探討細針吸取細胞學聯閤免疫組織化學標記物(p53、半乳糖凝集素-3)在細針穿刺組織標本中的錶達及其對甲狀腺結節鑒彆診斷的價值.方法 選擇住院行甲狀腺結節手術的患者185例,術前均行甲狀腺細針吸取細胞學檢查和免疫組織化學標記物檢測.結果 細針吸取細胞學檢查在鑒彆甲狀腺結節良、噁性方麵的敏感度、特異度及診斷準確率分彆為75.0％(21/28)、85.4％ (134/157)和83.8％ (155/185).p53、半乳糖凝集素-3在甲狀腺噁性病變細針吸取細胞標本中的錶達率分彆為60.7％(17/28)、85.7％ (24/28),聯閤檢測錶達率為50.0％(14/28),在甲狀腺良性病變的錶達率分彆為0、5.1％(8/157),聯閤檢測錶達率為1.3％(2/157).p53、半乳糖凝集素-3在甲狀腺噁性病變細針吸取細胞標本中的錶達率及聯閤檢測錶達率明顯高于其在甲狀腺良性病變的錶達率,差異有統計學意義(P＜0.05).細針吸取細胞標本上單獨或聯閤檢測p53和半乳糖凝集素-3在鑒彆甲狀腺結節良、噁性方麵的診斷準確率[94.1％(174/185)、93.5％(173/185)和91.4％(169/185)]均明顯高于細針吸取細胞學診斷的準確率83.8％ (155/185),差異有統計學意義(P＜0.05).結論 p53、半乳糖凝集素-3與細針吸取細胞學檢查聯閤檢測,對術前鑒彆診斷甲狀腺結節的良、噁性具有較高的輔助價值.
목적 탐토세침흡취세포학연합면역조직화학표기물(p53、반유당응집소-3)재세침천자조직표본중적표체급기대갑상선결절감별진단적개치.방법 선택주원행갑상선결절수술적환자185례,술전균행갑상선세침흡취세포학검사화면역조직화학표기물검측.결과 세침흡취세포학검사재감별갑상선결절량、악성방면적민감도、특이도급진단준학솔분별위75.0％(21/28)、85.4％ (134/157)화83.8％ (155/185).p53、반유당응집소-3재갑상선악성병변세침흡취세포표본중적표체솔분별위60.7％(17/28)、85.7％ (24/28),연합검측표체솔위50.0％(14/28),재갑상선량성병변적표체솔분별위0、5.1％(8/157),연합검측표체솔위1.3％(2/157).p53、반유당응집소-3재갑상선악성병변세침흡취세포표본중적표체솔급연합검측표체솔명현고우기재갑상선량성병변적표체솔,차이유통계학의의(P＜0.05).세침흡취세포표본상단독혹연합검측p53화반유당응집소-3재감별갑상선결절량、악성방면적진단준학솔[94.1％(174/185)、93.5％(173/185)화91.4％(169/185)]균명현고우세침흡취세포학진단적준학솔83.8％ (155/185),차이유통계학의의(P＜0.05).결론 p53、반유당응집소-3여세침흡취세포학검사연합검측,대술전감별진단갑상선결절적량、악성구유교고적보조개치.
Objective To investigate the clinical significance of fine needle aspiration biopsy and immunohistochemical markers in differential diagnosis of thyroid nodule.Methods One hundred and eighty-five cases of thyroid nodule were enrolled in the study.All cases received preoperative fine-needle aspiration biopsy and immunocytochemistry.Results The sensitivity,specificity,diagnostic accuracy of fine needle aspiration biopsy to detect diagnosis of thyroid nodules was 75.0％ (21/28),85.4％ (134/157),83.8％(155/185).The positive rates of p53 and galectin-3 immunodetection in discriminating benign from malignant thyroid nodules were 60.7％ (17/28),85.7％ (24/28),combined with p53 and galectin-3 immunodetection in discriminating benign from malignant thyroid nodules was 50.0％ (14/28).The positive rates of p53 and galectin-3 immunodetection in thyroid adenomas were 0,5.1％ (8/157),combined with p53 and galectin-3 immunodetection in thyroid adenomas was 1.3％ (2/157).The positive rates of p53 and galectin-3 immunodetection in malignant thyroid cytologic specimens,alone or combined were significantly higher than those in thyroid adenomas,there were significant difference(P ＜ 0.05).The diagnostic accuracy of fine needle aspiration biopsy with p53 and galectin-3 immunodetection,alone or combined,in discriminating benign from malignant thyroid nodules [94.1％(174/185),93.5％(173/185),91.4％(169/185)] were higher or equal to those in fine needle aspiration biopsy[83.8％(155/185)],there were significant differences (P ＜0.05).Conclusion Immunodetection of p53 and galectin-3 combined with fine needle aspiration biopsy in the differential diagnosis of thyroid nodules can raise the diagnostic accuracy.
