CAJ | 학술논문

目的探讨血清维生素D与自身免疫性甲状腺疾病之间的相关性.方法共筛选520例健康体检者,检测血钙、血磷、甲状旁腺激素(PTH)、甲状腺过氧化物酶抗体(TPOAb)及25羟维生素D3等相关指标,观察25羟维生素D3减低(≤30 μg/L)的发病率,分析25羟维生素D3减低与自身免疫性甲状腺疾病的相关性.结果所有入选者25羟维生素D3水平为(24.47±7.21)μg/L,25羟维生素D3减低的发病率为61.15％(318/520),TPOAb阳性率为21.54％(112/520).25羟维生素D3≤30 μg/L者TPOAb＞ 50 kU/L和＞100 kU/L比例较25羟维生素D3＞30 μg/L者明显升高[25.79％(82/318)比19.80％(40/202)和9.43％ (30/318)比4.46％ (9/202)],差异均有统计学意义(P＜0.05).Spearman相关分析显示,25羟维生素D3与TPOAb水平呈明显负相关(r=-0.13,P＜0.05).结论维生素D缺乏在人群中非常普遍,并且与自身免疫性甲状腺疾病有一定相关性,这可能与维生素D减低影响机体免疫调节有关,具体机制及补充维生素D后是否可以干预和治疗自身免疫性甲状腺疾病还需进一步研究.
목적 탐토혈청유생소D여자신면역성갑상선질병지간적상관성.방법 공사선520례건강체검자,검측혈개、혈린、갑상방선격소(PTH)、갑상선과양화물매항체(TPOAb)급25간유생소D3등상관지표,관찰25간유생소D3감저(≤30 μg/L)적발병솔,분석25간유생소D3감저여자신면역성갑상선질병적상관성.결과 소유입선자25간유생소D3수평위(24.47±7.21)μg/L,25간유생소D3감저적발병솔위61.15％(318/520),TPOAb양성솔위21.54％(112/520).25간유생소D3≤30 μg/L자TPOAb＞ 50 kU/L화＞100 kU/L비례교25간유생소D3＞30 μg/L자명현승고[25.79％(82/318)비19.80％(40/202)화9.43％ (30/318)비4.46％ (9/202)],차이균유통계학의의(P＜0.05).Spearman상관분석현시,25간유생소D3여TPOAb수평정명현부상관(r=-0.13,P＜0.05).결론 유생소D결핍재인군중비상보편,병차여자신면역성갑상선질병유일정상관성,저가능여유생소D감저영향궤체면역조절유관,구체궤제급보충유생소D후시부가이간예화치료자신면역성갑상선질병환수진일보연구.
Objective To assess the relationship between serum vitamin D and autoimmune thyroid disease.Methods Subjects included total 520 persons receiving regular health examination,and serum calcium,phosphorus,parathyroid hormone (PTH),thyroid peroxidase autoantibody (TPOAb) and 25-dihydroxy vitamin Ds was measured.The incidence of 25-dihydroxy vitamin D3 deficiency (≤30 μ g/L)was observed.The relationship between 25-dihydroxy vitamin D3 deficiency and autoimmune thyroid disease was analyzed.Results The serum 25-dihydroxy vitamin D3 of all the subjects was (24.47 ± 7.21) μ g/L,and the incidence of 25-dihydroxy vitamin D3 deficiency (≤30 μg/L) was 61.15％ (318/520),and the positive rate of TPOAb was 21.54％ (112/520).The proportion of TPOAb ＞ 50 kU/L or ＞ 100 kU/L in subjects with 25-dihydroxy vitamin D3≤30 μ g/L was higher than that in subjects with 25-dihydroxy vitamin D3 ＞ 30 μg/L [25.79％(82/318) vs.19.80％(40/202) and 9.43％(30/318) vs.4.46％(9/202)],and there was significant difference (P ＜ 0.05).The relationship between 25-dihydroxy vitamin D3 and TPOAb was assessed and showed significant inverse correlation (r =-0.13,P ＜0.05).Conclusions Vitamin D deficiency is very common in the population,and autoimmune thyroid disease is related with vitamin D deficiency,which may has impact on the body's immune regulation.Specific mechanism and whether vitamin D supplementation can intervene and treat autoimmune thyroid disease need further study.