中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
17期
1-4
,共4页
李爱琳%刘静%曹红一%苗原%柏兴华%李光
李愛琳%劉靜%曹紅一%苗原%柏興華%李光
리애림%류정%조홍일%묘원%백흥화%리광
食管肿瘤%放射疗法%免疫组织化学
食管腫瘤%放射療法%免疫組織化學
식관종류%방사요법%면역조직화학
Esophageal neoplasms%Radiotherapy%Immunohistoehemistry
目的 探讨Ku70和Ku80在食管鳞癌中的表达及其与同步放化疗敏感性和预后的相关性.方法 应用免疫组织化学方法检测Ku70和Ku80在117例食管鳞癌组织中的表达,并分析其表达与临床病理参数、近期疗效和预后的相关性.结果 Ku70和Ku80在117例食管鳞癌组织中阳性表达率分别为59.0％(69/117)和50.4％(59/117).Ku70和Ku80表达均与食管鳞癌的近期疗效相关(P=0.017、0.012),在完全缓解患者中Ku70和Ku80有更低的阳性表达率[49.2％ (32/65)、40.0％(26/65)].但Ku70和Ku80表达与食管鳞癌患者年龄、CT病变长度、淋巴结转移无相关性(P＞0.05)；Ku70表达和Ku80表达之间也无相关性(P=0.114).Kaplan-Meier分析发现Ku70和Ku80阳性表达的患者具有更差的预后(Ku70:P=0.004；Ku80:P=0.025).Cox单因素分析也得出同样的结果(Ku70:P=0.005,HR=1.971,95％ CI:1.230 ～ 3.159;Ku80:P=0.028,HR=1.659,95％CI:1.057 ～2.605)；但在Cox多因素分析中,仅Ku70表达是影响食管鳞癌患者预后的独立因素(P=0.033).结论 Ku70和Ku80表达上调可降低非手术食管鳞癌患者同步放化疗敏感性,且Ku70表达上调可预测不良预后,提示Ku70和Ku80可作为备选的预测食管鳞癌同步放化疗敏感性的指标.
目的 探討Ku70和Ku80在食管鱗癌中的錶達及其與同步放化療敏感性和預後的相關性.方法 應用免疫組織化學方法檢測Ku70和Ku80在117例食管鱗癌組織中的錶達,併分析其錶達與臨床病理參數、近期療效和預後的相關性.結果 Ku70和Ku80在117例食管鱗癌組織中暘性錶達率分彆為59.0％(69/117)和50.4％(59/117).Ku70和Ku80錶達均與食管鱗癌的近期療效相關(P=0.017、0.012),在完全緩解患者中Ku70和Ku80有更低的暘性錶達率[49.2％ (32/65)、40.0％(26/65)].但Ku70和Ku80錶達與食管鱗癌患者年齡、CT病變長度、淋巴結轉移無相關性(P＞0.05)；Ku70錶達和Ku80錶達之間也無相關性(P=0.114).Kaplan-Meier分析髮現Ku70和Ku80暘性錶達的患者具有更差的預後(Ku70:P=0.004；Ku80:P=0.025).Cox單因素分析也得齣同樣的結果(Ku70:P=0.005,HR=1.971,95％ CI:1.230 ～ 3.159;Ku80:P=0.028,HR=1.659,95％CI:1.057 ～2.605)；但在Cox多因素分析中,僅Ku70錶達是影響食管鱗癌患者預後的獨立因素(P=0.033).結論 Ku70和Ku80錶達上調可降低非手術食管鱗癌患者同步放化療敏感性,且Ku70錶達上調可預測不良預後,提示Ku70和Ku80可作為備選的預測食管鱗癌同步放化療敏感性的指標.
목적 탐토Ku70화Ku80재식관린암중적표체급기여동보방화료민감성화예후적상관성.방법 응용면역조직화학방법검측Ku70화Ku80재117례식관린암조직중적표체,병분석기표체여림상병리삼수、근기료효화예후적상관성.결과 Ku70화Ku80재117례식관린암조직중양성표체솔분별위59.0％(69/117)화50.4％(59/117).Ku70화Ku80표체균여식관린암적근기료효상관(P=0.017、0.012),재완전완해환자중Ku70화Ku80유경저적양성표체솔[49.2％ (32/65)、40.0％(26/65)].단Ku70화Ku80표체여식관린암환자년령、CT병변장도、림파결전이무상관성(P＞0.05)；Ku70표체화Ku80표체지간야무상관성(P=0.114).Kaplan-Meier분석발현Ku70화Ku80양성표체적환자구유경차적예후(Ku70:P=0.004；Ku80:P=0.025).Cox단인소분석야득출동양적결과(Ku70:P=0.005,HR=1.971,95％ CI:1.230 ～ 3.159;Ku80:P=0.028,HR=1.659,95％CI:1.057 ～2.605)；단재Cox다인소분석중,부Ku70표체시영향식관린암환자예후적독립인소(P=0.033).결론 Ku70화Ku80표체상조가강저비수술식관린암환자동보방화료민감성,차Ku70표체상조가예측불량예후,제시Ku70화Ku80가작위비선적예측식관린암동보방화료민감성적지표.
Objective To investigate the correlation between the expression of Ku70 and Ku80 in esophageal squamous cell carcinoma and chemotherapy sensitivity and prognosis.Methods The expression levels of Ku70 and Ku80 in esophageal squamous cell carcinoma were measured by immunohistochemistry.The relationship between the expression of Ku70 or Ku80 and clinical pathology parameters,recent curative effect of concurrent chemoradiation and prognosis of the patients were analyzed.Results The positive expression rate of Ku70 and Ku80 was 59.0％ (69/117) and 50.4％ (59/117) in esophageal squamous cell carcinoma.The expression of Ku70 and Ku80 was significandy related to recent curative effect of esophageal squamous cell carcinomas (P =0.017,0.012).The patients with complete response had lower positive expression rate of Ku70 and Ku80 [49.2％(32/65),40.0％(26/65)].But the expression had no relationship with the age,length of lesions in CT,lymph node metastasis of esophageal squamous cell carcinoma (P ＞0.05).There was no relationship between the expression of Ku70 and Ku80 neither (P =0.114).KaplanMeier analysis found Ku70 and Ku80 had worse prognosis in patients with positive expression (Ku70:P =0.004 ; Ku80:P =0.025).In Cox univariate analysis concluded the same result (Ku70:P =0.005,HR =1.971,95％ CI:1.230-3.159; Ku80:P =0.028,HR =1.659,95％ CI:1.057-2.605); but in Cox multivariate analysis,only Ku70 expression was the independent factor (P =0.033).Conclusions The upregulation of Ku70 and Ku80 is correlated to decreased concurrent chemoradiation sensitivity.In addition,the upregulation of Ku70 is correlated to worse prognosis.Ku70 and Ku80 can be a prediction index for predicting concurrent chemoradiation sensitivity in esophageal squamous cell carcinoma.
