CAJ | 학술논문

目的探讨老年慢性阻塞性肺疾病急性加重(AECOPD)患者单核细胞趋化蛋白(MCP)-1与组织因子(TF)水平及临床意义.方法老年AECOPD患者49例(AECOPD组)和同龄健康志愿者30例(对照组),AECOPD组依据血清降钙素原(PCT)水平分为PCT增高组(PcT≥0.5 μg/L,19例)和PCT正常组(PCT＜ 0.5 μg/L,30例).采用酶联免疫吸附法检测血浆TF和血清MCP-1.结果 AECOPD组血浆TF、血清MCP-1水平分别为(203.6±92.9)、(152.8±99.9) ng/L,显著高于对照组的(136.9±24.3)、(87.5±41.5) ng/L,差异有统计学意义(P＜0.01)；且血浆TF与血清MCP-1呈正相关(r=0.673,P=0.029).PCT增高组血浆TF及血清MCP-1水平分别为(215.3±71.2)、(181.1±61.6) ng/L,显著高于PCT正常组的(192.4±79.7)、(137.3±74.4) ng/L,差异有统计学意义(P＜0.05).结论老年AECOPD患者存在激活的高凝状态,PCT增高者更严重.老年AECOPD患者血浆TF与血清MCP-1水平有一定的相关性.监测血浆TF与血清MCP-1水平对老年AECOPD患者血液高凝状态及心、肺、脑等血栓性疾病的防治有重要意义.
목적 탐토노년만성조새성폐질병급성가중(AECOPD)환자단핵세포추화단백(MCP)-1여조직인자(TF)수평급림상의의.방법 노년AECOPD환자49례(AECOPD조)화동령건강지원자30례(대조조),AECOPD조의거혈청강개소원(PCT)수평분위PCT증고조(PcT≥0.5 μg/L,19례)화PCT정상조(PCT＜ 0.5 μg/L,30례).채용매련면역흡부법검측혈장TF화혈청MCP-1.결과 AECOPD조혈장TF、혈청MCP-1수평분별위(203.6±92.9)、(152.8±99.9) ng/L,현저고우대조조적(136.9±24.3)、(87.5±41.5) ng/L,차이유통계학의의(P＜0.01)；차혈장TF여혈청MCP-1정정상관(r=0.673,P=0.029).PCT증고조혈장TF급혈청MCP-1수평분별위(215.3±71.2)、(181.1±61.6) ng/L,현저고우PCT정상조적(192.4±79.7)、(137.3±74.4) ng/L,차이유통계학의의(P＜0.05).결론 노년AECOPD환자존재격활적고응상태,PCT증고자경엄중.노년AECOPD환자혈장TF여혈청MCP-1수평유일정적상관성.감측혈장TF여혈청MCP-1수평대노년AECOPD환자혈액고응상태급심、폐、뇌등혈전성질병적방치유중요의의.
Objective To investigate the levels and clinical significance of monocyte chemoattractant protein (MCP)-1 and tissue factor (TF) in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Forty-nine elderly patients with AECOPD(AECOPD group) and 30 healthy controls (control group) were selected,and AECOPD group was divided into procalcitonin (PCT) increased group (PCT ≥ 0.5 μ g/L,19 cases) and PCT normal group (PCT ＜ 0.5 μ g/L,30 cases) according to the level of serum PCT.The levels of plasma TF,serum MCP-1 and PCT were determined by enzyme linked immunosorbent assay.Results The levels of plasma TF and serum MCP-1 were (203.6 ± 92.9),(152.8 ±99.9) ng/L in AECOPD group,and (136.9 ±24.3),(87.5 ±41.5) ng/L in control group.There were significant differences in the levels of plasma TF and serum MCP-1 between AECOPD group and control group (P＜0.01).The level of plasma TF was positively correlated with serum MCP-1 (r =0.673,P=0.029).The levels of plasma TF and serum MCP-1 were (215.3 ±71.2),(181.1 ±61.6) ng/L in PCT increased group,and (192.4 ±79.7),(137.3 ±74.4) ng/L in PCT normal group.There were significant differences in the levels of plasma TF and serum MCP-1 between PCT increased group and PCT normal group (P＜0.05).Conclusions In patients with AECOPD,hypercoagulability state is activated,and it is more severe in the patients with increased PCT.The level of plasma TF is positively correlated with serum MCP-1 in patients with AECOPD.To monitor the levels of plasma TF and serum MCP-1 is particularly important for elderly patients of AECOPD with hypercoagulability state to prevent cardiovascular,lungs and cerebrovascular thrombotic disease.