CAJ | 학술논문

目的探讨急性冠状动脉综合征(ACS)合并低T3综合征的临床特点及其与预后的相关性.方法选择ACS合并低游离三碘甲腺原氨酸(FT3)水平的住院患者87例(低FT3组),另外选择64例FT3水平正常的ACS患者作为对照组,均行冠状动脉造影检查.抽取患者空腹静脉血检测FT3、N-末端脑钠肽前体(NT-proBNP)、心肌肌钙蛋白Ⅰ(cTnI)、超敏C反应蛋白(hs-CRP)水平；记录两组单支病变、2支病变与多支病变的患者数量.结果与对照组比较,低FT3组NT-proBNP、cTnI及hs-CRP均显著升高[(1242.14±226.32) ng/L比(1126.36±195.55) ng/L,(0.92±0.23) ng/L比(0.84±0.19) ng/L,(6.46±2.25) mg/L 比(5.71±1.78) mg/L](P＜ 0.01或＜0.05).两组FT3水平均与NT-proBNP、cTnI及hs-CRP呈显著负相关(P＜0.05).两组冠状动脉病变数量比较差异无统计学意义(x2=4.512,P=0.105).结论 ACS患者血清FT3水平与病情的严重程度有良好相关性,与冠状动脉病变数量无明显相关性,对预后有一定预测价值.
목적 탐토급성관상동맥종합정(ACS)합병저T3종합정적림상특점급기여예후적상관성.방법 선택ACS합병저유리삼전갑선원안산(FT3)수평적주원환자87례(저FT3조),령외선택64례FT3수평정상적ACS환자작위대조조,균행관상동맥조영검사.추취환자공복정맥혈검측FT3、N-말단뇌납태전체(NT-proBNP)、심기기개단백Ⅰ(cTnI)、초민C반응단백(hs-CRP)수평；기록량조단지병변、2지병변여다지병변적환자수량.결과 여대조조비교,저FT3조NT-proBNP、cTnI급hs-CRP균현저승고[(1242.14±226.32) ng/L비(1126.36±195.55) ng/L,(0.92±0.23) ng/L비(0.84±0.19) ng/L,(6.46±2.25) mg/L 비(5.71±1.78) mg/L](P＜ 0.01혹＜0.05).량조FT3수평균여NT-proBNP、cTnI급hs-CRP정현저부상관(P＜0.05).량조관상동맥병변수량비교차이무통계학의의(x2=4.512,P=0.105).결론 ACS환자혈청FT3수평여병정적엄중정도유량호상관성,여관상동맥병변수량무명현상관성,대예후유일정예측개치.
Objective To investigate the clinical features of acute coronary syndrome (ACS) combined with low T3 syndrome and its prognosis.Method Eighty-seven ACS patients with low free triiodothyronine (FT3) level (low FT3 group) and additional 64 ACS patients with normal FT3 level(control group) were selected in parallel; all the patients underwent coronary angiography.The contents of FT3,N-terminal pro-brain natriuretic peptide (NT-proBNP),cardiac troponin I (cTnI) and high sensitivity-C reactive protein (hs-CRP) were recorded,and the related factors were evaluated.The number of stenotic vessels was calculated.Results The contents of NT-proBNP,cTnI and hs-CRP in low FT3 group were elevated significantly compared with those in control group [(1242.14 ± 226.32) ng/L vs.(1126.36 ±195.55) ng/L,(0.92 ± 0.23) ng/L vs.(0.84 ± 0.19) ng/L,(6.46 ± 2.25) mg/L vs.(5.71 ± 1.78) mg/L],and there were significant differences (P ＜ 0.01 or ＜ 0.05).The contents of FT3 were negatively correlated with NT-proBNP,cTnI and hs-CRP in two groups (P ＜ 0.05).There was no significant difference in the number of stenotic vessels between two groups (x2 =4.512,P =0.105).Conclusion In patients with ACS,there is a negative correlation between contents of FT3 and the prognosis,but there is no correlation between contents of FT3 and the number of stenotic vessels.