中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
20期
7-10
,共4页
马秋双%张金库%周炳娟%赵文明%赵亚飞
馬鞦雙%張金庫%週炳娟%趙文明%趙亞飛
마추쌍%장금고%주병연%조문명%조아비
乳腺肿瘤%FoxM1蛋白%Cep55蛋白
乳腺腫瘤%FoxM1蛋白%Cep55蛋白
유선종류%FoxM1단백%Cep55단백
Breast neoplasms%FoxM1 protein%Cep55 protein
目的 探讨FoxM1和Cep55蛋白在基底细胞样型乳腺癌(BLBC)中的表达及临床意义.方法 采用免疫组织化学方法检测66例BLBC及其癌旁正常乳腺组织、70例非BLBC组织中FoxM1和Cep55蛋白的表达情况及二者间的关系.结果 BLBC、非BLBC及癌旁正常乳腺组织中FoxM1蛋白阳性表达率分别为77.3％(51/66)、60.0％(42/70)和13.6％(9/66),Cep55蛋白阳性表达率分别为74.2％(49/66)、57.1％(40/70)和16.7％(11/66),BLBC和非BLBC组织均明显高于癌旁正常乳腺组织,BLBC组织明显高于非BLBC组织,差异均有统计学意义(P＜0.05).BLBC组织中FoxM1和Cep55蛋白阳性表达与腋窝淋巴结转移及TNM分期有关,差异均有统计学意义(P＜0.05)；而与年龄、绝经情况、肿瘤大小无关,差异均无统计学意义(P＞0.05).Spearman相关分析结果显示,BLBC组织中FoxM1蛋白与Cep55蛋白表达呈正相关(r=0.259,P＜0.05).结论 FoxM1和Cep55蛋白可能参与了BLBC的发生、发展,并且FoxM1和Cep55蛋白可能有一定的协同作用.
目的 探討FoxM1和Cep55蛋白在基底細胞樣型乳腺癌(BLBC)中的錶達及臨床意義.方法 採用免疫組織化學方法檢測66例BLBC及其癌徬正常乳腺組織、70例非BLBC組織中FoxM1和Cep55蛋白的錶達情況及二者間的關繫.結果 BLBC、非BLBC及癌徬正常乳腺組織中FoxM1蛋白暘性錶達率分彆為77.3％(51/66)、60.0％(42/70)和13.6％(9/66),Cep55蛋白暘性錶達率分彆為74.2％(49/66)、57.1％(40/70)和16.7％(11/66),BLBC和非BLBC組織均明顯高于癌徬正常乳腺組織,BLBC組織明顯高于非BLBC組織,差異均有統計學意義(P＜0.05).BLBC組織中FoxM1和Cep55蛋白暘性錶達與腋窩淋巴結轉移及TNM分期有關,差異均有統計學意義(P＜0.05)；而與年齡、絕經情況、腫瘤大小無關,差異均無統計學意義(P＞0.05).Spearman相關分析結果顯示,BLBC組織中FoxM1蛋白與Cep55蛋白錶達呈正相關(r=0.259,P＜0.05).結論 FoxM1和Cep55蛋白可能參與瞭BLBC的髮生、髮展,併且FoxM1和Cep55蛋白可能有一定的協同作用.
목적 탐토FoxM1화Cep55단백재기저세포양형유선암(BLBC)중적표체급림상의의.방법 채용면역조직화학방법검측66례BLBC급기암방정상유선조직、70례비BLBC조직중FoxM1화Cep55단백적표체정황급이자간적관계.결과 BLBC、비BLBC급암방정상유선조직중FoxM1단백양성표체솔분별위77.3％(51/66)、60.0％(42/70)화13.6％(9/66),Cep55단백양성표체솔분별위74.2％(49/66)、57.1％(40/70)화16.7％(11/66),BLBC화비BLBC조직균명현고우암방정상유선조직,BLBC조직명현고우비BLBC조직,차이균유통계학의의(P＜0.05).BLBC조직중FoxM1화Cep55단백양성표체여액와림파결전이급TNM분기유관,차이균유통계학의의(P＜0.05)；이여년령、절경정황、종류대소무관,차이균무통계학의의(P＞0.05).Spearman상관분석결과현시,BLBC조직중FoxM1단백여Cep55단백표체정정상관(r=0.259,P＜0.05).결론 FoxM1화Cep55단백가능삼여료BLBC적발생、발전,병차FoxM1화Cep55단백가능유일정적협동작용.
Objective To study the expression and clinical significance of FoxM1 and Cep55 protein in basal-like breast carcinoma (BLBC).Methods The expression of FoxM1 and Cep55 protein in 66 cases of BLBC,70 cases of non-BLBC and 66 cases of normal adjacent breast tissue were detected by immunohistochemistry.Their relationship with the clinical pathological factors was analyzed.Results The positive rate of FoxM1 protein in BLBC,non-BLBC and normal adjacent breast tissue was 77.3％ (51/66),60.0％(42/70) and 13.6％(9/66),Cep55 protein was 74.2％(49/66),57.1％(40/70) and 16.7％(11/66),respectively.BLBC and non-BLBC tissue were higher than normal adjacent breast tissue,and BLBC tissue was higher than non-BLBC,there was significant difference (P ＜0.05).In BLBC tissue,the positive expression of FoxM1 and Cep55 protein correlated with lymph nodes metastasis and TNM staging (P ＜0.05),while did not correlate with age,menopause,tumor size (P ＞ 0.05).There was direct correlation between the positive expression of FoxM1 and Cep55 protein (r =0.259,P ＜ 0.05).Conclusion FoxM1 and Cep55 protein may play an important role in the carcinogenesis and development of BLBC,and both of them have the synergistic effect.
