中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
23期
7-10
,共4页
细胞角蛋白多肽-19%甲状腺乳头状癌
細胞角蛋白多肽-19%甲狀腺乳頭狀癌
세포각단백다태-19%갑상선유두상암
Cytokeratin polypeptide 19%Papillary thyroid carcinoma
目的 探讨细胞角蛋白多肽-19(CK19)水平对新发甲状腺乳头状癌(PTC)患者预后的影响.方法 选择60例PTC患者,根据PTC是否复发分为复发组(27例)与非复发组(33例),测定并比较两组患者的CK19水平和临床资料.结果 单因素分析结果显示,两组年龄、女性、吸烟史、毒性弥漫性甲状腺肿病史、职业暴露史、甲状腺过氧化物酶抗体(TPOAb)水平、甲状腺球蛋白抗体(TGAb)水平、三酰甘油(TG)水平及CK19水平比较差异有统计学意义(P＜0.05).多因素Logistic 回归分析结果显示,女性、吸烟史、职业暴露史、TPOAb水平升高、TGAb水平升高、CK19水平升高是患者12个月内PTC复发的独立危险因素(P=0.01).CK19≥4.12 μg/L患者复发率为79.31％(23/29),显著高于CK19 ＜4.12μg/L患者的12.90％(4/31),差异有统计学意义(x2=5.17,P＜0.05).CK19≥4.12 μg/L时,PTC复发率较CK19 ＜4.12 μg/L时显著增加(x2=4.11,P＜0.05).结论 CK19水平升高是PTC患者复发的独立危险因素,可对新发PTC患者复发情况进行有效预测.
目的 探討細胞角蛋白多肽-19(CK19)水平對新髮甲狀腺乳頭狀癌(PTC)患者預後的影響.方法 選擇60例PTC患者,根據PTC是否複髮分為複髮組(27例)與非複髮組(33例),測定併比較兩組患者的CK19水平和臨床資料.結果 單因素分析結果顯示,兩組年齡、女性、吸煙史、毒性瀰漫性甲狀腺腫病史、職業暴露史、甲狀腺過氧化物酶抗體(TPOAb)水平、甲狀腺毬蛋白抗體(TGAb)水平、三酰甘油(TG)水平及CK19水平比較差異有統計學意義(P＜0.05).多因素Logistic 迴歸分析結果顯示,女性、吸煙史、職業暴露史、TPOAb水平升高、TGAb水平升高、CK19水平升高是患者12箇月內PTC複髮的獨立危險因素(P=0.01).CK19≥4.12 μg/L患者複髮率為79.31％(23/29),顯著高于CK19 ＜4.12μg/L患者的12.90％(4/31),差異有統計學意義(x2=5.17,P＜0.05).CK19≥4.12 μg/L時,PTC複髮率較CK19 ＜4.12 μg/L時顯著增加(x2=4.11,P＜0.05).結論 CK19水平升高是PTC患者複髮的獨立危險因素,可對新髮PTC患者複髮情況進行有效預測.
목적 탐토세포각단백다태-19(CK19)수평대신발갑상선유두상암(PTC)환자예후적영향.방법 선택60례PTC환자,근거PTC시부복발분위복발조(27례)여비복발조(33례),측정병비교량조환자적CK19수평화림상자료.결과 단인소분석결과현시,량조년령、녀성、흡연사、독성미만성갑상선종병사、직업폭로사、갑상선과양화물매항체(TPOAb)수평、갑상선구단백항체(TGAb)수평、삼선감유(TG)수평급CK19수평비교차이유통계학의의(P＜0.05).다인소Logistic 회귀분석결과현시,녀성、흡연사、직업폭로사、TPOAb수평승고、TGAb수평승고、CK19수평승고시환자12개월내PTC복발적독립위험인소(P=0.01).CK19≥4.12 μg/L환자복발솔위79.31％(23/29),현저고우CK19 ＜4.12μg/L환자적12.90％(4/31),차이유통계학의의(x2=5.17,P＜0.05).CK19≥4.12 μg/L시,PTC복발솔교CK19 ＜4.12 μg/L시현저증가(x2=4.11,P＜0.05).결론 CK19수평승고시PTC환자복발적독립위험인소,가대신발PTC환자복발정황진행유효예측.
Objective To determine the relationship between plasma cytokeratin polypeptide 19 (CK 19) level and prognosis of patients with first occurrence of papillary thyroid carcinoma (PTC).Methods This prospective trial enrolled 60 patients with PTC.The plasma CK19 level was determined by ELISA and the other clinical data were collected on admission.All patients were followed up for 12 months.The patients were divided into recurrence group (27 patients) and non-recurrence group (33 patients) according to the results of follow-up.Results Single factor analysis showed that age,female,history of smoking,Graves disease,occupational exposure,the level of thyroid peroxidase antibody,thyroglobulin antibody,triglyceride and CK19 between two groups had significant difference (P ＜ 0.05).Multiple factors analysis showed that female,history of smoking,occupational exposure,the level of thyroid peroxidase antibody,thyroglobulin antibody and CK19 were independent risk factors for recurrence (P =0.01).The recurrence rate of CK19 ≥4.12 μg/L patients was 79.31％ (23/29),significantly higher than that in CK19 ＜4.12 μg/L patients [12.90％ (4/31)] (x2 =5.17,P ＜ 0.05).The recurrence rate of CK19 ≥ 4.12 μ g/L was significantly higher than that in CK19 ＜4.12 μ g/L (x2 =4.11,P ＜ 0.05).Conclusions The plasma CK19 level is an independent risk factor for recurrence of PTC patients.It can be used as a significant independent predictor for recurrence of PTC patients.
