中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
6期
42-44
,共3页
呋塞米%甘露醇%脑水肿%托拉塞米
呋塞米%甘露醇%腦水腫%託拉塞米
부새미%감로순%뇌수종%탁랍새미
Furosemide%Mannitol%Brain edema%Torasemide
目的 比较托拉塞米或呋塞米联合甘露醇治疗急性脑出血患者脑水肿的疗效.方法 选择脑出血患者160例,按治疗方法不同分为托拉塞米组和呋塞米组,每组80例,托拉塞米组采用托拉塞米联合20％甘露醇治疗,呋塞米组采用呋塞米联合20％甘露醇治疗,比较两组疗效、甘露醇用量、水肿体积、24h尿量及不良反应.结果 托拉塞米组总有效率明显高于呋塞米组[97.5％(78/80)比77.5％(62/80)],甘露醇用量明显少于呋塞米组[(347.5±32.5) ml比(438.2±30.7) ml],不良反应发生率明显低于呋塞米组[7.5％(6/80)比27.5％(22/80)],差异均有统计学意义(P＜ 0.01或＜0.05).托拉塞米组治疗第7,14天水肿体积明显小于呋塞米组[(21.1±3.4)ml比(23.3±4.8) ml、(17.6±4.5) ml比(22.4±5.6)ml],治疗第3,7,14天24h尿量明显多于呋塞米组[(3684±528) ml比(3 429±592) ml、(3 854±746) ml比(3 185±490)mnl、(3 742±658) ml比(2 251±324) ml],差异均有统计学意义(P＜0.05).结论 托拉塞米在治疗急性脑出血患者的脑水肿方面较呋塞米疗效确切,安全性好.
目的 比較託拉塞米或呋塞米聯閤甘露醇治療急性腦齣血患者腦水腫的療效.方法 選擇腦齣血患者160例,按治療方法不同分為託拉塞米組和呋塞米組,每組80例,託拉塞米組採用託拉塞米聯閤20％甘露醇治療,呋塞米組採用呋塞米聯閤20％甘露醇治療,比較兩組療效、甘露醇用量、水腫體積、24h尿量及不良反應.結果 託拉塞米組總有效率明顯高于呋塞米組[97.5％(78/80)比77.5％(62/80)],甘露醇用量明顯少于呋塞米組[(347.5±32.5) ml比(438.2±30.7) ml],不良反應髮生率明顯低于呋塞米組[7.5％(6/80)比27.5％(22/80)],差異均有統計學意義(P＜ 0.01或＜0.05).託拉塞米組治療第7,14天水腫體積明顯小于呋塞米組[(21.1±3.4)ml比(23.3±4.8) ml、(17.6±4.5) ml比(22.4±5.6)ml],治療第3,7,14天24h尿量明顯多于呋塞米組[(3684±528) ml比(3 429±592) ml、(3 854±746) ml比(3 185±490)mnl、(3 742±658) ml比(2 251±324) ml],差異均有統計學意義(P＜0.05).結論 託拉塞米在治療急性腦齣血患者的腦水腫方麵較呋塞米療效確切,安全性好.
목적 비교탁랍새미혹부새미연합감로순치료급성뇌출혈환자뇌수종적료효.방법 선택뇌출혈환자160례,안치료방법불동분위탁랍새미조화부새미조,매조80례,탁랍새미조채용탁랍새미연합20％감로순치료,부새미조채용부새미연합20％감로순치료,비교량조료효、감로순용량、수종체적、24h뇨량급불량반응.결과 탁랍새미조총유효솔명현고우부새미조[97.5％(78/80)비77.5％(62/80)],감로순용량명현소우부새미조[(347.5±32.5) ml비(438.2±30.7) ml],불량반응발생솔명현저우부새미조[7.5％(6/80)비27.5％(22/80)],차이균유통계학의의(P＜ 0.01혹＜0.05).탁랍새미조치료제7,14천수종체적명현소우부새미조[(21.1±3.4)ml비(23.3±4.8) ml、(17.6±4.5) ml비(22.4±5.6)ml],치료제3,7,14천24h뇨량명현다우부새미조[(3684±528) ml비(3 429±592) ml、(3 854±746) ml비(3 185±490)mnl、(3 742±658) ml비(2 251±324) ml],차이균유통계학의의(P＜0.05).결론 탁랍새미재치료급성뇌출혈환자적뇌수종방면교부새미료효학절,안전성호.
Objective To compare the effect of torasemide or furosemide combined with mannitol in the treatment of acute cerebral hemorrhage patients with cerebral edema.Methods One hundred and sixty patients with cerebral hemorrhage were selected,and divided into torasemide group and furosemide group according to different treatment methods,40 cases in each.The torasemide group was treated with torasemide combined with 20％ mannitol,the furosemide group was treated with furosemide combined with 20％ mannitol.The curative effect,mannitol dosage,edema volume,24 h urine and adverse reactions in two groups were compared.Results The total effective in torasemide group was higher than that in furosemide group [97.5％ (78/80) vs.77.5％ (62/80)],mannitol dosage was less than that in furesemide group [(347.5 ±32.5) ml vs.(438.2 ±30.7) ml],the incidence of adverse reactions was lower than that in furosemide group [7.5％(6/80) vs.27.5％(22/80)],which reached statistical significance (P＜ 0.01 or ＜ 0.05).The edema volume in the 7th,14th day in torasemide group was less than those in furosemide group [(21.1 ±3.4) ml vs.(23.3 ±4.8) ml,(17.6 ±4.5) ml vs.(22.4 ±5.6) ml],the 24 h urine in the 3re,7th,14th day were more than those in furosemide group [(3 684 ±528) ml vs.(3 429 ±592) ml,(3 854 ± 746) ml vs.(3 185 ±490) ml,(3 742 ±t658) ml vs.(2 251 ± 324) ml],which reached statistical significance (P ＜ 0.05).Conclusions Torasemide in treatment of acute cerebral hemorrhage patients has better efficacy and safety.It is better than furosemide.
