CAJ | 학술논문

目的探讨高血压患者胱抑素C(Cys C)水平与颈动脉内膜中层厚度(CIMT)的关系.方法选择101例高血压患者(高血压组)及同期54例健康体检者(对照组),采用颗粒增强免疫比浊法测定两组Cys C水平,超声测定CIMT,分析二者的相关性.结果高血压组Cys C与CIMT均明显高于对照组[(0.92±0.21) mg/L比(0.85±0.20) mg/L、(0.91 ±0.16) mm比(0.65±0.15) mm],差异有统计学意义(P＜ 0.05或＜0.01).多元线性相关分析结果显示无论在总的人群还是在高血压组或对照组,Cys C均与CIMT呈正相关(r=0.412,0.443,0.315,P＜ 0.01).结论血清Cys C与高血压动脉硬化程度相关,提示Cys C有可能参与了动脉粥样硬化的过程.
목적 탐토고혈압환자광억소C(Cys C)수평여경동맥내막중층후도(CIMT)적관계.방법 선택101례고혈압환자(고혈압조)급동기54례건강체검자(대조조),채용과립증강면역비탁법측정량조Cys C수평,초성측정CIMT,분석이자적상관성.결과 고혈압조Cys C여CIMT균명현고우대조조[(0.92±0.21) mg/L비(0.85±0.20) mg/L、(0.91 ±0.16) mm비(0.65±0.15) mm],차이유통계학의의(P＜ 0.05혹＜0.01).다원선성상관분석결과현시무론재총적인군환시재고혈압조혹대조조,Cys C균여CIMT정정상관(r=0.412,0.443,0.315,P＜ 0.01).결론 혈청Cys C여고혈압동맥경화정도상관,제시Cys C유가능삼여료동맥죽양경화적과정.
Objective To explore the correlation between cystatin C (Cys C) and intima-media thickness of carotid artery (CIMT) in patients with hypertension.Methods One hundred and one patients with hypertension (hypertension group) and 54 healthy people (control group) were enrolled in this study.The level of serum Cys C was measured and CIMT was detected by B ultrasound.The correlation between Cys C and CIMT was analyzed.Results The level of Cys C and CIMT in hypertension group were significantly higher than those in control group [(0.92 ±0.21) mg/L vs.(0.85 ±0.20) mg/L,(0.91 ±0.16) mm vs.(0.65 ± 0.15) mm] (P ＜ 0.05 or ＜ 0.01).Multiple linear correlation analysis showed that Cys C and CIMT was positively correlated in total population or hypertension group or control group (r =0.412,0.443,0.315,P ＜0.01).Conclusion Serum Cys C is associated with the degree of hypertension arteriosclerosis,and Cys C may be involved in atherosclerosis.