中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
7期
49-51
,共3页
肾功能衰竭,慢性%心力衰竭,收缩性%肌酸激酶,MB型%肌钙蛋白
腎功能衰竭,慢性%心力衰竭,收縮性%肌痠激酶,MB型%肌鈣蛋白
신공능쇠갈,만성%심력쇠갈,수축성%기산격매,MB형%기개단백
Kidney failure,chronic%Heart failure,systolic%Creatine kinase,MB form%Troponin
目的 探讨慢性肾功能衰竭合并急性左心衰竭患者心肌酶和肌钙蛋白升高的临床意义.方法 选择慢性肾功能衰竭合并急性左心衰竭患者38例(试验组),另选取同期未发生急性左心衰竭的慢性肾功能衰竭患者42例作为对照组,检测两组肌酸激酶同工酶(CK-MB)、天冬氨酸氨基转移酶(AST)、心肌肌钙蛋白Ⅰ(cTnI)、肌酐的变化,并记录患者院内预后.结果 试验组CK-MB、cTnI均较对照组明显升高[(36.23±14.27) U/L比(14.71士8.27)U/L、(11.26±5.04)μg/L比(5.24±2.31)μg/L],差异有统计学意义(P＜0.05);两组AST、肌酐水平均较正常值明显升高,但两组间比较差异无统计学意义(P＞0.05);试验组院内病死率明显高于对照组[47.37％(18/38)比16.67％(7/42)],差异有统计学意义(P＜0.01);多因素分析结果显示,CK-MB、cTnI均是影响慢性肾功能衰竭合并急性左心衰竭患者预后的独立危险因素(r=5.03,3.27,P＜0.05).结论 慢性肾功能衰竭合并急性左心衰竭患者心肌酶和肌钙蛋白的升高对预后有评估作用.
目的 探討慢性腎功能衰竭閤併急性左心衰竭患者心肌酶和肌鈣蛋白升高的臨床意義.方法 選擇慢性腎功能衰竭閤併急性左心衰竭患者38例(試驗組),另選取同期未髮生急性左心衰竭的慢性腎功能衰竭患者42例作為對照組,檢測兩組肌痠激酶同工酶(CK-MB)、天鼕氨痠氨基轉移酶(AST)、心肌肌鈣蛋白Ⅰ(cTnI)、肌酐的變化,併記錄患者院內預後.結果 試驗組CK-MB、cTnI均較對照組明顯升高[(36.23±14.27) U/L比(14.71士8.27)U/L、(11.26±5.04)μg/L比(5.24±2.31)μg/L],差異有統計學意義(P＜0.05);兩組AST、肌酐水平均較正常值明顯升高,但兩組間比較差異無統計學意義(P＞0.05);試驗組院內病死率明顯高于對照組[47.37％(18/38)比16.67％(7/42)],差異有統計學意義(P＜0.01);多因素分析結果顯示,CK-MB、cTnI均是影響慢性腎功能衰竭閤併急性左心衰竭患者預後的獨立危險因素(r=5.03,3.27,P＜0.05).結論 慢性腎功能衰竭閤併急性左心衰竭患者心肌酶和肌鈣蛋白的升高對預後有評估作用.
목적 탐토만성신공능쇠갈합병급성좌심쇠갈환자심기매화기개단백승고적림상의의.방법 선택만성신공능쇠갈합병급성좌심쇠갈환자38례(시험조),령선취동기미발생급성좌심쇠갈적만성신공능쇠갈환자42례작위대조조,검측량조기산격매동공매(CK-MB)、천동안산안기전이매(AST)、심기기개단백Ⅰ(cTnI)、기항적변화,병기록환자원내예후.결과 시험조CK-MB、cTnI균교대조조명현승고[(36.23±14.27) U/L비(14.71사8.27)U/L、(11.26±5.04)μg/L비(5.24±2.31)μg/L],차이유통계학의의(P＜0.05);량조AST、기항수평균교정상치명현승고,단량조간비교차이무통계학의의(P＞0.05);시험조원내병사솔명현고우대조조[47.37％(18/38)비16.67％(7/42)],차이유통계학의의(P＜0.01);다인소분석결과현시,CK-MB、cTnI균시영향만성신공능쇠갈합병급성좌심쇠갈환자예후적독립위험인소(r=5.03,3.27,P＜0.05).결론 만성신공능쇠갈합병급성좌심쇠갈환자심기매화기개단백적승고대예후유평고작용.
Objective To analyze the significance of cardiac enzymes and troponin in chronic kidney failure combined with acute left heart failure patients.Methods Thirty-eight chronic kidney failure combined with acute left heart failure patients were chosen as the experimental group,and 42 chronic kidney failure without acute left heart failure patients were chosen as the control group.The changes of creatine phosphokinase isoenzyme-MB (CK-MB),aspartic transaminase (AST),cardiac troponin Ⅰ (cTnI),creatinine were tested and compared.The prognosis of two groups was recorded.Results The level of CK-MB,cTnI in experimental group were significantly higher than those in control group [(36.23 ± 14.27) U/L vs.(14.71 ±8.27) U/L,(11.26 ± 5.04) μ g/L vs.(5.24 ± 2.31) μ g/L] (P ＜ 0.05).The level of AST,creatinine in two groups were higher than normal value,but there were no significant differences between two groups (P ＞0.05).The fatality rate in experimental group was significantly higher than that in control group [47.37％(18/38)vs.16.67％(7/42)](P＜ 0.01).Multiple stepwise regression analysis showed that CK-MB,cTnI were independent factors of prognosis (r =5.03,3.27,P ＜ 0.05).Conclusion The level of cardiac enzymes and troponin are important for the prognosis of chronic kidney failure combined with acute left heart failure patients.
