中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
8期
20-23
,共4页
结直肠肿瘤%肿瘤分期%预后%血管内皮生长因子C%nm23-H1蛋白
結直腸腫瘤%腫瘤分期%預後%血管內皮生長因子C%nm23-H1蛋白
결직장종류%종류분기%예후%혈관내피생장인자C%nm23-H1단백
Colorectal neoplasms%Neoplasm staging%Prognosis%Vascular endothelial growth factor C%nm23-H1
目的 探讨结直肠癌组织中血管内皮生长因子(VEGF)-C和nm23-H1蛋白的表达水平及其临床意义.方法 选取120例结直肠癌患者肿瘤组织,并以55例癌旁正常组织作为对照;采用免疫组织化学法检测组织中VEGF-C和nm23-H1蛋白的表达水平,分析VEGF-C和nm23-H1蛋白的表达与结直肠癌患者临床特征及预后的关系.结果 VEGF-C在结直肠癌组织中的阳性表达率为71.7％(86/120),高于癌旁正常组织的21.8％(12/55),差异有统计学意义(x2=35.186,P＜0.01).nm23-H1蛋白在结直肠癌组织中的阳性表达率为57.5％ (69/120),低于癌旁正常组织的90.9％ (50/55),差异有统计学意义(x2=18.351,P＜0.01).VEGF-C阳性表达仅与结直肠癌患者的淋巴结转移有相关性(P＜0.05),nm23-H1蛋白阳性表达与结直肠癌患者的淋巴结转移和病理学类型有相关性(P＜ 0.01或＜0.05),VEGF-C和nm23-H1蛋白的阳性表达与性别、年龄、肿瘤直径、原发部位和浸润深度均无相关性(P＞0.05).Spearman相关分析结果显示,在结直肠癌组织中,VEGF-C与nm23-H1蛋白的阳性表达呈负相关(r=-0.472,P＜0.01).结论 VEGF-C和nm23-H1蛋白联合检测对预测结直肠癌患者的预后具有重要的临床意义,但是否可作为判断结直肠癌患者预后的标志物仍需进一步研究.
目的 探討結直腸癌組織中血管內皮生長因子(VEGF)-C和nm23-H1蛋白的錶達水平及其臨床意義.方法 選取120例結直腸癌患者腫瘤組織,併以55例癌徬正常組織作為對照;採用免疫組織化學法檢測組織中VEGF-C和nm23-H1蛋白的錶達水平,分析VEGF-C和nm23-H1蛋白的錶達與結直腸癌患者臨床特徵及預後的關繫.結果 VEGF-C在結直腸癌組織中的暘性錶達率為71.7％(86/120),高于癌徬正常組織的21.8％(12/55),差異有統計學意義(x2=35.186,P＜0.01).nm23-H1蛋白在結直腸癌組織中的暘性錶達率為57.5％ (69/120),低于癌徬正常組織的90.9％ (50/55),差異有統計學意義(x2=18.351,P＜0.01).VEGF-C暘性錶達僅與結直腸癌患者的淋巴結轉移有相關性(P＜0.05),nm23-H1蛋白暘性錶達與結直腸癌患者的淋巴結轉移和病理學類型有相關性(P＜ 0.01或＜0.05),VEGF-C和nm23-H1蛋白的暘性錶達與性彆、年齡、腫瘤直徑、原髮部位和浸潤深度均無相關性(P＞0.05).Spearman相關分析結果顯示,在結直腸癌組織中,VEGF-C與nm23-H1蛋白的暘性錶達呈負相關(r=-0.472,P＜0.01).結論 VEGF-C和nm23-H1蛋白聯閤檢測對預測結直腸癌患者的預後具有重要的臨床意義,但是否可作為判斷結直腸癌患者預後的標誌物仍需進一步研究.
목적 탐토결직장암조직중혈관내피생장인자(VEGF)-C화nm23-H1단백적표체수평급기림상의의.방법 선취120례결직장암환자종류조직,병이55례암방정상조직작위대조;채용면역조직화학법검측조직중VEGF-C화nm23-H1단백적표체수평,분석VEGF-C화nm23-H1단백적표체여결직장암환자림상특정급예후적관계.결과 VEGF-C재결직장암조직중적양성표체솔위71.7％(86/120),고우암방정상조직적21.8％(12/55),차이유통계학의의(x2=35.186,P＜0.01).nm23-H1단백재결직장암조직중적양성표체솔위57.5％ (69/120),저우암방정상조직적90.9％ (50/55),차이유통계학의의(x2=18.351,P＜0.01).VEGF-C양성표체부여결직장암환자적림파결전이유상관성(P＜0.05),nm23-H1단백양성표체여결직장암환자적림파결전이화병이학류형유상관성(P＜ 0.01혹＜0.05),VEGF-C화nm23-H1단백적양성표체여성별、년령、종류직경、원발부위화침윤심도균무상관성(P＞0.05).Spearman상관분석결과현시,재결직장암조직중,VEGF-C여nm23-H1단백적양성표체정부상관(r=-0.472,P＜0.01).결론 VEGF-C화nm23-H1단백연합검측대예측결직장암환자적예후구유중요적림상의의,단시부가작위판단결직장암환자예후적표지물잉수진일보연구.
Objective To discuss the expression and clinical significance of vascular endothelial growth factor (VEGF)-C and nm23-H1 in colorectal carcinoma.Methods Immunohistochemical staining was employed to determine the expression of VEGF-C and nm23-H1 in the carcinoma tissues of 120 cases with colorectal carcinoma and in the adjacent mucosal tissues of 55 cases as control,and analyzed their correlation with cliniopathological features and prognosis.Results The positive expression of VEGF-C in the carcinoma tissues was 71.7％ (86/120),significantly higher than that in the adjacent mucosal tissues [21.8 ％ (12/55)],and there was significant difference (x2 =35.186,P ＜ 0.01).The positive expression of nm23-H1 in the carcinoma tissues was 57.5％ (69/120),significantly lower than that in the adjacent mucosal tissues [90.9％ (50/55)],and there was significant difference (x2 =18.351,P ＜ 0.01).The expression of VEGF-C was significantly correlated with lymph node metastasis (P ＜ 0.05),and the expression of nm23-H 1was significantly correlated with lymph node metastasis and pathological type (P ＜0.01 or ＜0.05).The expression of VEGF-C and nm23-H1 did not show a significant correlation with gender,age,tumor size,tumor site and depth of invasion (P ＞ 0.05).Spearman correlation analysis showed that the expression of VEGF-C was negatively correlated with the expression of nm23-H 1 in colorectal carcinoma (r =-0.472,P ＜0.01).Conclusions The joint detection of VEGF-C and nm23-H1 expression is very promising in prediction of the prognosis of patients with colorectal carcinoma.However,whether it can be used as a marker in prognosis judgment need further investigation.
