CAJ | 학술논문

目的比较核磁共振功能成像(fMRI)与超声造影检查对乳腺癌患者新辅助化疗后疗效评价的准确性.方法 48例经穿刺病理证实乳腺癌患者,行4个周期每周剂量密集型方案(wPC方案)新辅助化疗,分别将化疗前后乳腺fMRI检查、超声造影检查与最终病理诊断进行对比分析,比较两者诊断的准确性.结果 48例新辅助化疗患者,病理完全缓解12例(25.0％,12/48),无缓解13例(27.1％,13/48);超声造影完全缓解20例(41.7％,20/48),无缓解10例(20.8％,10/48);fMRI检查完全缓解17例(35.4％,17/48),无缓解11例(22.9％,11/48);配对r一致性检验组间比较P值均＞ 0.05,表明二者诊断结果与病理诊断有相关性,Kappa检验一致性系数表明fMRI与病理诊断结果之间一致性较好.结论乳腺癌患者术前新辅助化疗后,fMRI与超声造影均可作为疗效评价手段,与超声造影相比,fMRI与病理诊断结果内部一致性更好,可作为首选,超声造影作为疗效评价的补充手段.
목적 비교핵자공진공능성상(fMRI)여초성조영검사대유선암환자신보조화료후료효평개적준학성.방법 48례경천자병리증실유선암환자,행4개주기매주제량밀집형방안(wPC방안)신보조화료,분별장화료전후유선fMRI검사、초성조영검사여최종병리진단진행대비분석,비교량자진단적준학성.결과 48례신보조화료환자,병리완전완해12례(25.0％,12/48),무완해13례(27.1％,13/48);초성조영완전완해20례(41.7％,20/48),무완해10례(20.8％,10/48);fMRI검사완전완해17례(35.4％,17/48),무완해11례(22.9％,11/48);배대r일치성검험조간비교P치균＞ 0.05,표명이자진단결과여병리진단유상관성,Kappa검험일치성계수표명fMRI여병리진단결과지간일치성교호.결론 유선암환자술전신보조화료후,fMRI여초성조영균가작위료효평개수단,여초성조영상비,fMRI여병리진단결과내부일치성경호,가작위수선,초성조영작위료효평개적보충수단.
Objective To investigate the accuracy of functional magnetic resonance imaging(fMRI) and contrast-enhanced ultrasound on evaluation of the breast cancer patients after neoadjuvant chemotherapy.Methods Forty-eight patients with breast cancer who were confirmed by biopsy,undergoing 4 cycles weekly dose-concentrated programs (wPC) neoadjuvant chemotherapy,evaluated the efficacy by fMRI and contrastenhanced ultrasound.Results In pathology,complete remission was 12 cases (25.0％,12/48),non remission was 13 cases (27.1％,13/48).In contrast-enhanced ultrasound,complete remission was 20 cases (41.7％,20/48),non remission was 10 cases (20.8％,10/48).In fMRI,complete remission was 17 cases (35.4％,17/48),non remission was 11 cases (22.9％,11/48).The P values more than 0.05 showed no statistically significant among three methods,the Kappa test showed that fMRI were superior to contrastenhanced ultrasound on evaluating the efficacy of neoadjuvant chemotherapy.Conclusions fMRI and contrast-enhanced ultrasound can be used in evaluating the efficacy of neoadjuvant chemotherapy,however,the data shows fMRI is superior to contrast-enhanced ultrasound.Contrast-enhanced ultrasound must be as the supplementary method.