中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
10期
24-26
,共3页
华法林%老年人%血栓形成%非瓣膜性心房颤动
華法林%老年人%血栓形成%非瓣膜性心房顫動
화법림%노년인%혈전형성%비판막성심방전동
Warfarin%Aged%Thrombosis%Nonvaivuiar atriai fibriiiation
目的 探讨华法林对预防老年非瓣膜性心房颤动患者发生血栓栓塞的影响.方法 选择2010年8月至2011年8月诊治的老年非瓣膜性心房颤动患者92例,按照治疗方案不同分为观察组和对照组,每组46例,对照组给予阿司匹林治疗,观察组给予华法林治疗,观察比较两组患者血栓栓塞发生情况.结果 两组患者左房内径、左室收缩末期内径、左室舒张期内径、左室射血分数比较差异无统计学意义(P＞0.05).观察组临床终点事件(短暂性脑缺血发作、脑栓塞、外周血管栓塞、左房附壁血栓及死亡)发生率为6.52％(3/46),对照组为26.09％(12/46),两组比较差异有统计学意义(x2=6.4519,P=0.0111).观察组服药期间不良反应发生率为10.87％(5/46),对照组为6.52％(3/46),两组比较差异无统计学意义(P＞0.05).结论 采用华法林能够降低老年非瓣膜性心房颤动患者血栓栓塞发生率,但是患者出血并发症值得关注,应密切关注患者国际标准化比值的变化.
目的 探討華法林對預防老年非瓣膜性心房顫動患者髮生血栓栓塞的影響.方法 選擇2010年8月至2011年8月診治的老年非瓣膜性心房顫動患者92例,按照治療方案不同分為觀察組和對照組,每組46例,對照組給予阿司匹林治療,觀察組給予華法林治療,觀察比較兩組患者血栓栓塞髮生情況.結果 兩組患者左房內徑、左室收縮末期內徑、左室舒張期內徑、左室射血分數比較差異無統計學意義(P＞0.05).觀察組臨床終點事件(短暫性腦缺血髮作、腦栓塞、外週血管栓塞、左房附壁血栓及死亡)髮生率為6.52％(3/46),對照組為26.09％(12/46),兩組比較差異有統計學意義(x2=6.4519,P=0.0111).觀察組服藥期間不良反應髮生率為10.87％(5/46),對照組為6.52％(3/46),兩組比較差異無統計學意義(P＞0.05).結論 採用華法林能夠降低老年非瓣膜性心房顫動患者血栓栓塞髮生率,但是患者齣血併髮癥值得關註,應密切關註患者國際標準化比值的變化.
목적 탐토화법림대예방노년비판막성심방전동환자발생혈전전새적영향.방법 선택2010년8월지2011년8월진치적노년비판막성심방전동환자92례,안조치료방안불동분위관찰조화대조조,매조46례,대조조급여아사필림치료,관찰조급여화법림치료,관찰비교량조환자혈전전새발생정황.결과 량조환자좌방내경、좌실수축말기내경、좌실서장기내경、좌실사혈분수비교차이무통계학의의(P＞0.05).관찰조림상종점사건(단잠성뇌결혈발작、뇌전새、외주혈관전새、좌방부벽혈전급사망)발생솔위6.52％(3/46),대조조위26.09％(12/46),량조비교차이유통계학의의(x2=6.4519,P=0.0111).관찰조복약기간불량반응발생솔위10.87％(5/46),대조조위6.52％(3/46),량조비교차이무통계학의의(P＞0.05).결론 채용화법림능구강저노년비판막성심방전동환자혈전전새발생솔,단시환자출혈병발증치득관주,응밀절관주환자국제표준화비치적변화.
Objective To explore the effect of warfarin in prevention of elderly patients with nonvalvular atrial fibrillation thromboembolism.Methods A total of 92 elderly patients with nonvalvular atrial fibrillation from August 2010 to August 2011 were enrolled,and according to the different treatment were divided into observation group and control group,with 46 cases in each group.Control group was given aspirin therapy,observation group was given warfarin therapy,and thromboembolism occurrence were recorded.Results The left atrial diameter,left ventricular systolic diameter,left ventricular diastolic diameter and left heart ejection fraction difference between two groups was not statistically significant (P ＞ 0.05).The terminal event rates (transient ischemic attack,cerebral embolism,peripheral embolism,left atrial thrombi and death) in observation group were statistically lower than those in control group [6.52％ (3/46) vs.26.09％ (12/46)] (x2 =6.4519,P =0.0111).The incidence of adverse reactions in observation group was 10.87％(5/46),in control group was 6.52％(3/46),and there was no statistically significant difference (P＞ 0.05).Conclusions Warfarin can reduce the incidence of elderly patients with nonvalvular atrial fibrillation thromboembolism,but bleeding complications in patients should be concerned with,and international normalized ratio changes of the patients should be paid close attention to.
