中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
10期
30-32
,共3页
贫血%重组人促红细胞生成素%治疗结果
貧血%重組人促紅細胞生成素%治療結果
빈혈%중조인촉홍세포생성소%치료결과
Anemia%Recombinant human erythopoietin%Treatment outcome
目的 探讨重组人促红细胞生成素(rhEPO)在治疗肿瘤相关性贫血中的临床疗效.方法 选择46例肿瘤相关性贫血患者,经皮下注射rhEPO 10 000 U每周3次治疗,无反应者增加至20000 U每周3次,4～6周为1个疗程.结果 28例患者经治疗后血红蛋白(Hb)明显上升,有效率为60.87％(28/46).治疗前Hb为(67.45±2.05) g/L,治疗2周后为(71.05±1.73)g/L,治疗4周后为(78.45±2.20) g/L,治疗6周后为(90.65±3.42)g/L,差异有统计学意义(F=17.702,P＜ 0.05).且随着治疗时间的延长,Hb水平逐渐升高,除治疗前与治疗2周后比较差异无统计学意义外,其余各时间点两两比较差异均有统计学意义(P＜0.05).治疗后患者临床症状均有所好转,偶有头晕、乏力.治疗前KPS评分为40～70分,治疗后为60～90分,较治疗前显著提高.结论 应用rhEPO治疗肿瘤相关性贫血疗效明显,能有效提高Hb水平,改善患者生活质量.
目的 探討重組人促紅細胞生成素(rhEPO)在治療腫瘤相關性貧血中的臨床療效.方法 選擇46例腫瘤相關性貧血患者,經皮下註射rhEPO 10 000 U每週3次治療,無反應者增加至20000 U每週3次,4～6週為1箇療程.結果 28例患者經治療後血紅蛋白(Hb)明顯上升,有效率為60.87％(28/46).治療前Hb為(67.45±2.05) g/L,治療2週後為(71.05±1.73)g/L,治療4週後為(78.45±2.20) g/L,治療6週後為(90.65±3.42)g/L,差異有統計學意義(F=17.702,P＜ 0.05).且隨著治療時間的延長,Hb水平逐漸升高,除治療前與治療2週後比較差異無統計學意義外,其餘各時間點兩兩比較差異均有統計學意義(P＜0.05).治療後患者臨床癥狀均有所好轉,偶有頭暈、乏力.治療前KPS評分為40～70分,治療後為60～90分,較治療前顯著提高.結論 應用rhEPO治療腫瘤相關性貧血療效明顯,能有效提高Hb水平,改善患者生活質量.
목적 탐토중조인촉홍세포생성소(rhEPO)재치료종류상관성빈혈중적림상료효.방법 선택46례종류상관성빈혈환자,경피하주사rhEPO 10 000 U매주3차치료,무반응자증가지20000 U매주3차,4～6주위1개료정.결과 28례환자경치료후혈홍단백(Hb)명현상승,유효솔위60.87％(28/46).치료전Hb위(67.45±2.05) g/L,치료2주후위(71.05±1.73)g/L,치료4주후위(78.45±2.20) g/L,치료6주후위(90.65±3.42)g/L,차이유통계학의의(F=17.702,P＜ 0.05).차수착치료시간적연장,Hb수평축점승고,제치료전여치료2주후비교차이무통계학의의외,기여각시간점량량비교차이균유통계학의의(P＜0.05).치료후환자림상증상균유소호전,우유두훈、핍력.치료전KPS평분위40～70분,치료후위60～90분,교치료전현저제고.결론 응용rhEPO치료종류상관성빈혈료효명현,능유효제고Hb수평,개선환자생활질량.
Objective To explore the application of recombinant human erythropoietin(rhEPO) in the treatment of cancer related anemia.Methods Forty-six cases of patients with cancer related anemia were injected rhEPO 10 000 U subcutaneously three times a week.Non responders increased to 20 000 U three times a week,for 4 to 6 weeks.Results In 28 cases hemoglobin (Hb) increased significantly,and effective rate was 60.87％(28/46).Hb was (67.45 ± 2.05) g/L before treatment,(71.05 ± 1.73) g/L after 2 weeks treatment,(78.45 ±2.20) g/L after 4 weeks treatment,and (90.65 ±3.42) g/L after 6 weeks treatment,the difference was statistically significant (F =17.702,P ＜ 0.05).With the extension of treatment time,the Hb level increased.There was no statistically significant difference before treatment and 2 weeks after treatment,but the differences were statistically significant in other time point (P ＜0.05).Clinical symptoms were improved after treatment with dizziness and fatique occasionally.KPS score were 40-70 scores before treatment,and 60-90 scores after treatment which was significantly higher than that before treatment.Conclusions The rhEPO in the treatment of cancer related anemia has obvious curative effect,and can effectively increase the Hb level and improve quality of life.
