中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
10期
39-40
,共2页
肾功能衰竭,慢性%透明质酸%胶原%层黏连蛋白
腎功能衰竭,慢性%透明質痠%膠原%層黏連蛋白
신공능쇠갈,만성%투명질산%효원%층점련단백
Kidney failure,chronic%Hyaluronic acid%Collagen%Laminin
目的 探讨慢性肾衰竭(CRF)患者血清透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(C-Ⅳ)及层粘连蛋白(LN)检测的临床意义.方法 采用化学发光法检测80例CRF患者(CRF组)及60例健康体检者(对照组)血清HA、PC-Ⅲ、C-Ⅳ及LN水平,并进行比较.结果 CRF组血清HA、PC-Ⅲ、C-Ⅳ水平明显高于对照组[(305.37±41.28) μg/L比(73.26±21.21) μg/L、(236.39±56.63)μg/L比(68.46±32.55)μg/L、(112.54±26.73)μg/L比(55.36±18.44) μg/L],差异均有统计学意义(P＜0.01),两组血清LN水平比较差异无统计学意义(P＞0.05).结论 检测血清HA、PC-Ⅲ、C-Ⅳ水平对于CRF患者的早期诊断及疗效观察有重要临床意义.
目的 探討慢性腎衰竭(CRF)患者血清透明質痠(HA)、Ⅲ型前膠原(PC-Ⅲ)、Ⅳ型膠原(C-Ⅳ)及層粘連蛋白(LN)檢測的臨床意義.方法 採用化學髮光法檢測80例CRF患者(CRF組)及60例健康體檢者(對照組)血清HA、PC-Ⅲ、C-Ⅳ及LN水平,併進行比較.結果 CRF組血清HA、PC-Ⅲ、C-Ⅳ水平明顯高于對照組[(305.37±41.28) μg/L比(73.26±21.21) μg/L、(236.39±56.63)μg/L比(68.46±32.55)μg/L、(112.54±26.73)μg/L比(55.36±18.44) μg/L],差異均有統計學意義(P＜0.01),兩組血清LN水平比較差異無統計學意義(P＞0.05).結論 檢測血清HA、PC-Ⅲ、C-Ⅳ水平對于CRF患者的早期診斷及療效觀察有重要臨床意義.
목적 탐토만성신쇠갈(CRF)환자혈청투명질산(HA)、Ⅲ형전효원(PC-Ⅲ)、Ⅳ형효원(C-Ⅳ)급층점련단백(LN)검측적림상의의.방법 채용화학발광법검측80례CRF환자(CRF조)급60례건강체검자(대조조)혈청HA、PC-Ⅲ、C-Ⅳ급LN수평,병진행비교.결과 CRF조혈청HA、PC-Ⅲ、C-Ⅳ수평명현고우대조조[(305.37±41.28) μg/L비(73.26±21.21) μg/L、(236.39±56.63)μg/L비(68.46±32.55)μg/L、(112.54±26.73)μg/L비(55.36±18.44) μg/L],차이균유통계학의의(P＜0.01),량조혈청LN수평비교차이무통계학의의(P＞0.05).결론 검측혈청HA、PC-Ⅲ、C-Ⅳ수평대우CRF환자적조기진단급료효관찰유중요림상의의.
Objective To investigate the chronic renal failure (CRF) patients with serum hyaluronic acid (HA),procollagen type Ⅲ (PC-Ⅲ),collagen type Ⅳ (C-Ⅳ) and laminin (LN) joint detection of clinical significance.Methods Using chemiluminescence method in 80 cases of CRF patients (CRF group) and 60 healthy (control group) serum HA,PC-Ⅲ,C-Ⅳ and LN for joint detection and comparison.Results The serum HA,PC-Ⅲ,C-Ⅳ in CRF group was significantly higher than that in control group [(305.37 ± 41.28) μ g/L vs.(73.26 ± 21.21) μ g/L,(236.39 ± 56.63) μ g/L vs.(68.46 ± 32.55) μtg/L,(112.54 ±26.73) μg/L vs.(55.36 ± 18.44) μg/L] (P ＜0.01).The LN there was no statistically significant difference between two groups (P ＞ 0.05).Conclusion Detecting HA,PC-Ⅲ,C-Ⅳ for the early diagnosis and therapeutic efficacy observation of patients with CRF has important clinical significance.
