中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
10期
46-49
,共4页
徐新娟%马岩萍%任荣%赵芳%张俊仕%胡广梅
徐新娟%馬巖萍%任榮%趙芳%張俊仕%鬍廣梅
서신연%마암평%임영%조방%장준사%호엄매
基质金属蛋白酶类%基因%高血压%动脉粥样硬化
基質金屬蛋白酶類%基因%高血壓%動脈粥樣硬化
기질금속단백매류%기인%고혈압%동맥죽양경화
Matrix Metalloproteinases%Genes%Hypertension%Atherosclerosis
目的 分析携带不同基质金属蛋白酶(MMP)基因型的原发性高血压(EH)伴发颈动脉粥样硬化(CAS)患者血脂情况.方法 纳入维、汉两个民族488例EH患者,采用聚合酶链反应-限制性片段长度多态性技术测定MMP-2-735 C/T和MMP-3-1171 5A/6A基因多态性,依据是否存在CAS分为CAS组(293例,其中汉族171例,维族122例)和颈动脉正常组(NS组,195例,其中汉族105例,维族90例),对不同基因型携带者进行血脂分析.结果 对于MMP-2基因,汉族CAS组CT+TT基因型低密度脂蛋白胆固醇(LDL-C)高于CC基因型(P＜0.05),高密度脂蛋白胆固醇低于CC基因型(P＜0.05);维族MMp-2 CT+ TT基因型三酰甘油均高于CC基因型(P＜0.05).对于MMP-3基因,汉族NS组6A/6A基因型总胆固醇、LDL-C高于5A/5A+5A/6A基因型(P＜0.05).结论 MMP不同基因型患者血脂水平存在差异,与CAS发生机制可能相关.
目的 分析攜帶不同基質金屬蛋白酶(MMP)基因型的原髮性高血壓(EH)伴髮頸動脈粥樣硬化(CAS)患者血脂情況.方法 納入維、漢兩箇民族488例EH患者,採用聚閤酶鏈反應-限製性片段長度多態性技術測定MMP-2-735 C/T和MMP-3-1171 5A/6A基因多態性,依據是否存在CAS分為CAS組(293例,其中漢族171例,維族122例)和頸動脈正常組(NS組,195例,其中漢族105例,維族90例),對不同基因型攜帶者進行血脂分析.結果 對于MMP-2基因,漢族CAS組CT+TT基因型低密度脂蛋白膽固醇(LDL-C)高于CC基因型(P＜0.05),高密度脂蛋白膽固醇低于CC基因型(P＜0.05);維族MMp-2 CT+ TT基因型三酰甘油均高于CC基因型(P＜0.05).對于MMP-3基因,漢族NS組6A/6A基因型總膽固醇、LDL-C高于5A/5A+5A/6A基因型(P＜0.05).結論 MMP不同基因型患者血脂水平存在差異,與CAS髮生機製可能相關.
목적 분석휴대불동기질금속단백매(MMP)기인형적원발성고혈압(EH)반발경동맥죽양경화(CAS)환자혈지정황.방법 납입유、한량개민족488례EH환자,채용취합매련반응-한제성편단장도다태성기술측정MMP-2-735 C/T화MMP-3-1171 5A/6A기인다태성,의거시부존재CAS분위CAS조(293례,기중한족171례,유족122례)화경동맥정상조(NS조,195례,기중한족105례,유족90례),대불동기인형휴대자진행혈지분석.결과 대우MMP-2기인,한족CAS조CT+TT기인형저밀도지단백담고순(LDL-C)고우CC기인형(P＜0.05),고밀도지단백담고순저우CC기인형(P＜0.05);유족MMp-2 CT+ TT기인형삼선감유균고우CC기인형(P＜0.05).대우MMP-3기인,한족NS조6A/6A기인형총담고순、LDL-C고우5A/5A+5A/6A기인형(P＜0.05).결론 MMP불동기인형환자혈지수평존재차이,여CAS발생궤제가능상관.
Objective To investigate the blood fatty levels in different genotypes of matrix metalloproteinases (MMP) and the carotid atherosclerosis (CAS) in patients with essential hypertension (EH).Methods Four hundred and eighty-eight cases of Han and Uygur in patients with EH were selected,and MMP-2-735 C/T and MMP-3-1171 5A/6A polymorphism was measured by polymerase chain reactionrestriction fragment length polymorphism.They were divided into two groups:EH with CAS group (CAS group,293 cases,Han 171 cases,Uygur 122 cases) and EH without CAS group (NS group,195 cases,Han 105 cases,Uygur 90 cases).Blood fatty factors were analyzed according to the different MMP genotypes.Results According to MMP-2 genotypes,in Hart CAS group,the low density lipoprotein cholesterol (LDL-C) levels in MMP-2 CT+TT genotypes were significantly higher than those in CC genotype(P ＜ 0.05),and high density lipoprotein cholesterol levels were significantly lower than those in CC genotype(P ＜ 0.05); In Uygur CAS group,the triglyceride levels in MMP-2 CT+TT genotypes were significantly higher than those in CC genotype(P ＜ 0.05).According to MMP-3 genotypes in Han NS group,the total cholesterol and LDL-C levels in 6A/6A genotype were significantly higher than those in 5A/5A+5A/6A genotypes (P ＜ 0.05).Conclusion The blood fatty levels are different in patients with different MMP genotypes,which may probably influence the CAS.
