中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
12期
43-45
,共3页
肝炎病毒,乙型%肝炎疫苗,乙型%免疫%乙型肝炎免疫球蛋白
肝炎病毒,乙型%肝炎疫苗,乙型%免疫%乙型肝炎免疫毬蛋白
간염병독,을형%간염역묘,을형%면역%을형간염면역구단백
Hepatitis B virus%Hepatitis B vaccines%Immunity%Hepatitis B immune globulin
目的 评价乙型肝炎疫苗(HepB)联合乙型肝炎免疫球蛋白(HBIG)对乙型肝炎表面抗原(HBsAg)阳性的慢性乙型肝炎病毒(HBV)感染孕妇子女的免疫效果.方法 326例乙型肝炎e抗原(HBeAg)阴性HBV感染孕妇及其分娩的375例子女纳入本研究,记录母亲孕期HBIG使用情况、分娩方式、子女出生后免疫预防措施和喂养方式,并进行HBV标志物比较.结果 375例子女均在出生12h内使用了HBIG,352例(93.9％)出生24 h内接种了第1针HepB,23例(6.1％)均因存在各种新生儿疾病而延迟,但分别在出生后7 ～42 d进行补接种.236例行脐带血检测HBV标志物,39例(16.5％)HBsAg阳性,197例(83.5％)HBsAg阴性,脐带血HBsAg阳性与阴性子女抗-HBs阳性率及抗-HBs中位浓度比较差异无统计学意义(P＞0.05).孕期使用HBIG与未使用HBIG母亲的子女抗-HBs阳性率分别为63.5％(47/74),59.8％(180/301);剖宫产与自然分娩的子女抗-HBs阳性率分别为65.2％(103/158),57.1％(124/217),母乳喂养、混合喂养、人工喂养的子女抗-HBs阳性率分别为62.0％(119/192),58.9％(63/107),59.2％(45/76),差异均无统计学意义(P＞0.05).结论 HBeAg阴性HBV感染孕妇的子女经正规的HBIG联合HepB免疫预防后,不同的分娩方式、喂养方式、孕晚期是否使用HBIG对子女HepB的免疫应答与HBV的母婴传播无影响.
目的 評價乙型肝炎疫苗(HepB)聯閤乙型肝炎免疫毬蛋白(HBIG)對乙型肝炎錶麵抗原(HBsAg)暘性的慢性乙型肝炎病毒(HBV)感染孕婦子女的免疫效果.方法 326例乙型肝炎e抗原(HBeAg)陰性HBV感染孕婦及其分娩的375例子女納入本研究,記錄母親孕期HBIG使用情況、分娩方式、子女齣生後免疫預防措施和餵養方式,併進行HBV標誌物比較.結果 375例子女均在齣生12h內使用瞭HBIG,352例(93.9％)齣生24 h內接種瞭第1針HepB,23例(6.1％)均因存在各種新生兒疾病而延遲,但分彆在齣生後7 ～42 d進行補接種.236例行臍帶血檢測HBV標誌物,39例(16.5％)HBsAg暘性,197例(83.5％)HBsAg陰性,臍帶血HBsAg暘性與陰性子女抗-HBs暘性率及抗-HBs中位濃度比較差異無統計學意義(P＞0.05).孕期使用HBIG與未使用HBIG母親的子女抗-HBs暘性率分彆為63.5％(47/74),59.8％(180/301);剖宮產與自然分娩的子女抗-HBs暘性率分彆為65.2％(103/158),57.1％(124/217),母乳餵養、混閤餵養、人工餵養的子女抗-HBs暘性率分彆為62.0％(119/192),58.9％(63/107),59.2％(45/76),差異均無統計學意義(P＞0.05).結論 HBeAg陰性HBV感染孕婦的子女經正規的HBIG聯閤HepB免疫預防後,不同的分娩方式、餵養方式、孕晚期是否使用HBIG對子女HepB的免疫應答與HBV的母嬰傳播無影響.
목적 평개을형간염역묘(HepB)연합을형간염면역구단백(HBIG)대을형간염표면항원(HBsAg)양성적만성을형간염병독(HBV)감염잉부자녀적면역효과.방법 326례을형간염e항원(HBeAg)음성HBV감염잉부급기분면적375례자녀납입본연구,기록모친잉기HBIG사용정황、분면방식、자녀출생후면역예방조시화위양방식,병진행HBV표지물비교.결과 375례자녀균재출생12h내사용료HBIG,352례(93.9％)출생24 h내접충료제1침HepB,23례(6.1％)균인존재각충신생인질병이연지,단분별재출생후7 ～42 d진행보접충.236례행제대혈검측HBV표지물,39례(16.5％)HBsAg양성,197례(83.5％)HBsAg음성,제대혈HBsAg양성여음성자녀항-HBs양성솔급항-HBs중위농도비교차이무통계학의의(P＞0.05).잉기사용HBIG여미사용HBIG모친적자녀항-HBs양성솔분별위63.5％(47/74),59.8％(180/301);부궁산여자연분면적자녀항-HBs양성솔분별위65.2％(103/158),57.1％(124/217),모유위양、혼합위양、인공위양적자녀항-HBs양성솔분별위62.0％(119/192),58.9％(63/107),59.2％(45/76),차이균무통계학의의(P＞0.05).결론 HBeAg음성HBV감염잉부적자녀경정규적HBIG연합HepB면역예방후,불동적분면방식、위양방식、잉만기시부사용HBIG대자녀HepB적면역응답여HBV적모영전파무영향.
Objective To evaluate the immune effect of combined immunization for newborns of pregnant women with HBeAg-negative chronic hepatitis B.Methods Three hundred and seventy-five cases of children given birth by 326 cases of HBeAg-negative HBV-infected pregnant women were enrolled in this study.The usage of hepatitis B immunoglobulin (HBIG) during pregnancy,mode of delivery,the child's immunization measures after the birth and feeding patterns were recorded,and compared the HBV markers.Results All of 375 cases of children were given HBIG after delivery for 12 h,352 (93.9％) cases of children were given the first time of hepatitis B vaccines(HepB) after delivery for 24 h,and 23 (6.1％) cases of children were delayed because of all kinds of neonatal disease,but they were given vaccination after delivery for 7-42 d.Two hundred and thirty-six cases of cord blood were detected for HBV markers,39 (16.5％) cases were HBsAg positive,197 (83.5％) cases were HBsAg negative.The positive rate of anti-HBs and the meta-concentration of anti-HBs in the child with HBsAg positive and HBsAg negative of cord blood had no significant difference (P ＞ 0.05).The positive rate of anti-HBs of children whose mothers used HBIG or not during pregnancy were 63.5％ (47/74),59.8％(180/301).The positive rate of anti-HBs in cesarean section group and the nature delivery group were 65.2％ (103/158),57.1％ (124/217).The positive rate of anti-HBs in breast feeding,mixed feeding and artificial feeding group were 62.0％ (119/192),58.9％ (63/107),59.2％(45/76).There was no significant difference(P ＞ 0.05).Conclusions After normal HBIG combined HepB,different mode of delivery,feeding,third trimester whether given HBIG have no effect on the newborns of pregnant women with HBeAg-negative chronic hepatitis B.
