CAJ | 학술논문

目的探讨幽门螺杆菌(Hp)感染与冠心病患者颈动脉斑块的相关性以及颈动脉斑块形成的相关因素.方法通过对209例患者进行13C尿素呼气试验(13C-UBT)以评估Hp感染与否,将患者分为感染组(101例)及非感染组(108例),运用彩色多普勒超声仪了解各组颈动脉斑块情况,同时测定各组患者血浆同型半胱氨酸(Hcy)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、纤维蛋白原(Fbg)、高敏C-反应蛋白(hs-CRP)水平,并进行比较.结果感染组颈动脉斑块检出率(69.31％,70/101)大于非感染组(55.56％,60/108),差异有统计学意义(P=0.040);感染组hs-CRP水平[(3.91±1.91) mg/L]与非感染组[(2.65±1.15) mg/L]比较差异有统计学意义(P=0.041);感染组与非感染组血浆Hcy、TC、LDL-C、Fbg水平比较差异无统计学意义(P＞ 0.05);Logistic回归分析显示:Hp感染是冠心病患者发生颈动脉斑块的危险因素之一;Hp感染程度对颈动脉斑块检出率无影响.结论 Hp感染阳性的冠心病患者可能有更高的颈动脉斑块检出率,这一结果与Hcy、LDL-C、Fbg、TC水平无关;Hp感染是冠心病患者发生颈动脉斑块的危险因素;Hp感染的严重程度对颈动脉斑块检出率无明显影响.
목적 탐토유문라간균(Hp)감염여관심병환자경동맥반괴적상관성이급경동맥반괴형성적상관인소.방법 통과대209례환자진행13C뇨소호기시험(13C-UBT)이평고Hp감염여부,장환자분위감염조(101례)급비감염조(108례),운용채색다보륵초성의료해각조경동맥반괴정황,동시측정각조환자혈장동형반광안산(Hcy)、총담고순(TC)、저밀도지단백담고순(LDL-C)、섬유단백원(Fbg)、고민C-반응단백(hs-CRP)수평,병진행비교.결과 감염조경동맥반괴검출솔(69.31％,70/101)대우비감염조(55.56％,60/108),차이유통계학의의(P=0.040);감염조hs-CRP수평[(3.91±1.91) mg/L]여비감염조[(2.65±1.15) mg/L]비교차이유통계학의의(P=0.041);감염조여비감염조혈장Hcy、TC、LDL-C、Fbg수평비교차이무통계학의의(P＞ 0.05);Logistic회귀분석현시:Hp감염시관심병환자발생경동맥반괴적위험인소지일;Hp감염정도대경동맥반괴검출솔무영향.결론 Hp감염양성적관심병환자가능유경고적경동맥반괴검출솔,저일결과여Hcy、LDL-C、Fbg、TC수평무관;Hp감염시관심병환자발생경동맥반괴적위험인소;Hp감염적엄중정도대경동맥반괴검출솔무명현영향.
Objective To explore the relationship of Helicobacter pylori (Hp) infection and carotid plaques in patients with coronary heart disease and analyze the related factors of carotid plaques.Methods This study enrolled 209 patients.13C-urea breath test (13C-UBT) was used to assess Hp infection.Based on the results of 13C-UBT,patients were divided into infection-positive group (101 patients) and infection-negative group (108 patients).The incidence of carotid plaques was detected by color Doppler,and plasma homocysteine (Hcy),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),fibrinogen (Fbg),high sensitivity C reactive protein (hs-CRP) were measured and compared.Results The incidence of carotid plaques in infection-positive group(69.31％,70/101) was higher than that in infection-negative group (55.56％,60/108),and there was significant difference (P =0.040).There was significant difference in hs-CRP between infection-positive group and infection-negative group [(3.91 ± 1.91) mg/L vs.(2.65 ± 1.15)mg/L] (P =0.041).There were no significant difference in Hcy,TC,LDL-C,Fbg between infection-positive group and infection-negative group (P ＞ 0.05).Logistic regression analysis showed that Hp infection was correlated with carotid plaques in patients with coronary heart disease.The severity of Hp infection had no significant effect on the incidence of carotid plaques.Conclusions Hp infection-positive patients with coronary heart disease may have a higher incidence of carotid plaque,regardless of Hcy,LDL-C,Fbg and TC level.This study shows that Hp is correlated with carotid plaque.The severity of Hp infection has no significant effect on the incidence of carotid plaque.