CAJ | 학술논문

目的研究局部亚低温治疗对急性脑出血患者血浆脑钠肽的影响.方法将60例急性脑出血患者按照随机数字表法分为局部亚低温组(30例)和常规治疗组(30例),常规治疗组给予常规治疗,局部亚低温组在常规治疗的基础上加用局部亚低温治疗.在入院当天和治疗第3,7,14天采用美国国立卫生研究院卒中量表(NIHSS)评价神经功能缺损情况,在入院当天和治疗第3,14天检测血浆脑钠肽;治疗第14天判断疗效.结果两组入院当天血浆脑钠肽比较差异无统计学意义(P＞0.05),局部亚低温组治疗第3,14天血浆脑钠肽明显低于常规治疗组[(153.47±32.01) ng/L比(187.45±40.21) ng/L和(111.02±38.27) ng/L比(139.71±29.53) ng/L],差异有统计学意义(P＜0.01或＜0.05).两组入院当天和治疗第3天NIHSS评分比较差异无统计学意义(P＞0.05),局部亚低温组治疗第7,14天NIHSS评分明显低于常规治疗组[(13.84±6.00)分比(16.59±4.62)分和(9.23±4.48)分比(13.02±6.76)分],差异有统计学意义(P＜0.01).局部亚低温组总有效率明显高于常规治疗组[90.0％(27/30)比66.7％(20/30)],差异有统计学意义(P＜0.05).结论局部亚低温治疗可显著改善急性脑出血患者神经功能缺损情况,并降低血浆脑钠肽浓度,提高疗效.
목적 연구국부아저온치료대급성뇌출혈환자혈장뇌납태적영향.방법 장60례급성뇌출혈환자안조수궤수자표법분위국부아저온조(30례)화상규치료조(30례),상규치료조급여상규치료,국부아저온조재상규치료적기출상가용국부아저온치료.재입원당천화치료제3,7,14천채용미국국립위생연구원졸중량표(NIHSS)평개신경공능결손정황,재입원당천화치료제3,14천검측혈장뇌납태;치료제14천판단료효.결과 량조입원당천혈장뇌납태비교차이무통계학의의(P＞0.05),국부아저온조치료제3,14천혈장뇌납태명현저우상규치료조[(153.47±32.01) ng/L비(187.45±40.21) ng/L화(111.02±38.27) ng/L비(139.71±29.53) ng/L],차이유통계학의의(P＜0.01혹＜0.05).량조입원당천화치료제3천NIHSS평분비교차이무통계학의의(P＞0.05),국부아저온조치료제7,14천NIHSS평분명현저우상규치료조[(13.84±6.00)분비(16.59±4.62)분화(9.23±4.48)분비(13.02±6.76)분],차이유통계학의의(P＜0.01).국부아저온조총유효솔명현고우상규치료조[90.0％(27/30)비66.7％(20/30)],차이유통계학의의(P＜0.05).결론 국부아저온치료가현저개선급성뇌출혈환자신경공능결손정황,병강저혈장뇌납태농도,제고료효.
Objective To study the effect of local mild hypothermia on serum brain natriuretic peptide (BNP) in patients with acute intracerebral hemorrhage.Methods Sixty patients with acute intracerebral hemorrhage were divided into local mild hypothermia group (30 cases) and routine therapy group (30 cases) by random digits table method.Routine therapy group was given conventional therapy,and local mild hypothermia group was given local mild hypothermia treatment besides conventional therapy.The neurologic impairment was evaluated according to American National Institute of Health Stroke Scale (NIHSS) scores on admission,and on the 3rd,7th and 14th day after treatment.Serum BNP levels in patients were determined dynamically on admission,and on the 3rd and 14th day after treatment.The effect was evaluated on the 14th day after treatment.Results There was no significant difference in serum BNP on admission between two groups (P ＞ 0.05).Serum BNP on the 3rd,14th day after treatment in local mild hypothermia group was lower than that in routine therapy group[(153.47 ± 32.01) ng/L vs.(187.45 ± 40.21)ng/L and (111.02 ± 38.27) ng/L vs.(139.71 ± 29.53) ng/L],and there was significant difference(P ＜ 0.01 or ＜ 0.05).There was no significant difference in NIHSS scores on admission and on the 3rd day after treatment between two groups (P ＞0.05).NIHSS scores on the 7th and 14th day after treatment in local mild hypothermia group was lower than that in routine therapy group [(13.84 ± 6.00) scores vs.(16.59 ± 4.62)scores and (9.23 ± 4.48) scores vs.(13.02 ± 6.76) scores],and there was significant difference (P ＜ 0.01).The total effective power in local mild hypothermia group was higher than that in routine therapy group[90.0％(27/30) vs.66.7％ (20/30)],and there was significant difference (P ＜ 0.05).Conclusions The local mild hypothermia therapy can not only significantly improve the defect of nerve function in patients with acute intracerebral hemorrhage but also reduce the serum BNP.It can improve the curative effect in patients with acute intracerebral hemorrhage.