中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
13期
39-41
,共3页
糖尿病,2型%颈动脉%糖化血红蛋白
糖尿病,2型%頸動脈%糖化血紅蛋白
당뇨병,2형%경동맥%당화혈홍단백
Diabetes mellitus,type 2%Carotid arteries%Glycosylated hemoglobin
目的 研究糖尿病患者不同糖化血红蛋白(HbA1c)水平对颈动脉内皮细胞功能的影响.方法 选取2型糖尿病患者120例,根据HbA1c水平分组,6％≤HbA1c＜7％为第1组(30例),7％≤HbA1c＜8％为第2组(31例),8％≤HbA1c＜9％为第3组(29例),HbA1c≥9％为第4组(30例).分别进行血管内皮功能指标的检测以及颈动脉彩色多普勒超声检查并记录.结果 四组血管内皮功能指标内皮素1(ET-1)与一氧化氮(NO)比较差异有统计学意义(P＜0.01),两两比较,第4组ET-1与NO最高[(89.3±19.2)ng/L、(59.5±9.3)μmol/L],其次为第3组[(85.9±16.4)ng/L、(56.4±8.9)μmol/L]和第2组[(83.4±17.3) ng/L、(52.3±8.3)μmol/L],差异有统计学意义(P＜0.05).四组颈动脉内膜-中层厚度(IMT)比较差异有统计学意义(P＜0.01),两两比较,第4组颈动脉IMT最大[(2.90±0.62) mm],其次为第3组[(2.40±0.73) mm]和第2组[(1.90±0.42) mm],差异有统计学意义(P＜0.05);四组颈动脉斑块总检出率比较差异有统计学意义(P＜0.01),两两比较,第4组颈动脉斑块总检出率最高[93.3％(28/30)],其次为第3组[79.3％(23/29)]和第2组[61.3％(19/31)],差异有统计学意义(P＜0.05).四组颈动脉斑块分型比较差异有统计学意义(x2=51.10,P＜ 0.01),HbA1c与颈动脉斑块分型之间存在一定的相关性(r=0.56,P＜ 0.01).结论 2型糖尿病患者HbA1c水平和颈动脉内皮细胞功能与斑块之间存在较强的联系.
目的 研究糖尿病患者不同糖化血紅蛋白(HbA1c)水平對頸動脈內皮細胞功能的影響.方法 選取2型糖尿病患者120例,根據HbA1c水平分組,6％≤HbA1c＜7％為第1組(30例),7％≤HbA1c＜8％為第2組(31例),8％≤HbA1c＜9％為第3組(29例),HbA1c≥9％為第4組(30例).分彆進行血管內皮功能指標的檢測以及頸動脈綵色多普勒超聲檢查併記錄.結果 四組血管內皮功能指標內皮素1(ET-1)與一氧化氮(NO)比較差異有統計學意義(P＜0.01),兩兩比較,第4組ET-1與NO最高[(89.3±19.2)ng/L、(59.5±9.3)μmol/L],其次為第3組[(85.9±16.4)ng/L、(56.4±8.9)μmol/L]和第2組[(83.4±17.3) ng/L、(52.3±8.3)μmol/L],差異有統計學意義(P＜0.05).四組頸動脈內膜-中層厚度(IMT)比較差異有統計學意義(P＜0.01),兩兩比較,第4組頸動脈IMT最大[(2.90±0.62) mm],其次為第3組[(2.40±0.73) mm]和第2組[(1.90±0.42) mm],差異有統計學意義(P＜0.05);四組頸動脈斑塊總檢齣率比較差異有統計學意義(P＜0.01),兩兩比較,第4組頸動脈斑塊總檢齣率最高[93.3％(28/30)],其次為第3組[79.3％(23/29)]和第2組[61.3％(19/31)],差異有統計學意義(P＜0.05).四組頸動脈斑塊分型比較差異有統計學意義(x2=51.10,P＜ 0.01),HbA1c與頸動脈斑塊分型之間存在一定的相關性(r=0.56,P＜ 0.01).結論 2型糖尿病患者HbA1c水平和頸動脈內皮細胞功能與斑塊之間存在較彊的聯繫.
목적 연구당뇨병환자불동당화혈홍단백(HbA1c)수평대경동맥내피세포공능적영향.방법 선취2형당뇨병환자120례,근거HbA1c수평분조,6％≤HbA1c＜7％위제1조(30례),7％≤HbA1c＜8％위제2조(31례),8％≤HbA1c＜9％위제3조(29례),HbA1c≥9％위제4조(30례).분별진행혈관내피공능지표적검측이급경동맥채색다보륵초성검사병기록.결과 사조혈관내피공능지표내피소1(ET-1)여일양화담(NO)비교차이유통계학의의(P＜0.01),량량비교,제4조ET-1여NO최고[(89.3±19.2)ng/L、(59.5±9.3)μmol/L],기차위제3조[(85.9±16.4)ng/L、(56.4±8.9)μmol/L]화제2조[(83.4±17.3) ng/L、(52.3±8.3)μmol/L],차이유통계학의의(P＜0.05).사조경동맥내막-중층후도(IMT)비교차이유통계학의의(P＜0.01),량량비교,제4조경동맥IMT최대[(2.90±0.62) mm],기차위제3조[(2.40±0.73) mm]화제2조[(1.90±0.42) mm],차이유통계학의의(P＜0.05);사조경동맥반괴총검출솔비교차이유통계학의의(P＜0.01),량량비교,제4조경동맥반괴총검출솔최고[93.3％(28/30)],기차위제3조[79.3％(23/29)]화제2조[61.3％(19/31)],차이유통계학의의(P＜0.05).사조경동맥반괴분형비교차이유통계학의의(x2=51.10,P＜ 0.01),HbA1c여경동맥반괴분형지간존재일정적상관성(r=0.56,P＜ 0.01).결론 2형당뇨병환자HbA1c수평화경동맥내피세포공능여반괴지간존재교강적련계.
Objective To study the effect of different grading glycosylated hemoglobin(HbA1c) on carotid artery endothelial cells in diabetic patients.Methods A total of 120 patients with type 2 diabetes mellitus patients were divided into 4 groups according to the different levels of HbA1c:6％ ≤HbA1c ＜ 7％ as group 1 (30 cases),7％ ≤HbA1c ＜ 8％ as group 2(31 cases),8％ ≤HbA1c ＜ 9％ as group 3(29 cases) and HbA1c ≥ 9％ as group 4 (30 cases).The indicators of endothelial function and carotid ultrasonography were detected and recorded.Results There was significant difference in endothelin-1 (ET-1) and nitric oxide (NO) among 4 groups (P ＜ 0.01).When compared between 2 groups,ET-1 and NO in group 4 was the highest [(89.3 ± 19.2) ng/L,(59.5 ± 9.3) μ mol/L],next was group 3 [(85.9 ± 16.4) ng/L,(56.4 ± 8.9)μ mol/L] and group 2[(83.4 ± 17.3) ng/L,(52.3 ± 8.3) μ mol/L],and there was significant difference (P ＜0.05).There was significant difference in carotid intima-mild thickness (IMT) among 4 groups (P ＜ 0.01).When compared between two groups,IMT in group 4 was the biggest [(2.90 ± 0.62) mm],next was group 3 [(2.40 ± 0.73)mm] and group 2[(1.90 ± 0.42) mm],and there was significant difference(P ＜ 0.05).There was significant difference in the incidence of carotid plaque among 4 groups (P ＜ 0.01).When compared between 2 groups,the incidence of carotid plaque in group 4 was the highest [93.3％(28/30)],next was group 3 [79.3％(23/29)]and group 2 [61.3％ (19/31)],and there was significant difference(P ＜ 0.05).There was significant difference in the type of carotid plaque among 4 groups (2 =51.10,P ＜ 0.01).HbA1c was correlated with the type of carotid plaque (r =0.56,P ＜0.01).Conclusion For patients with type 2 diabetes,there is a strong link between plaque,HbA1c level and carotid artery endothelial cells.
