CAJ | 학술논문

目的探讨葡萄糖调节蛋白(Grp)78在卵巢癌组织中的表达及临床意义.方法采用免疫组织化学法检测60例卵巢癌组织、15例卵巢交界性肿瘤组织、10例正常卵巢组织、10例卵巢囊肿组织Grp78阳性表达情况,分析其表达与卵巢癌临床特征的关系.结果卵巢交界性肿瘤和卵巢癌组织中Grp78阳性表达率明显高于正常卵巢和卵巢囊肿组织[7/15和68.3％(41/60)比1/10和1/10],差异有统计学意义(P＜0.05).Grp78表达与卵巢癌临床分期和淋巴结转移呈正相关(P＜0.05),与分化程度呈负相关(P＜0.05),与年龄及腹水无相关性(P＞0.05).结论卵巢癌组织中Grp78表达呈增高趋势;Grp78的高表达可能与卵巢癌的发生、发展及预后有重要联系.Grp78表达可作为判定卵巢癌发生及淋巴转移能力的一项有效客观指标.
목적 탐토포도당조절단백(Grp)78재란소암조직중적표체급림상의의.방법 채용면역조직화학법검측60례란소암조직、15례란소교계성종류조직、10례정상란소조직、10례란소낭종조직Grp78양성표체정황,분석기표체여란소암림상특정적관계.결과 란소교계성종류화란소암조직중Grp78양성표체솔명현고우정상란소화란소낭종조직[7/15화68.3％(41/60)비1/10화1/10],차이유통계학의의(P＜0.05).Grp78표체여란소암림상분기화림파결전이정정상관(P＜0.05),여분화정도정부상관(P＜0.05),여년령급복수무상관성(P＞0.05).결론 란소암조직중Grp78표체정증고추세;Grp78적고표체가능여란소암적발생、발전급예후유중요련계.Grp78표체가작위판정란소암발생급림파전이능력적일항유효객관지표.
Objective To explore the expression of glucose-regulated protein (Grp) 78 in ovarian cancer tissues and its clinical significance.Methods The expression of Grp78 in 60 cases of ovarian cancer tissue,15 cases of ovarian borderline tumor tissue,10 cases of normal ovarian tissue,10 cases of ovarian cyst tissue,was detected by immunohistochemistry,and analyzed the relationship between its expression and clinicopathological features of ovarian cancer.Results The expression of Grp78 in ovarian borderline tumor and ovarian cancer tissue was significantly higher than that in normal ovarian and ovarian cyst tissue[7/15 and 68.3％ (41/60) vs.1/10 and 1/10] (P ＜0.05).The expression of Grp78 was positively correlated with clinicopathological staging and lymphatic metastasis of ovarian cancer (P ＜ 0.05),negatively correlated with histological differentiation (P ＜ 0.05).No correlation with age and ascites (P ＞ 0.05).Conclusions The levels of Grp78 are elevated in ovarian cancer specimens; high expression of Grp78 maybe participate in the occurrence,development,and prognosis of ovarian cancer.Increased expression of Grp78 might be a useful marker for predicting the carcinogenesis and progression of ovarian cancer.