中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
16期
8-11
,共4页
李彩丽%刘岳%孙泽群%王斌
李綵麗%劉嶽%孫澤群%王斌
리채려%류악%손택군%왕빈
肺疾病,慢性阻塞性%胃肠道%胃电节律
肺疾病,慢性阻塞性%胃腸道%胃電節律
폐질병,만성조새성%위장도%위전절률
Pulmonary disease,chronic obstructive%Gastrointestinal tract%Gastric myoelectrical activity
目的 调查慢性阻塞性肺疾病(COPD)患者的胃肠道症状情况并探讨其可能的原因.方法 36例稳定期COPD患者依据肺功能进行分组,第1秒用力呼气容积(FEV1)实测值/预计值≥50％设为轻度组(21例),FEV1实测值/预计值＜50％设为重度组(15例),与19例健康志愿者(对照组)共同完成胃肠道症状评估量表(GSRS)评分,并接受胃电图描记及血浆血管活性肠肽(VIP)、肠脂肪酸结合蛋白(Ⅰ-FABP)检测.结果 重度组和轻度组GSRS评分均显著高于对照组[(17.73±4.64)、(14.29±5.44)分比(8.00±2.29)分],且重度组高于轻度组,差异均有统计学意义(P＜0.05).重度组和轻度组患者空腹及餐后正常慢波百分率、胃动过缓百分率均低于对照组,差异有统计学意义(P＜0.05).重度组患者VIP水平明显低于轻度组和对照组[(36.07±9.22)μg/L比(44.16±7.88)、(46.53±4.54) μg/L],Ⅰ-FABP水平明显高于轻度组和对照组[(35.80±11.69) μg/L比(27.40±9.53)、(23.58±8.18)μg/L],差异均有统计学意义(P＜0.05),但轻度组与对照组比较差异无统计学意义(P＞0.05).结论 COPD患者存在严重的胃肠道症状和胃电节律紊乱,重度COPD可伴有外周血VIP的下降和Ⅰ-FABP的上升.
目的 調查慢性阻塞性肺疾病(COPD)患者的胃腸道癥狀情況併探討其可能的原因.方法 36例穩定期COPD患者依據肺功能進行分組,第1秒用力呼氣容積(FEV1)實測值/預計值≥50％設為輕度組(21例),FEV1實測值/預計值＜50％設為重度組(15例),與19例健康誌願者(對照組)共同完成胃腸道癥狀評估量錶(GSRS)評分,併接受胃電圖描記及血漿血管活性腸肽(VIP)、腸脂肪痠結閤蛋白(Ⅰ-FABP)檢測.結果 重度組和輕度組GSRS評分均顯著高于對照組[(17.73±4.64)、(14.29±5.44)分比(8.00±2.29)分],且重度組高于輕度組,差異均有統計學意義(P＜0.05).重度組和輕度組患者空腹及餐後正常慢波百分率、胃動過緩百分率均低于對照組,差異有統計學意義(P＜0.05).重度組患者VIP水平明顯低于輕度組和對照組[(36.07±9.22)μg/L比(44.16±7.88)、(46.53±4.54) μg/L],Ⅰ-FABP水平明顯高于輕度組和對照組[(35.80±11.69) μg/L比(27.40±9.53)、(23.58±8.18)μg/L],差異均有統計學意義(P＜0.05),但輕度組與對照組比較差異無統計學意義(P＞0.05).結論 COPD患者存在嚴重的胃腸道癥狀和胃電節律紊亂,重度COPD可伴有外週血VIP的下降和Ⅰ-FABP的上升.
목적 조사만성조새성폐질병(COPD)환자적위장도증상정황병탐토기가능적원인.방법 36례은정기COPD환자의거폐공능진행분조,제1초용력호기용적(FEV1)실측치/예계치≥50％설위경도조(21례),FEV1실측치/예계치＜50％설위중도조(15례),여19례건강지원자(대조조)공동완성위장도증상평고량표(GSRS)평분,병접수위전도묘기급혈장혈관활성장태(VIP)、장지방산결합단백(Ⅰ-FABP)검측.결과 중도조화경도조GSRS평분균현저고우대조조[(17.73±4.64)、(14.29±5.44)분비(8.00±2.29)분],차중도조고우경도조,차이균유통계학의의(P＜0.05).중도조화경도조환자공복급찬후정상만파백분솔、위동과완백분솔균저우대조조,차이유통계학의의(P＜0.05).중도조환자VIP수평명현저우경도조화대조조[(36.07±9.22)μg/L비(44.16±7.88)、(46.53±4.54) μg/L],Ⅰ-FABP수평명현고우경도조화대조조[(35.80±11.69) μg/L비(27.40±9.53)、(23.58±8.18)μg/L],차이균유통계학의의(P＜0.05),단경도조여대조조비교차이무통계학의의(P＞0.05).결론 COPD환자존재엄중적위장도증상화위전절률문란,중도COPD가반유외주혈VIP적하강화Ⅰ-FABP적상승.
Objective To investigate the gastrointestinal symptoms in patients with chronic obstructive pulmonary disease (COPD) and explore its possible reasons.Methods Thirty-six patients with stable COPD were divided into mild group [21 cases,forced expiratory volume in first second (FEV1) measured values/predictive values ≥50％] and severe group (15 cases,FEV1 measured values/predictive values ＜ 50％) according to the pulmonary function.Replacement of 19 healthy volunteers as control group.The patients and volunteers completed the Gastrointestinal Symptom Rating Scales (GSRS) scores and received electrogastrography,the plasma vasoactive intestinal peptide (VIP) and intestinal fatty acid binding protein (Ⅰ-FABP) were detected.Results The GSRS scores in severe group and mild group was higher than that in control group[(17.73 ± 4.64),(14.29 ± 5.44) scores vs.(8.00 ± 2.29) scores],and severe group was higher than that in mild group,there was significant difference (P ＜ 0.05).The percentage of normal slow waves of fasting and postprandial,the percentage of bradygastria in severe group and mild group were lower than those in control group,there were significant differences(P ＜ 0.05).The level of VIP in severe group was lower than that in mild group and control group [(36.07 ± 9.22) μ g/L vs.(44.16 ± 7.88),(46.53 ± 4.54) μ g/L],the level of I-FABP was higher than that in mild group and control group [(35.80 ± 11.69) μ g/L vs.(27.40 ±9.53),(23.58 ±8.18) μg/L],there was significant difference (P ＜0.05),but there was no significant difference between mild group and control group (P ＞ 0.05).Conclusion The patients with COPD are accompanied with serious gastrointestinal symptoms and gastric dysrhythmia,severe COPD can be associated with VIP decrease and Ⅰ-FABP rise in peripheral blood.
