CAJ | 학술논문

目的探讨老年脓毒症患者并发肝功能不全的危险因素.方法采用病例-对照研究方法入选384例老年脓毒症患者,其中住院期间发生肝功能不全91例(病例组),未发生肝功能不全293例(对照组),对各种可能导致肝功能不全的相关危险因素进行单因素和多因素Logistic回归分析.结果单因素分析结果显示,年龄、饮酒史、慢性基础病、动脉血乳酸、机械通气和急性生理学与慢性健康状况评分Ⅲ(APACHE-Ⅲ)是老年脓毒症患者并发肝功能不全的危险因素(P＜ 0.01或＜ 0.05);多因素Logistic回归分析结果显示,年龄、饮酒史、慢性基础病、动脉血乳酸、机械通气和APACHE-Ⅲ是老年脓毒症患者并发肝功能不全的高危因素(P＜ 0.01或＜0.05).结论年龄、饮酒史、慢性基础病、动脉血乳酸、机械通气和APACHE-Ⅲ是老年脓毒症患者并发肝功能不全的高危因素.
목적 탐토노년농독증환자병발간공능불전적위험인소.방법 채용병례-대조연구방법입선384례노년농독증환자,기중주원기간발생간공능불전91례(병례조),미발생간공능불전293례(대조조),대각충가능도치간공능불전적상관위험인소진행단인소화다인소Logistic회귀분석.결과 단인소분석결과현시,년령、음주사、만성기출병、동맥혈유산、궤계통기화급성생이학여만성건강상황평분Ⅲ(APACHE-Ⅲ)시노년농독증환자병발간공능불전적위험인소(P＜ 0.01혹＜ 0.05);다인소Logistic회귀분석결과현시,년령、음주사、만성기출병、동맥혈유산、궤계통기화APACHE-Ⅲ시노년농독증환자병발간공능불전적고위인소(P＜ 0.01혹＜0.05).결론 년령、음주사、만성기출병、동맥혈유산、궤계통기화APACHE-Ⅲ시노년농독증환자병발간공능불전적고위인소.
Objective To explore the risk factors of sepsis complicated with hepatic insufficiency in elder patients.Methods With retrospective case-control study method,according to whether or not complicated with hepatic insufficiency,a total of 384 elder sepsis patients were divided into case group (91 patients) and control group(293 patients),then single factor analysis and multiple factors Logistic regression methods were used to screen the risk factors.Results Single factor analysis identified 6 kinds of significant variables,including age(P =0.000),history of alcohol(P =0.006),chronic diseases(P =0.001),arterial blood lactate level (P =0.035),mechanical ventilation (P =0.009) and acute physiology and chronic health evaluation Ⅲ score (APACHE-Ⅲ) scores(P =0.004).Multiple factors Logistic regression analysis showed that age,history of alcohol,chronic diseases,arterial blood lactate level,mechanical ventilation,APACHE-Ⅲ scores were correlated with sepsis complicated hepatic insuffciency in elder patients (P ＜ 0.01 or ＜ 0.05).Conclusion The risk factors which closely relate to sepsis complicated with hepatic insufficiency in elder patients are age,history of alcohol,chronic diseases,arterial blood lactate level,mechanical ventilation,APACHE-Ⅲ scores.