中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
17期
50-52
,共3页
胃肿瘤%复发%围手术期%腹腔区域化疗
胃腫瘤%複髮%圍手術期%腹腔區域化療
위종류%복발%위수술기%복강구역화료
Stomach neoplasms%Recurrences%Perioperative period%Regional intraperitoneal chemotherapy
目的 研究围手术期腹腔区域化疗对晚期胃癌复发的影响,为胃癌治疗和改善预后提供指导.方法 86例晚期胃癌患者按患者意愿分为对照组(42例)和观察组(44例),两组手术前后均采用PCF方案进行辅助化疗,观察组联合使用术中腹腔区域化疗,对照组单纯外科手术治疗,方法与观察组一致.比较两组的治疗效果和复发情况.结果 对照组有效率为76.2％(32/42),明显低于观察组的93.2％(41/44),差异有统计学意义(P＜0.05).两组不良反应发生情况比较差异无统计学意义(P＞0.05).随访3 ～ 36个月,观察组6例复发,对照组14例复发.两组患者远期(＞24个月)复发率比较差异有统计学意义(P＜0.05).结论 围手术期联合腹腔区域化疗对于抑制胃癌的复发具有良好的防治作用.
目的 研究圍手術期腹腔區域化療對晚期胃癌複髮的影響,為胃癌治療和改善預後提供指導.方法 86例晚期胃癌患者按患者意願分為對照組(42例)和觀察組(44例),兩組手術前後均採用PCF方案進行輔助化療,觀察組聯閤使用術中腹腔區域化療,對照組單純外科手術治療,方法與觀察組一緻.比較兩組的治療效果和複髮情況.結果 對照組有效率為76.2％(32/42),明顯低于觀察組的93.2％(41/44),差異有統計學意義(P＜0.05).兩組不良反應髮生情況比較差異無統計學意義(P＞0.05).隨訪3 ～ 36箇月,觀察組6例複髮,對照組14例複髮.兩組患者遠期(＞24箇月)複髮率比較差異有統計學意義(P＜0.05).結論 圍手術期聯閤腹腔區域化療對于抑製胃癌的複髮具有良好的防治作用.
목적 연구위수술기복강구역화료대만기위암복발적영향,위위암치료화개선예후제공지도.방법 86례만기위암환자안환자의원분위대조조(42례)화관찰조(44례),량조수술전후균채용PCF방안진행보조화료,관찰조연합사용술중복강구역화료,대조조단순외과수술치료,방법여관찰조일치.비교량조적치료효과화복발정황.결과 대조조유효솔위76.2％(32/42),명현저우관찰조적93.2％(41/44),차이유통계학의의(P＜0.05).량조불량반응발생정황비교차이무통계학의의(P＞0.05).수방3 ～ 36개월,관찰조6례복발,대조조14례복발.량조환자원기(＞24개월)복발솔비교차이유통계학의의(P＜0.05).결론 위수술기연합복강구역화료대우억제위암적복발구유량호적방치작용.
Objective To investigate the effect of perioperative regional intra peritoneal chemotherapy on postoperative recurrence of advanced gastric cancer.Methods Eighty-six patients with advanced gastric cancer were divided into observation group (44 patients) and control group (42 patients) according to the aspiration of patients.All patients received 2-4 cycles of chemotherapy of PCF regimen before and after surgical treatment.Observation group was combined with perioperative regional intraperitoneal chemotherapy,and control group only received surgical treatment.The treatment effectiveness and the status of postoperative recurrence were compared between two groups.Results The response rate of control group and observation group were 76.2％ (34/42) and 93.2％ (41/44),respectively.There was significant difference (P ＜ 0.05).The adverse effect of the two groups were gastrointestinal adverse reaction and myelosuppression.There was no significant difference between two groups (P＞ 0.05).After followed up for 3-36 months,6 patients in observation group occurred recurrence,and 14 patients in control group occurred recurrence.The long-term recurrence rate (＞ 24 months) between two groups had significant difference (P ＜ 0.05).Conclusion Perioperative regional intraperitoneal chemotherapy has better effectiveness on inhibiting the postoperative recurrence of advanced gastric cancer.
