中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
17期
59-61
,共3页
癌,肝细胞%免疫组织化学%聚集素%P糖蛋白
癌,肝細胞%免疫組織化學%聚集素%P糖蛋白
암,간세포%면역조직화학%취집소%P당단백
Carcinoma,hepatocellular%Immunohistochemistry%Clusterin%P-glycoprotein
目的 探讨聚集素(CLU)在原发性肝细胞癌(HCC)中的表达及其与P-糖蛋白(P-gp)表达的相关性.方法 采用免疫组化法检测凋亡抑制基因CLU在HCC(41例)、肝硬化(10例)和正常肝脏(10例)组织中的表达及P-gp在HCC中的表达.结果 CLU在41例HCC组织中阳性表达率为82.93％(34/41),10例肝硬化和10例正常肝脏组织中表达阴性或弱阳性.在HCC组织中,CLU阳性表达与年龄、性别及有无合并肝硬化无相关性(P＞0.05),而与Edmondson分级明显相关(P＜0.05).P-gp在HCC组织中的阳性表达率为70.73％(29/41).在HCC组织中,CLU的表达与P-gp表达呈正相关(P＜0.05).结论 CLU在HCC中呈高表达,与临床耐药密切相关,有望成为HCC靶向治疗的一个新靶点.
目的 探討聚集素(CLU)在原髮性肝細胞癌(HCC)中的錶達及其與P-糖蛋白(P-gp)錶達的相關性.方法 採用免疫組化法檢測凋亡抑製基因CLU在HCC(41例)、肝硬化(10例)和正常肝髒(10例)組織中的錶達及P-gp在HCC中的錶達.結果 CLU在41例HCC組織中暘性錶達率為82.93％(34/41),10例肝硬化和10例正常肝髒組織中錶達陰性或弱暘性.在HCC組織中,CLU暘性錶達與年齡、性彆及有無閤併肝硬化無相關性(P＞0.05),而與Edmondson分級明顯相關(P＜0.05).P-gp在HCC組織中的暘性錶達率為70.73％(29/41).在HCC組織中,CLU的錶達與P-gp錶達呈正相關(P＜0.05).結論 CLU在HCC中呈高錶達,與臨床耐藥密切相關,有望成為HCC靶嚮治療的一箇新靶點.
목적 탐토취집소(CLU)재원발성간세포암(HCC)중적표체급기여P-당단백(P-gp)표체적상관성.방법 채용면역조화법검측조망억제기인CLU재HCC(41례)、간경화(10례)화정상간장(10례)조직중적표체급P-gp재HCC중적표체.결과 CLU재41례HCC조직중양성표체솔위82.93％(34/41),10례간경화화10례정상간장조직중표체음성혹약양성.재HCC조직중,CLU양성표체여년령、성별급유무합병간경화무상관성(P＞0.05),이여Edmondson분급명현상관(P＜0.05).P-gp재HCC조직중적양성표체솔위70.73％(29/41).재HCC조직중,CLU적표체여P-gp표체정정상관(P＜0.05).결론 CLU재HCC중정고표체,여림상내약밀절상관,유망성위HCC파향치료적일개신파점.
Objective To study the expression of clusterin (CLU) and P-glycoprotein (P-gp) in hepatic cell carcinoma (HCC) and its relationship.Methods The expression of CLU gene in the tissue of H CC (41 cases),cirrhosis(10 cases) and normal liver (10 cases) and the expression of P-gp in the tissue of HCC were detected by immunohistochemical method.Results The positive expression rate of CLU was 82.93％(34/41) in HCC,and negative or weak positive were detected in cirrhosis and normal liver tissue.The positive expression rate of CLU was significantly correlated with Edmondson's histological grade (P ＜ 0.05),but had no correlation with patients' age,sex and cirrhosis (P ＞ 0.05).The positive expression rate of P-gp in HCC was 70.73％(29/41).There was significant correlation between the expression of CLU and P-gp (P ＜ 0.05).Conclusions The over expression of CLU is significantly associated with clinical multidrug resistance in HCC.It should be a potential target for treatment of HCC.
