中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
19期
24-27
,共4页
螺杆菌,幽门%胃炎%序贯疗法%三联疗法
螺桿菌,幽門%胃炎%序貫療法%三聯療法
라간균,유문%위염%서관요법%삼련요법
Helicobacter pylori%Gastritis%Sequential therapy%Trigeming therapy
目的 探讨不同方法根除幽门螺杆菌(Hp)对慢性胃炎患者预后的影响.方法 120例经胃镜及病理确诊为慢性胃炎患者,根据Hp感染情况分为序贯治疗组(36例)、三联治疗组(34例)、Hp阳性不根除组(30例)和Hp阴性组(20例).治疗前和治疗后对患者进行随访,行慢性胃炎症状评分,总疗程结束后复查胃镜及快速尿素酶试验,同时取组织做Hp检测,最后对患者的情况进行统计学分析.结果 序贯治疗组的Hp根除率为94.44％(34/36),三联治疗组的Hp根除率为73.53％(25/34),两组Hp根除率比较差异有统计学意义(x2=5.775,P=0.016).四组症状评分和内镜评分治疗后较治疗前均有明显改善,差异有统计学意义(P＜ 0.05),序贯治疗组和三联治疗组相比,缓解效果更好,差异有统计学意义(P＜0.05).序贯治疗组、三联治疗组和Hp阴性组治疗后症状评分和内镜评分均比Hp阳性不根除组改善明显[(0.84 ±0.60)、(1.34±0.59)、(1.49±0.62)分比(2.98±0.54)分,(0.47±0.37)、(0.83±0.35)、(0.96±0.75)分比(1.22±0.40)分],差异有统计学意义(P＜0.05).结论 序贯疗法在Hp根除率上优于三联疗法;两种方案均可显著改善慢性胃炎患者的症状及内镜下胃炎的严重程度,但序贯治疗患者慢性胃炎症状缓解更快.
目的 探討不同方法根除幽門螺桿菌(Hp)對慢性胃炎患者預後的影響.方法 120例經胃鏡及病理確診為慢性胃炎患者,根據Hp感染情況分為序貫治療組(36例)、三聯治療組(34例)、Hp暘性不根除組(30例)和Hp陰性組(20例).治療前和治療後對患者進行隨訪,行慢性胃炎癥狀評分,總療程結束後複查胃鏡及快速尿素酶試驗,同時取組織做Hp檢測,最後對患者的情況進行統計學分析.結果 序貫治療組的Hp根除率為94.44％(34/36),三聯治療組的Hp根除率為73.53％(25/34),兩組Hp根除率比較差異有統計學意義(x2=5.775,P=0.016).四組癥狀評分和內鏡評分治療後較治療前均有明顯改善,差異有統計學意義(P＜ 0.05),序貫治療組和三聯治療組相比,緩解效果更好,差異有統計學意義(P＜0.05).序貫治療組、三聯治療組和Hp陰性組治療後癥狀評分和內鏡評分均比Hp暘性不根除組改善明顯[(0.84 ±0.60)、(1.34±0.59)、(1.49±0.62)分比(2.98±0.54)分,(0.47±0.37)、(0.83±0.35)、(0.96±0.75)分比(1.22±0.40)分],差異有統計學意義(P＜0.05).結論 序貫療法在Hp根除率上優于三聯療法;兩種方案均可顯著改善慢性胃炎患者的癥狀及內鏡下胃炎的嚴重程度,但序貫治療患者慢性胃炎癥狀緩解更快.
목적 탐토불동방법근제유문라간균(Hp)대만성위염환자예후적영향.방법 120례경위경급병리학진위만성위염환자,근거Hp감염정황분위서관치료조(36례)、삼련치료조(34례)、Hp양성불근제조(30례)화Hp음성조(20례).치료전화치료후대환자진행수방,행만성위염증상평분,총료정결속후복사위경급쾌속뇨소매시험,동시취조직주Hp검측,최후대환자적정황진행통계학분석.결과 서관치료조적Hp근제솔위94.44％(34/36),삼련치료조적Hp근제솔위73.53％(25/34),량조Hp근제솔비교차이유통계학의의(x2=5.775,P=0.016).사조증상평분화내경평분치료후교치료전균유명현개선,차이유통계학의의(P＜ 0.05),서관치료조화삼련치료조상비,완해효과경호,차이유통계학의의(P＜0.05).서관치료조、삼련치료조화Hp음성조치료후증상평분화내경평분균비Hp양성불근제조개선명현[(0.84 ±0.60)、(1.34±0.59)、(1.49±0.62)분비(2.98±0.54)분,(0.47±0.37)、(0.83±0.35)、(0.96±0.75)분비(1.22±0.40)분],차이유통계학의의(P＜0.05).결론 서관요법재Hp근제솔상우우삼련요법;량충방안균가현저개선만성위염환자적증상급내경하위염적엄중정도,단서관치료환자만성위염증상완해경쾌.
Objective To compare the prognosis effect of different Helicobacter pylori (Hp)eradication methods in patients with chronic gastritis.Methods One hundred and twenty patients with chronic gastritis diagnosed by gastroscopy and pathology examination were divided into sequential therapy group (36 cases),triple-combined therapy group (34 cases),Hp positive without eradication group (30cases) and Hp negative group (20 cases) according to the Hp infection status.All patients were followed up by gastroscopy,biopsy and rapid urease test before and after therapy.Results The Hp eradication rate in sequential therapy group was 94.44％ (34/36),in triple-combined therapy group was 73.53％ (25/34),and there was statistical difference (x2 =5.775,P =0.016).The symptoms scores and gastroscopy scores after therapy in the four groups were significantly lower than those before therapy,and there were statistical differences (P ＜ 0.05).The symptoms scores and gastroscopy scores after therapy in sequential therapy group were significantly lower than those in triple-combined therapy group,and there were statistical differences (P ＜0.05).The symptoms scores and gastroscopy scores after therapy in sequential therapy group,triple-combined therapy group and Hp negative group were significantly lower than those in Hp positive without eradication group [(0.84 ± 0.60),(1.34 ± 0.59),(1.49 ± 0.62) scores vs.(2.98 ± 0.54) scores,(0.47 ± 0.37),(0.83 ± 0.35),(0.96 ± 0.75) scores vs.(1.22 ± 0.40) scores],and there were statistical differences (P ＜ 0.05).Conclusions The Hp eradication rate of sequential therapy is higher than that of triple-combined therapy.The two therapy methods can both improve the symptoms score and gastroscopy score,but the symptoms after sequential therapy are relieved faster compared with triple-combined therapy.
