CAJ | 학술논문

1例81岁女性患者因肺部真菌感染静脉滴注氟康唑200 mg,1次/d.输注10 min后患者心电图显示频发室性早搏,随即静脉注射利多卡因及静脉滴注氯化钾,10 min后心电图显示尖端扭转型室性心动过速,继而出现心室颤动.立即给予胸外按压和电除颤、并静脉给予利多卡因、硫酸镁及门冬氨酸钾镁等治疗.次日输注氟康唑注射液5 min后再次发生尖端扭转型室性心动过速和心室颤动.停用氟康唑注射液,改用伊曲康唑注射液抗真菌治疗.此后未再出现尖端扭转型室性心动过速和心室颤动.
1례81세녀성환자인폐부진균감염정맥적주불강서200 mg,1차/d.수주10 min후환자심전도현시빈발실성조박,수즉정맥주사리다잡인급정맥적주록화갑,10 min후심전도현시첨단뉴전형실성심동과속,계이출현심실전동.립즉급여흉외안압화전제전、병정맥급여리다잡인、류산미급문동안산갑미등치료.차일수주불강서주사액5 min후재차발생첨단뉴전형실성심동과속화심실전동.정용불강서주사액,개용이곡강서주사액항진균치료.차후미재출현첨단뉴전형실성심동과속화심실전동.
An 81-year-old woman with pulmonary fungal infection received an Ⅳ infusion of fluconazole 200 mg once daily.Ten minutes after infusion started,the patient's electrocardiogram showed frequent ventricular premature beats,and then an Ⅳ push of lidocaine and an Ⅳ infusion of potassium chloride were given immediately.Ten minutes later,the patient's electrocardiogram showed torsades de pointes and ventricular fibrillation.She was immediately treated with chest compression and defibrillation,followed by Ⅳ lidocaine,Ⅳ magnesium sulfate and Ⅳ potassium magnesium aspirate.The next day,torsades de pointes and ventricular fibrillation occurred again 5 minutes after an Ⅳ infusion of fluconazole.Fluconazole was withdrawn immediately and her therapy was changed to itraconazole injection for antifungal therapy.After this change,her torsades de pointes and ventricular fibrillation did not recur.