CAJ | 학술논문

2例患者因慢性乙型肝炎(乙肝)长期接受阿德福韦酯(ADV) 10 mg/d治疗出现肢体疼痛,全身乏力.例1为58岁男性患者,例2为55岁女性患者,实验室检查血磷分别为0.71和0.58mmol/L,24 h尿磷分别为6.82和4.57 mmol/24 h；关节部位X线检查均显示骨质疏松；骨扫描检查示放射性物质摄取增高,诊断为低血磷性骨病.例1肌电图检查提示有周围神经受累,考虑低血磷性骨病并发周围神经病.继续服用阿德福韦酯情况下,给予补充磷酸盐治疗及食用富含磷酸盐食物,患者症状均有改善.
2례환자인만성을형간염(을간)장기접수아덕복위지(ADV) 10 mg/d치료출현지체동통,전신핍력.례1위58세남성환자,례2위55세녀성환자,실험실검사혈린분별위0.71화0.58mmol/L,24 h뇨린분별위6.82화4.57 mmol/24 h；관절부위X선검사균현시골질소송；골소묘검사시방사성물질섭취증고,진단위저혈린성골병.례1기전도검사제시유주위신경수루,고필저혈린성골병병발주위신경병.계속복용아덕복위지정황하,급여보충린산염치료급식용부함린산염식물,환자증상균유개선.
Two patients with chronic hepatitis B developed limb pain and asthenia after receiving adefovir dipivoxil (ADV) 10 mg/d.Patient 1 were male aged 58,patient 2 were female aged 55.Laboratory tests revealed that serum phosphorus levels in patients 1 and 2 were 0.71 and 0.58 mmol/L,respectively;24-hour urinary phosphorus levels in patients 1 and 2 were 6.82 and 4.57 mmo]/24 h,respectively.Joint X-ray showed osteoporosis; a bone scan revealed increased radiotracer uptake.The 2 patients were diagnosed with hypophosphatemic bone disease.Electromyography showed peripheral nerve damage in patient 1 and he was considcred to have hypophosphatemic bone disease complicated with peripheral neuropathy.Adefovir dipivoxil was continued,supplementary phosphate and phosphorus-rich foods were given,their symptoms improved.