CAJ | 학술논문

1例62岁男性患者因大疱性类天疱疮入院,给予泼尼松(15 mg,3次/d)、氯雷他定(10 mg,1次/d)、头孢拉定(0.5g,3次/d)口服及对症支持治疗.3d后患者偶有情绪不稳,但未予治疗.7d后因发疹未完全控制,将泼尼松改为60 mg/d.8d后患者出现焦虑不安、烦躁、易怒、被害妄想、言行失常、记忆力减退,偶不能辨识处所.遂将泼尼松减量至45 mg/d,停用氯雷他定,改为赛庚啶2 mg,3次/d口服,余治疗同前.1周后患者精神症状逐渐缓解出院.此后泼尼松逐步减量至出院45 d后停用.随访3个月,无类似精神症状再发.
1례62세남성환자인대포성류천포창입원,급여발니송(15 mg,3차/d)、록뢰타정(10 mg,1차/d)、두포랍정(0.5g,3차/d)구복급대증지지치료.3d후환자우유정서불은,단미여치료.7d후인발진미완전공제,장발니송개위60 mg/d.8d후환자출현초필불안、번조、역노、피해망상、언행실상、기억력감퇴,우불능변식처소.수장발니송감량지45 mg/d,정용록뢰타정,개위새경정2 mg,3차/d구복,여치료동전.1주후환자정신증상축점완해출원.차후발니송축보감량지출원45 d후정용.수방3개월,무유사정신증상재발.
A 62-year-old male patient was hospitalized with bullous pemphigoid.He received prednisone 15 mg thrice daily,loratadine 10 mg once daily,and cefradine 0.5 g thrice daily by mouth as well as symptomatic and supportive therapy.Three days later,occasional agitation appeared in the patient.However,he did not receive any treatment.Seven days later,the dose of prednisone was increased to 60 mg/d for poor control of rash.Eight days later,he experienced anxiety,dysphoria,agitation,persecutory delusion,abnormal behavior,memory loss,and occasional failure to recognise location.The dose of prednisone was then decreased to 45 mg/d.Loratadine was discontinued.He was switched to oral cyproheptadine 2 mg thrice daily,and other therapy was the same as before.One week later,the patient's psychiatric symptoms gradually relieved and he was discharged.The dose of prednisone was gradually reduced and then stopped 45 days after discharge.The patient had no recurrence of similar psychiatric symptoms at a 3-month follow-up.