药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2013年
1期
54-55
,共2页
肝炎,慢性,药物性%灵芝益寿胶囊
肝炎,慢性,藥物性%靈芝益壽膠囊
간염,만성,약물성%령지익수효낭
Hepatitis,chronic,drug-induced%Lingzhiyishou capsules
1例53岁女性患者,为滋补强身自行服用灵芝益寿胶囊4粒,3次/d.2个月后出现尿色深黄.约4个月后出现皮肤、巩膜黄染,上腹部不适,伴有恶心、乏力、倦怠.实验室检查:丙氨酸转氨酶(ALT)1114 U/L,天冬氨酸转氨酶(AST)611 U/L,γ-L-谷氨酰转移酶(γ-GT)235 U/L,碱性磷酸酶(ALP) 158 U/L,总胆红素(TBil) 104.5 μmol/L,直接胆红素(DBil) 63.2 μmol/L,间接胆红素(IBil)41.3 μmol/L,总胆汁酸(TBA) 165.3 μmol/L.诊断:药物性肝损害.停用灵芝益寿胶囊,给予还原型谷胱甘肽、异甘草酸镁及丁二磺酸腺苷蛋氨酸治疗.2周后复查肝功能:ALT 69 U/L,AST 35 U/L,γ-GT 100 U/L,ALP 137 U/L,TBil 30.1 μmol/L,DBil 14.4 μmol/L,IBil 15.7 μmol/L,TBA 70.2 μmol/L.
1例53歲女性患者,為滋補彊身自行服用靈芝益壽膠囊4粒,3次/d.2箇月後齣現尿色深黃.約4箇月後齣現皮膚、鞏膜黃染,上腹部不適,伴有噁心、乏力、倦怠.實驗室檢查:丙氨痠轉氨酶(ALT)1114 U/L,天鼕氨痠轉氨酶(AST)611 U/L,γ-L-穀氨酰轉移酶(γ-GT)235 U/L,堿性燐痠酶(ALP) 158 U/L,總膽紅素(TBil) 104.5 μmol/L,直接膽紅素(DBil) 63.2 μmol/L,間接膽紅素(IBil)41.3 μmol/L,總膽汁痠(TBA) 165.3 μmol/L.診斷:藥物性肝損害.停用靈芝益壽膠囊,給予還原型穀胱甘肽、異甘草痠鎂及丁二磺痠腺苷蛋氨痠治療.2週後複查肝功能:ALT 69 U/L,AST 35 U/L,γ-GT 100 U/L,ALP 137 U/L,TBil 30.1 μmol/L,DBil 14.4 μmol/L,IBil 15.7 μmol/L,TBA 70.2 μmol/L.
1례53세녀성환자,위자보강신자행복용령지익수효낭4립,3차/d.2개월후출현뇨색심황.약4개월후출현피부、공막황염,상복부불괄,반유악심、핍력、권태.실험실검사:병안산전안매(ALT)1114 U/L,천동안산전안매(AST)611 U/L,γ-L-곡안선전이매(γ-GT)235 U/L,감성린산매(ALP) 158 U/L,총담홍소(TBil) 104.5 μmol/L,직접담홍소(DBil) 63.2 μmol/L,간접담홍소(IBil)41.3 μmol/L,총담즙산(TBA) 165.3 μmol/L.진단:약물성간손해.정용령지익수효낭,급여환원형곡광감태、이감초산미급정이광산선감단안산치료.2주후복사간공능:ALT 69 U/L,AST 35 U/L,γ-GT 100 U/L,ALP 137 U/L,TBil 30.1 μmol/L,DBil 14.4 μmol/L,IBil 15.7 μmol/L,TBA 70.2 μmol/L.
A 53-year-old woman self-medicated with 4 Lingzhiyishou capsules thrice daily to improve physical strength and vitality.Two months later,the patient developed dark urine.About four months later,she presented with jaundiced skin and sclera,upper abdominal discomfort,accompanied by nausea,fatigue,and lassitude.Laboratory tests revealed the following levels:alanine aminotransferase (ALT) 1114 U/L,aspartate aminotransferase (AST) 611 U/L,γ-glutamyl transferase (γ-GT) 235 U/L,alkaline phosphatase (ALP) 158 U/L,total bilirubin (TBil) 104.5 μmol/L,direct bilirubin (DBil) 63.2 μmol/L,indirect bilirubin (IBil) 41.3 μmol/L,total bile acid (TBA) 165.3 μmol/L.She was diagnosed with drug-induced liver injury.Lingzhiyishou capsules were stopped and she was given reduced glutathione,magnesium isoglycyrrhizinate,and ademetionine 1,4-butanedisulfonate.Two week later,repeat liver function tests showed the following levels:ALT 69 U/L,AST 35 U/L,γ-GT 100 U/L,ALP 137 U/L,TBil 30.1 μmol/L,DBil 14.4 μmol/L,IBil 15.7 μmol/L,TBA 70.2 μmol/L.
