药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2013年
2期
96-97
,共2页
甲巯咪唑%胆汁淤积,肝内
甲巰咪唑%膽汁淤積,肝內
갑구미서%담즙어적,간내
Thiamazole%Choiestasis,intrahepatic
1例51岁女性患者因甲状腺功能亢进症服用甲巯咪唑5 mg,1次/d,10 d后出现皮肤瘙痒、恶心、呕吐、大便呈灰白色,第15天停用甲巯咪唑.实验室检查示丙氨酸转氨酶(ALT) 184 U/L,天冬氨酸转氨酶(AST) 115 U/L,总胆红素(TBil) 41.6 μmol/L,直接胆红素(DBil) 28.6 μmol/L,碱性磷酸酶(ALP) 342 U/L.考虑为药物所致胆汁淤积型肝损伤.遂静脉滴注脱氧核苷酸钠注射液150 mg,1次/d和注射用复合辅酶400 U,2次/d.保肝治疗第7天ALT 150 U/L,AST 67 U/L,TBil28.7 μmol/L,DBIL19.1 μmol/L;第13天ALT 93 U/L,AST57 U/L;第28天ALT 62 U/L,AST45 U/L,TBil 11.1μmol/L,DBil 5.8 μmol/L.
1例51歲女性患者因甲狀腺功能亢進癥服用甲巰咪唑5 mg,1次/d,10 d後齣現皮膚瘙癢、噁心、嘔吐、大便呈灰白色,第15天停用甲巰咪唑.實驗室檢查示丙氨痠轉氨酶(ALT) 184 U/L,天鼕氨痠轉氨酶(AST) 115 U/L,總膽紅素(TBil) 41.6 μmol/L,直接膽紅素(DBil) 28.6 μmol/L,堿性燐痠酶(ALP) 342 U/L.攷慮為藥物所緻膽汁淤積型肝損傷.遂靜脈滴註脫氧覈苷痠鈉註射液150 mg,1次/d和註射用複閤輔酶400 U,2次/d.保肝治療第7天ALT 150 U/L,AST 67 U/L,TBil28.7 μmol/L,DBIL19.1 μmol/L;第13天ALT 93 U/L,AST57 U/L;第28天ALT 62 U/L,AST45 U/L,TBil 11.1μmol/L,DBil 5.8 μmol/L.
1례51세녀성환자인갑상선공능항진증복용갑구미서5 mg,1차/d,10 d후출현피부소양、악심、구토、대편정회백색,제15천정용갑구미서.실험실검사시병안산전안매(ALT) 184 U/L,천동안산전안매(AST) 115 U/L,총담홍소(TBil) 41.6 μmol/L,직접담홍소(DBil) 28.6 μmol/L,감성린산매(ALP) 342 U/L.고필위약물소치담즙어적형간손상.수정맥적주탈양핵감산납주사액150 mg,1차/d화주사용복합보매400 U,2차/d.보간치료제7천ALT 150 U/L,AST 67 U/L,TBil28.7 μmol/L,DBIL19.1 μmol/L;제13천ALT 93 U/L,AST57 U/L;제28천ALT 62 U/L,AST45 U/L,TBil 11.1μmol/L,DBil 5.8 μmol/L.
A 51-year-old woman with hyperthyroidism was given thiamazole 5 mg once daily.Ten days later,the patient presented itchiness,nausea,vomiting,and gray excrements.On day 15,the thiamazole was withdrawn.Laboratory examination revealed the following levels:alanine aminotransferase (ALT) 184 U/L,aspartate aminotransferase(AST) 115 U/L,total bilirubin(TBil) 41.6 μmol/L,and direct bilirubin (DBil) 28.6 μmol/L.The patient was considered as cholestatic liver injury.She was given an Ⅳ infusion of sodium deoxyribonucleotide injection 150 mg once daily and coenzyme complex for injection 400 U twice daily.On day 7 of liver-protective treatment,laboratory examination showed the following levels:ALT 150 U/L,AST 67 U/L,TBil 28.7 μmol/L,and DBil 19.1 μmol/L.On day 13,the levels of ALT and AST were 93 U/L,and 57 U/L,respectively.On day 28,the levels of ALT,AST,TBil and DBil were 62 U/L,45 U/L,11.1 μmol/L,and 5.8 μmol/L,respectively.
