CAJ | 학술논문

1例80岁女性患者因股骨髁间骨折切开复位内固定术后切口引流液培养检出阴沟肠杆菌,给予亚胺培南西司他丁钠0.5g,1次/8 h静脉滴注.第3天,嗜酸粒细胞计数由用药前的230×106/L升至520×106/L.第9天,嗜酸粒细胞计数为770×106/L.第11天,因切口引流液培养检出凝固酶阴性葡萄球菌,加用盐酸万古霉素1g,1次/12 h静脉滴注.第18天,嗜酸粒细胞计数升至1810×106/L,停用亚胺培南西司他丁钠.第21天,患者出现双下肢皮疹伴瘙痒,给予抗过敏治疗.第26天,患者病情好转,嗜酸粒细胞计数仍高达2990×106/L,停用盐酸万古霉素.其后皮疹逐渐消退.第48天,嗜酸粒细胞计数降至20×106/L.
1례80세녀성환자인고골과간골절절개복위내고정술후절구인류액배양검출음구장간균,급여아알배남서사타정납0.5g,1차/8 h정맥적주.제3천,기산립세포계수유용약전적230×106/L승지520×106/L.제9천,기산립세포계수위770×106/L.제11천,인절구인류액배양검출응고매음성포도구균,가용염산만고매소1g,1차/12 h정맥적주.제18천,기산립세포계수승지1810×106/L,정용아알배남서사타정납.제21천,환자출현쌍하지피진반소양,급여항과민치료.제26천,환자병정호전,기산립세포계수잉고체2990×106/L,정용염산만고매소.기후피진축점소퇴.제48천,기산립세포계수강지20×106/L.
An 80-year-old female patient was given an Ⅳ infusion of imipenem and cilastatin sodium 0.5 g every 8 hours for Enterobacter cloacae detected in fluid drainage of incision after intercondylar fracture of femur open reduction and internal fixation.On day 3,the eosinophil count was increased from 230 × 106/L before using this medicine to 520 × 106/L.On day 9,her eosinophil count was 770 × 106/L.On day 11,an Ⅳ infusion of vancomycin hydrochloride 1 g every 12 hours was prescribed for coagulase negative Staphylococcus detected in fluid drainage of incision.On day 18,the eosinophil count was 1810 × 106/L.Imipenem and cilastatin sodium was stopped.On day 21,the patient developed skin rash with pruritus on both lower extremities.She was given anti-allergic therapy.On day 26,her conditions improved,but the eosinophil count was still 2990 × 106/L.So vancomycin hydrochloride was stopped.The patient's rash gradually subsided.On day 48,the eosinophil count decreased to 20 × 106/L.