药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2013年
2期
108-109
,共2页
桂哌齐特%药物性肝损伤
桂哌齊特%藥物性肝損傷
계고제특%약물성간손상
Cinepazide%Drug induced liver injuty
1例73岁男性因急性脑梗死合并癫痫、高血压、支气管炎、冠状动脉粥样硬化性心脏病、心房颤动入院,先后给予甘露醇、甘油果糖,缬沙坦、富马酸比索洛尔、马来酸桂哌齐特、奥扎格雷钠、哌拉西林钠他唑巴坦钠、头孢他啶、依替米星、阿托伐他汀钙.用药前丙氨酸转氨酶(ALT)18 U/L,天冬氨酸转氨酶(AST)25 U/L.第13天,ALT 243 U/L,AST 111 U/L.停用马来酸桂哌齐特并给予葡醛内酯、谷胱甘肽.停用马来酸桂哌齐特第7天,ALT36 U/L,AST 27 U/L.
1例73歲男性因急性腦梗死閤併癲癇、高血壓、支氣管炎、冠狀動脈粥樣硬化性心髒病、心房顫動入院,先後給予甘露醇、甘油果糖,纈沙坦、富馬痠比索洛爾、馬來痠桂哌齊特、奧扎格雷鈉、哌拉西林鈉他唑巴坦鈉、頭孢他啶、依替米星、阿託伐他汀鈣.用藥前丙氨痠轉氨酶(ALT)18 U/L,天鼕氨痠轉氨酶(AST)25 U/L.第13天,ALT 243 U/L,AST 111 U/L.停用馬來痠桂哌齊特併給予葡醛內酯、穀胱甘肽.停用馬來痠桂哌齊特第7天,ALT36 U/L,AST 27 U/L.
1례73세남성인급성뇌경사합병전간、고혈압、지기관염、관상동맥죽양경화성심장병、심방전동입원,선후급여감로순、감유과당,힐사탄、부마산비색락이、마래산계고제특、오찰격뢰납、고랍서림납타서파탄납、두포타정、의체미성、아탁벌타정개.용약전병안산전안매(ALT)18 U/L,천동안산전안매(AST)25 U/L.제13천,ALT 243 U/L,AST 111 U/L.정용마래산계고제특병급여포철내지、곡광감태.정용마래산계고제특제7천,ALT36 U/L,AST 27 U/L.
A 73-year-old man was hospitalized for acute cerebral infarction accompanied by epilepsy,hypertension,bronchitis,coronary atherosclerotic heart disease,and atrial fibrillation.He received mannitol,glycerol and fructose,valsartan,bisoprolol fumarate,cinepazide maleate,ozagrel sodium,piperacillin sodium and tazobactam sodium,ceftazidime,etimicin,and atorvastatin calcium.Laboratory tests before treatment showed the following levels:alanine aminotransferase (ALT) 18 U/L,aspartate aminotransferase (AST) 25 U/L.On day 13,his ALT and AST levels increased to 243 U/L and 111 U/L.Cinepazide maleate was stopped.Glucurolactone and glutathione were given.On day 7 of cinepazide maleate withdrawal,his ALT and AST levels decreased to 36 U/L and 27 U/L.respectively.
